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1.
Nat Commun ; 15(1): 10, 2024 01 02.
Artículo en Inglés | MEDLINE | ID: mdl-38169465

RESUMEN

Tactile function is essential for human life as it enables us to recognize texture and respond to external stimuli, including potential threats with sharp objects that may result in punctures or lacerations. Severe skin damage caused by severe burns, skin cancer, chemical accidents, and industrial accidents damage the structure of the skin tissue as well as the nerve system, resulting in permanent tactile sensory dysfunction, which significantly impacts an individual's daily life. Here, we introduce a fully-implantable wireless powered tactile sensory system embedded artificial skin (WTSA), with stable operation, to restore permanently damaged tactile function and promote wound healing for regenerating severely damaged skin. The fabricated WTSA facilitates (i) replacement of severely damaged tactile sensory with broad biocompatibility, (ii) promoting of skin wound healing and regeneration through collagen and fibrin-based artificial skin (CFAS), and (iii) minimization of foreign body reaction via hydrogel coating on neural interface electrodes. Furthermore, the WTSA shows a stable operation as a sensory system as evidenced by the quantitative analysis of leg movement angle and electromyogram (EMG) signals in response to varying intensities of applied pressures.


Asunto(s)
Piel Artificial , Humanos , Biónica , Tacto/fisiología , Piel , Cicatrización de Heridas , Órganos de los Sentidos
2.
ACS Appl Mater Interfaces ; 5(5): 1806-10, 2013 Mar 13.
Artículo en Inglés | MEDLINE | ID: mdl-23379256

RESUMEN

A benzotrithiophene polymer with a new thermally cleavable ketal substituent is reported. It is shown how this functional group can be used to facilitate solvent processing and, subsequently, how it can be removed by a thermal annealing process to generate a structurally ordered and crystalline thin film with significantly improved field-effect transistor properties.

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