AI-driven robotic chemist for autonomous synthesis of organic molecules.

The automation of organic compound synthesis is pivotal for expediting the development of such compounds. In addition, enhancing development efficiency can be achieved by incorporating autonomous functions alongside automation. To achieve this, we developed an autonomous synthesis robot that harnesses the power of artificial intelligence (AI) and robotic technology to establish optimal synthetic recipes. Given a target molecule, our AI initially plans synthetic pathways and defines reaction conditions. It then iteratively refines these plans using feedback from the experimental robot, gradually optimizing the recipe. The system performance was validated by successfully determining synthetic recipes for three organic compounds, yielding that conversion rates that outperform existing references. Notably, this autonomous system is designed around batch reactors, making it accessible and valuable to chemists in standard laboratory settings, thereby streamlining research endeavors.

Advanced Compliant Anti-Gravity Robot System for Lumbar Stabilization Exercise Using Series Elastic Actuator.

Background: The lumbar stabilization exercise is one of the most recommended treatments in medical professionals for patients suffering from low back pain. However, because lumbar stabilization exercise is calisthenics, it is challenging to perform because of the body load of the elderly, disabled, and patients that lack muscle strength. Additionally, it interferes with the effect of exercise because it can strain parts of the body. Methods: To overcome them, a compliant anti-gravity rehabilitation proto-type device using the Series Elastic Actuator (SEA) was developed previously to provide quantitative assist force to the person, producing similar exercise effects with calisthenics. From an exercise experiment with 20 participants, it caused discomfort to participants during exercise owing to the non-ergonomic design of the previous device. Different muscle activation tendencies were observed between calisthenics and exercise using the device. For advanced technical solutions to clinical needs, which is exercise using the rehabilitation robot to produce a similar effect to calisthenics, the mechanical design of the rehabilitation robot was improved based on the previous device after receiving feedback from clinical trials and static analysis. For the safety of exercise using the robot, a cascade PID-PI controller was used to reduce the influence of friction and disturbance due to the external movement. Results: Surface electromyography(sEMG) signal from lumbar muscles showed desired monotonic reduction ratio and higher similarity results compared to the previous device, which proved the exercise effectiveness using the robot. Conclusion: The proposed robot is considered as a solution to a clinical need of lumbar rehabilitation for the elderly, disabled, and patients.

Weight lifting can facilitate appreciative comprehension for museum exhibits.

Appreciation of exhibits in a museum can be equated to a virtual experience of lives in the contexts originally surrounding the exhibits. Here we focus on the importance of weight information, and hence tested whether experiencing a weight during museum exhibit appreciation affects the beholders' satisfaction and recognition memory for the exhibits. An experiment was performed at a museum exhibiting skeletal preparations of animals. We used nine preparations and prepared four weight stimuli as weight cues in accordance with the actual weight of four of the preparations: Remaining five preparations was displayed without weight stimuli. In the cued condition, participants were asked to lift up the weight stimuli during their observation of the four exhibits. In the uncued condition, participants observed the exhibits without touching the weight stimuli. After observation of the exhibits, the participants responded to a questionnaire that measured their impressions of the exhibits and the museum, and performed a recognition test on the exhibits. Results showed that memory performance was better and viewing duration was longer with weight lifting instruction than without instruction. A factor analysis on the questionnaires revealed four factors (likeability, contentment, value, and quality). A path analysis showed indirect effects of viewing duration on memory performance and willingness-to-pay (WTP) for the museum appreciation through the impression factors. Our findings provide insight into a new interactive exhibition that enables long appreciation producing positive effects on visitors' impression, memory, and value estimation for exhibits.