RESUMEN
Further study of one of the fractions from the wood of Artocarpus elasticus furnished two new prenylated flavonoids artelastocarpin and carpelastofuran as well as ethyl 2,4-dihydroxybenzoate. The two flavonoids and the prenylated flavonoids artelastin, artelastochromene, artelasticin, artocarpesin, and cyclocommunin isolated earlier from this species were tested for cytotoxicity in vitro against three human cell lines. All seven flavonoids were active, the cytotoxic effect varying from strong to moderate and with artelastin showing the most potent activity.
Asunto(s)
Antineoplásicos Fitogénicos/farmacología , Flavonoides/farmacología , Moraceae , Neoplasias/tratamiento farmacológico , Antineoplásicos Fitogénicos/química , Neoplasias de la Mama/tratamiento farmacológico , Neoplasias de la Mama/patología , Flavonoides/química , Humanos , Hidroxibenzoatos/química , Hidroxibenzoatos/farmacología , Neoplasias Renales/tratamiento farmacológico , Neoplasias Renales/patología , Espectroscopía de Resonancia Magnética , Melanoma/tratamiento farmacológico , Melanoma/patología , Neoplasias/patología , Neopreno/química , Neopreno/farmacología , Neopreno/uso terapéutico , Tallos de la Planta/química , Células Tumorales CultivadasRESUMEN
Nine xanthones, including 3-(4-hydroxy-3-metnylbutyl)-4,8-dihydroxyxanthone, were isolated from the wood of a Thai collection of CALOPHYLLUM TEYSMANNII Miq. var. INUPHYLLOIDE (King) P. Stephen. Immunomodulatory activities of eight of these have been investigated.