Neural Dynamics During the Generation and Evaluation of Creative and Non-Creative Ideas.

What are the neural dynamics that drive creative thinking? Recent studies have provided much insight into the neural mechanisms of creative thought. Specifically, the interaction between the executive control, default mode, and salience brain networks has been shown to be an important marker of individual differences in creative ability. However, how these different brain systems might be recruited dynamically during the two key components of the creative process-generation and evaluation of ideas-remains far from understood. In the current study we applied state-of-the-art network neuroscience methodologies to examine the neural dynamics related to the generation and evaluation of creative and non-creative ideas using a novel within-subjects design. Participants completed two functional magnetic resonance imaging sessions, taking place a week apart. In the first imaging session, participants generated either creative (alternative uses) or non-creative (common characteristics) responses to common objects. In the second imaging session, participants evaluated their own creative and non-creative responses to the same objects. Network neuroscience methods were applied to examine and directly compare reconfiguration, integration, and recruitment of brain networks during these four conditions. We found that generating creative ideas led to significantly higher network reconfiguration than generating non-creative ideas, whereas evaluating creative and non-creative ideas led to similar levels of network integration. Furthermore, we found that these differences were attributable to different dynamic patterns of neural activity across the executive control, default mode, and salience networks. This study is the first to show within-subject differences in neural dynamics related to generating and evaluating creative and non-creative ideas.

Conceptual structure of emotions.

Theories of semantic organization have historically prioritized investigation of concrete concepts pertaining to inanimate objects and natural kinds. As a result, accounts of the conceptual representation of emotions have almost exclusively focused on their juxtaposition with concrete concepts. The present study aims to fill this gap by deriving a large set of normative feature data for emotion concepts and assessing similarities and differences between the featural representation of emotion, nonemotion abstract, and concrete concepts. We hypothesized that differences between the experience of emotions (e.g., happiness and sadness) and the experience of other abstract concepts (e.g., equality and tyranny), specifically regarding the relative importance of interoceptive states, might drive distinctions in the dimensions along which emotion concepts are represented. We also predicted, based on constructionist views of emotion, that emotion concepts might demonstrate more variability in their representation than concrete and other abstract concepts. Participants listed features which we coded into discrete categories and contrasted the feature distributions across conceptual types. Analyses revealed statistically significant differences in the distribution of features among the category types by condition. We also examined variability in the features generated, finding that, contrary to expectation, emotion concepts were associated with less variability. Our results reflect subtle differences between the structure of emotion concepts and the structure of, not only concrete concepts, but also other abstract concepts. We interpret these findings in the context of our sample, which was restricted to native English speakers, and discuss the importance of validating these findings across speakers of different languages. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Large-scale network connectivity as a predictor of age: Evidence across the adult lifespan from the Cam-CAN data set.

Changes in brain connectivity patterns as a function of age have been recently proposed to underlie differences in cognitive abilities between young and older adults. These shifts track patterns of increased functional coupling between the executive control network (ECN)-a network of prefrontal and parietal areas that is broadly implicated in externally directed attention and cognitive control-and default mode network (DMN) regions-most commonly associated with internally directed cognitive activity. Although age-related changes in ECN-DMN coupling are well characterized, the contributions of the salience network are less clear. Furthermore, given the salience network's crucial role in arbitrating ECN-DMN functional connectivity, it is important to understand its contribution throughout the adult lifespan. Here, we used the data from a large cohort (N = 547) of participants from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) database (18-88 years old) to investigate first whether resting-state ECN-DMN functional connectivity predicts age. We further examined how connectivity between ECN, DMN, and salience network regions impacts the hypothesized age-related increased connectivity between ECN and DMN areas. Multiple regression analyses revealed that connectivity between dorsolateral and ventromedial prefrontal cortex and parietal regions, including the precuneus, accounted for a significant portion of age variability and that the inclusion of connectivity between orbitofrontal insula, anterior insula, and anterior cingulate regions of the salience network improved the models' explanatory power. Additional age cohort analyses further highlighted that these relationships vary across the lifespan. We discuss how these findings expand on our current understanding of the variations in large-scale intrinsic network connectivity as a function of healthy aging. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Transcranial Direct Current Stimulation Over the Prefrontal Cortex in Depression Modulates Cortical Excitability in Emotion Regulation Regions as Measured by Concurrent Functional Magnetic Resonance Imaging: An Exploratory Study.

