[Effects of leuzea tincture and leveton on humoral immunity of athletes]. / Vliianie nastoiki levzei i levetona na gumoral'nyi immunitet sportsmenov.

The effect of 20-day administration of ectisten-containing tincture of leuzea and leveton on humoral immunity of track and field runners for distances of 5,000 and 10,000 m was studied. Intensive cyclic physical activity induced significant decrease of IgG and IgA in blood serum of the athletes as well as the complement C3 component on the 10th and 20th days. Both drugs contributed to restoration of the lowered IgG, IgA, and C3 concentration. The effect of leveton was more pronounced. The working capacity of the athletes grew by 10 to 15% in this case.

[Stabilizing effect of the antioxidants alpha-tocopherol and sodium selenite following phospholipase damage to mitochondrial membranes in a model of anoxia]. / Stabiliziruiushchee deistvie antioksidantov alpha-tokoferola i selenita natriia pri fosfolipaznom povrezhdenii membran mitokhondrii v usloviiakh model'noi anoksii.

The kinetics of the free fatty acids accumulation in membranes of isolated mitochondria of the brain, heart and liver of rats, with their incubation in a medium containing no substrates and ATP, was studied. The intensity of the phospholipase damage, measured by the rate of free fatty acids accumulation, augments in the sequence of: the liver-heart-brain. The amassment of fatty acids in the mitochondrial membranes is shown to give place to their penetration into the inner space of the mitochondria. A relationship between the content of the intramitochondrial calcium and the concentration of free fatty acids in in the membranes, on the one hand, and the degree of passive swelling of the cardiac mitochondria, on the other, was revealed. It is suggested that the free fatty acids or their derivatives act as carriers of calcium to the mitochondrial membrane. A preliminary administration to rats of the vitamin E and sodium selenite protects the mitochondria of the heart against the phospholipase damage. These agents display a synergic action and are effective with administration of physiological doses. It is presumed that the protective action of these substances is due to the stabilization of biological membranes.

[The effect of hydrocortisone and 6-methylprednisolone on the cytoplasmic membrane of rat thymocytes in an vitro system]. / Vliianie gidrokortizona i 6-metilprednizolona na tsitoplazmaticheskuiu membrany timotsitov krys v opytakh in vitro.

Hydrocortisone and 6-methylprednisolone increase the binding constant of anilinenaphthalene-sulphonate (ANS) with the cytoplasmatic thymocytes membrane following a 2--3 hour long incubation in vitro. Over the same period these compounds stimulate the liberation of potassium ions from the thymocytes. A supravital staining of the thymocytes with Trypan blue did not change during the whole time of the hormones action. The effect of the hydrocortisone and 6-methylprednisolone action on the ANS binding constant and potassium release depende upon the duration of incubation and concentration of the steriod in the medium. Hydrocortisone produces a greater influence than does 6-methylprednisolone.