Sleep disturbance in relation to health-related quality of life in adults: the Fels Longitudinal Study.

OBJECTIVE: Sleep disturbances are prevalent problems in the general population. Symptoms of insomnia can impact various physical and mental conditions. Furthermore, sleep disturbances may worsen the quality of life independently of co-occurring medical conditions. In this study, we examined the relationships between self-reported sleep disturbance symptoms and health-related quality of life measures in the Fels Longitudinal Study. DESIGN: Cross-sectional study. PARTICIPANTS: A total of 397 adults (175 men and 222 women) aged 40 years and older were included in the present study. MEASUREMENTS: Three self-reported sleep disturbance measures (difficulty falling asleep, nocturnal awakenings and maintaining sleep, and daytime tiredness) were collected between 2003 and 2006. Health-related quality of life measures were assessed using the Medical Outcomes Survey Short Form (SF)-36. Socio-demographic status (marital status, employment status, and education) and current medical conditions were collected from participants during study visits. RESULTS: Individuals who reported frequent sleep disturbances showed significantly worse quality of life on all SF-36 subscales examined. The odds ratio (OR) ranged from 1.71 to 18.32 based on symptoms of insomnia across seven SF-36 domains in analyses adjusted for significant covariates influencing quality of life. Participants with severe sleep disturbances (both sleep problems and daytime impairment) showed generally higher odds of reporting poor SF-36 scores (adjusted ORs; 5.88 - 17.09) compared to participants with no problems. CONCLUSION: Sleep disturbance is comprehensively and independently associated with poor health-related quality of life in middle-aged and older adults.

Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives.

Sarcopenia is a loss of muscle protein mass and loss of muscle function. It occurs with increasing age, being a major component in the development of frailty. Current knowledge on its assessment, etiology, pathogenesis, consequences and future perspectives are reported in the present review. On-going and future clinical trials on sarcopenia may radically change our preventive and therapeutic approaches of mobility disability in older people.

The availability of body composition reference data for the elderly.

A significant public health issue is the nutritional, functional and health status of the elderly, many of whom live to very old ages, and three-quarters are living in developing countries. The assessment of health and nutritional status for the elderly needs improving in order to reduce health care costs. Health, function, disease and disability are associated with amounts of bone, fat and muscle in the body s composition. The ability to screen elderly persons for osteoporosis, obesity or sarcopenia requires normal distributions of measures of stature, weight and body composition in old age. Distribution statistics and selected percentiles for stature and weight are available from national health surveys in numerous countries. There are also numerous sets of body composition data collected from elderly persons around the world. These data sets provide important and valid descriptive information as a supplement to national reference data sets. The largest available data set for the elderly is the NHANES III, but in terms of numbers, the NHANES III sample of elderly is limited to availability of the 25th and 75th percentiles levels for stature, weight and BMI from 60 to 90 years of age for non-Hispanic Whites, and from 60 to 79 years of age for non-Hispanic Blacks and Mexican Americans.