BACKGROUND: A well-established impaired top-down network for effortful emotion regulation (ER) in major depressive disorder (MDD) includes the dorsal and ventromedial prefrontal cortex (PFC) and the amygdala. Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulation method that has been used successfully to induce mood changes in MDD. Despite reliable findings, little is known regarding the precise effects of tDCS on cortical excitability in vivo in depression and how such changes relate to ER. Here, we addressed this question by combining-for the first time in a psychiatric sample-tDCS with functional magnetic resonance imaging in a single-blind randomized design. METHODS: We applied anodal tDCS over the left PFC (area F3 per the 10/20 system) together with cathodal tDCS over the right PFC (F4) or sham tDCS during functional magnetic resonance imaging in patients with moderate to severe MDD (n = 20) and gender- and age-matched control subjects (n = 20). Participants performed 2 runs of an ER task prior to tDCS and 2 runs of the task during tDCS, which was administered at 1.5 mA with 5-cm × 5-cm electrodes. RESULTS: Whole-brain, region of interest, and connectivity analyses revealed an impaired ER network in patients with MDD prior to stimulation. Active anodal tDCS over the left (with concurrent cathodal stimulation of the right) PFC during reappraisal of negative stimuli upregulated activity in ventromedial PFC, which was predictive of gains in reappraisal performance during stimulation for the patients with MDD. CONCLUSIONS: The results of this study offer insights into the mechanisms of action of tDCS and support its potential as a treatment for depression.

Augmenting ideational fluency in a creativity task across multiple transcranial direct current stimulation montages.

Neuroimaging and transcranial direct current stimulation (tDCS) research has revealed that generating novel ideas is associated with both reductions and increases in prefrontal cortex (PFC) activity, and engagement of posterior occipital cortex, among other regions. However, there is substantial variability in the robustness of these tDCS-induced effects due to heterogeneous sample sizes, different creativity measures, and methodological diversity in the application of tDCS across laboratories. To address these shortcomings, we used twelve different montages within a standardized tDCS protocol to investigate how altering activity in frontotemporal and occipital cortex impacts creative thinking. Across four experiments, 246 participants generated either the common or an uncommon use for 60 object pictures while undergoing tDCS. Participants also completed a control short-term memory task. We applied active tDCS for 20 min at 1.5 mA through two 5 cm × 5 cm electrodes over left or right ventrolateral prefrontal (areas F7, F8) or occipital (areas O1, O2) cortex, concurrent bilateral stimulation of these regions across polarities, or sham stimulation. Cathodal stimulation of the left, but not right, ventrolateral PFC improved fluency in creative idea generation, but had no effects on originality, as approximated by measures of semantic distance. No effects were obtained for the control tasks. Concurrent bilateral stimulation of the ventrolateral PFC regardless of polarity direction, and excitatory stimulation of occipital cortex did not alter task performance. Highlighting the importance of cross-experimental methodological consistency, these results extend our past findings and contribute to our understanding of the role of left PFC in creative thinking.

Effects of unilateral tDCS over left prefrontal cortex on emotion regulation in depression: Evidence from concurrent functional magnetic resonance imaging.

Major depressive disorder (MDD) is the most common mood disorder and a primary cause of disability worldwide. MDD symptomatology entails disturbances in emotion regulation, namely one's ability to modify the intensity and duration of emotional reactions towards affective events. Transcranial direct current stimulation (tDCS) has emerged as a promising treatment for MDD. Yet, positive tDCS outcomes vary across studies, while the precise effects of the procedure for cortical excitability in MDD during emotion regulation remain largely unexplored. Here, we leveraged functional magnetic resonance imaging (fMRI)-compatible tDCS technology to examine the functional consequences of a unilateral anodal tDCS montage at 1.5 mA over left PFC (area F3; with the reference electrode over an extracephalic location) for brain activity during an emotion-regulation task in MDD patients and age-matched healthy control subjects. Our results revealed down-regulation of negative emotions in the right amygdala and visual cortex of healthy controls but not MDD patients prior to stimulation, the degree of which correlated with the magnitude of the participants' reappraisal scores. TDCS did not elicit significant changes in neural activation patterns for either group. These findings contribute to the literature on the pathophysiology of MDD by showing that a key disturbance in the disorder entails the ineffective down-regulation of activity not only within the amygdala, but also within visual cortical areas in response to negative information. Further, these results suggest that relative to bifrontal tDCS montages, unilateral stimulation of moderate intensity over left PFC may not be sufficient to elicit therapeutic effects for MDD.

