A novel method of evaluating the non-invasive tear film break-up time and progression of corneal opacification in dogs using imaging video.

This study aimed to determine the correlation of the parameters that indicate the status of the ocular surface with the prognosis of corneal opacification. Fifty dogs (96 eyes) were examined using a grid-line illuminator (non-invasive tear film break-up time (NIBUT)). Thirty dogs (54 eyes) were included in the final analysis based on the criteria. The NIBUT and tear film break-up time (TFBUT) results of the eyes included in the study were divided into three groups: Group 1 (< 5 s), Group 2 (5 to <10 s), and Group 3 (≥ 10 s). The Schirmer's tear Test 1 (STT-1) results of the included patients were also divided into three groups: Group 1 (< 5 mm/min), Group 2 (5 to <10 mm/min), and Group 3 (≥ 10 mm/min). The corneal opacity grades are divided into four scores, ranging from 0 to 3. The corneal opacity grade score (COS) of 0 indicates a completely clear cornea or only a trace of opacity. COS of 1, 2, 3 indicate the presence of a prominent corneal opacity that does not interfere with the visualization of the fine iris details, the opacity obscures the visibility of the iris and lens details and severe obstruction of the intraocular structure visibility, respectively. The mean difference in COS during the follow-ups for each group of NIBUT were 0.61 ± 0.92 (n = 28), 0.10 ± 0.32 (n = 10), 0.19 ± 0.40 (n = 16). The NIBUT groups were significantly correlated with COS (p-value = 0.073) at a 10% level of significance. Post-hoc test at a 10% level of significance revealed significant correlations between Groups 1 and 2 (p-value = 0.041) and between Groups 1 and 3 (p-value 0.104). Although the TFBUT and STT-1 groups did not show any significant correlation with COS. Eyes with NIBUT of <5 s were found to have a significantly higher chance of increased COS compared with eyes with NIBUT of >5 s in the grid-line illumination plate NIBUT test. Among NIBUT, STT-1, and TFBUT, NIBUT was the only test that showed significant associations with the changes in COS.

Analyses of Time Series InSAR Signatures for Land Cover Classification: Case Studies over Dense Forestry Areas with L-Band SAR Images.

As demonstrated in prior studies, InSAR holds great potential for land cover classification, especially considering its wide coverage and transparency to climatic conditions. In addition to features such as backscattering coefficient and phase coherence, the temporal migration in InSAR signatures provides information that is capable of discriminating types of land cover in target area. The exploitation of InSAR signatures was expected to provide merits to trace land cover change in extensive areas; however, the extraction of suitable features from InSAR signatures was a challenging task. Combining time series amplitudes and phase coherences through linear and nonlinear compressions, we showed that the InSAR signatures could be extracted and transformed into reliable classification features for interpreting land cover types. The prototype was tested in mountainous areas that were covered with a dense vegetation canopy. It was demonstrated that InSAR time series signature analyses reliably identified land cover types and also recognized tracing of temporal land cover change. Based on the robustness of the developed scheme against the temporal noise components and the availability of advanced spatial and temporal resolution SAR data, classification of finer land cover types and identification of stable scatterers for InSAR time series techniques can be expected. The advanced spatial and temporal resolution of future SAR assets combining the scheme in this study can be applicable for various important applications including global land cover changes monitoring.

Friedel-Crafts alkylation with α-bromoarylacetates for the preparation of enantioenriched 2,2-diarylethanols.

Highly enantioenriched 2,2-diarylethanols can be efficiently synthesized through the Friedel-Crafts alkylation of (hetero)arenes with configurationally labile α-bromoarylacetates. The substitution of highly diastereoenriched α-bromoarylacetates occurs in the presence of AgOTf, and the subsequent reduction affords diverse 2,2-diarylethanols with high yields and enantioselectivities up to 99 : 1 er. In addition, the application of this asymmetric synthetic methodology to the preparation of highly enantioenriched dihydrobenzofuran and indoline derivatives is demonstrated.