1.
Chem Biol Drug Des
; 89(1): 61-66, 2017 Jan.
Artículo
en Inglés
| MEDLINE
| ID: mdl-27647631
RESUMEN
Enzymatic glycosylation of sterols/steroids with glycosyltransferase HP0421 shows protein plasticity on generation of configurationally rare steryl-α-glucosides. Investigation of trans-androsteronyl-α-glucoside on tamoxifen-treated MCF-7 breast cancer cells shows dose-dependent depression of cell viability and enhanced drug effectiveness, illustrating a new avenue for the production of novel steryl-α-glucosides with useful biological activities.