Using neuroscience techniques to understand and improve design cognition.

Cognitive neuroscience research has traditionally focused on understanding the brain mechanisms that enable cognition by means of experimental laboratory tasks. With a budding literature, there is growing interest in the application of the related methods and findings to real-world settings. In this opinion paper we explore the potential and promise of employing current cognitive neuroscience methodologies in the field of design. We review recent evidence from preliminary studies that have employed such methods toward identifying the neural bases of design thinking and discuss their impact and limitations. Further, we highlight the importance of pairing neuroscience methods with well-established behavioral paradigms during ecologically-valid, real-world design tasks. Experimental investigations that meet these requirements can generate powerful datasets of neurocognitive measures that can offer new insights into the complex cognitive and brain systems enabling design thinking. We argue that this new knowledge can lead to the development and implementation of new techniques toward cultivating and improving design thinking in design education and professional practice.

Differences in brain activity patterns during creative idea generation between eminent and non-eminent thinkers.

An influential model of the neural mechanisms of creative thought suggests that creativity is manifested in the joint contributions of the Default Mode Network (DMN; a set of regions in the medial PFC, lateral and medial parietal cortex, and the medial temporal lobes) and the executive networks within the dorsolateral PFC. Several empirical reports have offered support for this model by showing that complex interactions between these brain systems account for individual differences in creative performance. The present study examined whether the engagement of these regions in idea generation is modulated by one's eminence in a creativity-related field. Twenty (n â€‹= â€‹20) healthy eminent creators from diverse fields of expertise and a 'smart' comparison group of sixteen (n â€‹= â€‹16) age- and education-matched non-eminent thinkers were administered a creative generation task (an adaptation of the Alternative Uses Task) and a control perceptual task, while undergoing functional magnetic resonance imaging (fMRI). The participants' verbal responses were recorded through a noise-canceling microphone and were later coded for fluency and accuracy. Behavioral and fMRI analyses revealed commonalities between groups, but also distinct patterns of activation in default mode and executive brain regions between the eminent and the non-eminent participants during creative thinking. We interpret these findings in the context of the well-documented contributions of these regions in the generation of creative ideas as modulated, in this study, by participants' creative eminence.

Differences in brain morphometry associated with creative performance in high- and average-creative achievers.

Nearly everyone has the ability for creative thought. Yet, certain individuals create works that propel their fields, challenge paradigms, and advance the world. What are the neurobiological factors that might underlie such prominent creative achievement? In this study, we focus on morphometric differences in brain structure between high creative achievers from diverse fields of expertise and a 'smart' comparison group of age-, intelligence-, and education-matched average creative achievers. Participants underwent a high-resolution structural brain imaging scan and completed a series of intelligence, creative thinking, personality, and creative achievement measures. We examined whether high and average creative achievers could be distinguished based on the relationship between morphometric brain measures (cortical area and thickness) and behavioral measures. Although participants' performance on the behavioral measures did not differ between the two groups aside from creative achievement, the relationship between posterior parietal cortex morphometry and creativity, intelligence, and personality measures depended on group membership. These results suggest that extraordinary creativity may be associated with measurable structural brain differences, especially within parietal cortex.

Safety analysis of work zone complexity with respect to driver characteristics - A simulator study employing performance and gaze measures.

Driving is a complex task that consists of several physical (motor-related) and physiological (biological changes within the body) processes occurring simultaneously. The complexity of the task depends on several factors, but this research focuses on work zone configurations and their effect on driver performance and gaze behavior. The increase in work zone fatalities in the United States between 2015 and 2018 coupled with the limited literature of driver behavior in these complex environments requires a more comprehensive study. Given the nature of these crashes, typically lane departures, gaze behavior provided an additional physiological dimension to the present research. A framework that comprises of the interactions between driver characteristics, mental workload, and situation awareness, with longitudinal control, lateral control, and gaze behavior is proposed. Crash analysis and a simulator study with 90 participants were carried out to investigate the performance and gaze-based changes with respect to various work zone configurations. Distracted driving was also studied by including a secondary task. The results showed a significant interaction between the longitudinal control and the standard deviation of horizontal gaze position in predicting lateral control. Also, significant differences in lateral control and horizontal gaze variations were observed between genders. Female drivers showed lower lateral position deviations and lower horizontal gaze variability. This was a key finding given the inherently higher number of work zone crashes involving male drivers. Placing work zone barriers further away, by up to one meter from pavement edges, could significantly decrease mental workload and improve safety in work zones.

Emotion Regulation Flexibility: Gender Differences in Context Sensitivity and Repertoire.

Emotion regulation (ER) has been conceptualized as processes through which individuals modulate their emotions consciously and non-consciously to respond appropriately to environmental demands. Emotions can be regulated in many ways and specific strategies may have differing efficacy across situations and individuals. The importance of flexibility in implementing ER strategies has been highlighted in many current models. In this study, we investigated gender differences in two regulatory processes, context sensitivity and repertoire using a novel coding system for ER strategy classification. The results revealed that women consistently used more strategies than men and were more flexible in the implementation of those strategies. These findings validate our novel coding system for ER strategy classification. They further highlight the importance of a comprehensive examination of gender differences in ER processes for understanding the nuances of ER and developing effective treatments for psychopathologies characterized by ER deficits.

Using Transcranial Direct Current Stimulation to Enhance Creative Cognition: Interactions between Task, Polarity, and Stimulation Site.

Creative cognition is frequently described as involving two primary processes, idea generation and idea selection. A growing body of research has used transcranial direct current stimulation (tDCS) to examine the neural mechanisms implicated in each of these processes. This literature has yielded a diverse set of findings that vary depending on the location and type (anodal, cathodal, or both) of electrical stimulation employed, as well as the task's reliance on idea generation or idea selection. As a result, understanding the interactions between stimulation site, polarity and task demands is required to evaluate the potential of tDCS to enhance creative performance. Here, we review tDCS designs that have elicited reliable and dissociable enhancements for creative cognition. Cathodal stimulation over the left inferior frontotemporal cortex has been associated with improvements on tasks that rely primarily on idea generation, whereas anodal tDCS over left dorsolateral prefrontal cortex (DLPFC) and frontopolar cortex has been shown to augment performance on tasks that impose high demands on creative idea selection. These results highlight the functional selectivity of tDCS for different components of creative thinking and confirm the dissociable contributions of left dorsal and inferior lateral frontotemporal cortex for different creativity tasks. We discuss promising avenues for future research that can advance our understanding of the effectiveness of tDCS as a method to enhance creative cognition.

Motor experience influences object knowledge.

An object's perceived readiness-for-action (e.g., its size, the degree of rotation from its canonical position, the user's viewpoint) can influence semantic knowledge retrieval. Yet, the organization of object knowledge may also be affected by body-specific sensorimotor experiences. Here, we investigated whether people's history of performing motor actions with their hands influences the knowledge they store and retrieve about graspable objects. We compared object representations between healthy right- and left-handers (Experiment 1), and between unilateral stroke patients, whose motor experience was changed by impairment of either their right or left hand (Experiment 2). Participants saw pictures of graspable everyday items with the handles oriented toward either the left or right hand, and they generated the type of grasp they would employ (i.e., clench or pinch) when using each object, responding orally. In both experiments, hand dominance and object orientation interacted to predict response times. In Experiment 1, judgments were fastest when objects were oriented toward the right hand in right-handers, but not in left-handers. In Experiment 2, judgments were fastest when objects were oriented toward the left hand in patients who had lost the use of their right hand, even though these patients were right-handed prior to brain injury. Results suggest that at least some aspects of object knowledge are determined by motor experience, and can be changed by new patterns of motor experience. People with different bodily characteristics, who interact with objects in systematically different ways, form correspondingly different neurocognitive representations of the same common objects. (PsycINFO Database Record

Attention to Distinct Goal-relevant Features Differentially Guides Semantic Knowledge Retrieval.

A critical aspect of conceptual knowledge is the selective activation of goal-relevant aspects of meaning. Although the contributions of ventrolateral prefrontal and posterior temporal areas to semantic cognition are well established, the precise role of posterior parietal cortex in semantic control remains unknown. Here, we examined whether this region modulates attention to goal-relevant features within semantic memory according to the same principles that determine the salience of task-relevant object properties during visual attention. Using multivoxel pattern analysis, we decoded attentional referents during a semantic judgment task, in which participants matched an object cue to a target according to concrete (i.e., color, shape) or abstract (i.e., function, thematic context) semantic features. The goal-relevant semantic feature participants attended to (e.g., color or shape, function or theme) could be decoded from task-associated cortical activity with above-chance accuracy, a pattern that held for both concrete and abstract semantic features. A Bayesian confusion matrix analysis further identified differential contributions to representing attentional demands toward specific object properties across lateral prefrontal, posterior temporal, and inferior parietal regions, with the dorsolateral pFC supporting distinctions between higher-order properties and the left intraparietal sulcus being the only region supporting distinctions across all semantic features. These results are the first to demonstrate that patterns of neural activity in the parietal cortex are sensitive to which features of a concept are attended to, thus supporting the contributions of posterior parietal cortex to semantic control.

Anodal transcranial direct current stimulation over right dorsolateral prefrontal cortex alters decision making during approach-avoidance conflict.

Approach-avoidance conflict (AAC) refers to situations associated with both rewarding and threatening outcomes. The AAC task was developed to measure AAC decision-making. Approach behavior during this task has been linked to self-reported anxiety sensitivity and has elicited anterior cingulate, insula, caudate and right dorsolateral prefrontal cortex (dlPFC) activity, with right lateral PFC tracking the extent of approach behavior. Guided by these results, we used excitatory transcranial direct current stimulation (tDCS) to demonstrate the causal involvement of right dlPFC in AAC decision-making. Participants received anodal tDCS at 1.5mA over either left or right dlPFC or sham stimulation, while performing the AAC task and a control short-term memory task. Analyses of variance (ANOVA) revealed that for individuals with high anxiety sensitivity excitatory right (but not left or sham) dlPFC stimulation elicited measurable decreases in approach behavior during conflict. Excitatory left (but not right or sham) dlPFC simulation improved performance on the control task. These results support a possible asymmetry between the contributions of right and left dlPFC to AAC resolution during emotional decision-making. Increased activity in right dlPFC may contribute to anxiety-related symptoms and, as such, serve as a neurobehavioral target of anxiolytic treatments aiming to decrease avoidance behavior.

Correction: Neural Processing of Emotional Musical and Nonmusical Stimuli in Depression.

[This corrects the article DOI: 10.1371/journal.pone.0156859.].

Assessing Cognitive and Affective Empathy Through the Interpersonal Reactivity Index: An Argument Against a Two-Factor Model.

One aspect of higher order social cognition is empathy, a psychological construct comprising a cognitive (recognizing emotions) and an affective (responding to emotions) component. The complex nature of empathy complicates the accurate measurement of these components. The most widely used measure of empathy is the Interpersonal Reactivity Index (IRI). However, the factor structure of the IRI as it is predominantly used in the psychological literature differs from Davis's original four-factor model in that it arbitrarily combines the subscales to form two factors: cognitive and affective empathy. This two-factor model of the IRI, although popular, has yet to be examined for psychometric support. In the current study, we examine, for the first time, the validity of this alternative model. A confirmatory factor analysis showed poor model fit for this two-factor structure. Additional analyses offered support for the original four-factor model, as well as a hierarchical model for the scale. In line with previous findings, females scored higher on the IRI than males. Our findings indicate that the IRI, as it is currently used in the literature, does not accurately measure cognitive and affective empathy and highlight the advantages of using the original four-factor structure of the scale for empathy assessments.

Corrigendum.

Chrysikou, E. G., & Thompson, W. J. (2016). Assessing cognitive and affective empathy through the interpersonal reactivity index: An argument against a two-factor model. Assessment, 23(6), 769-777. doi:1073191115599055.