The significance of anthropometric and endocrine parameters in ovulation induction with clomiphene citrate in women with polycystic ovary syndrome.

OBJECTIVES: To investigate factors associated with the response to ovarian stimulation in patients with polycystic ovary syndrome. Methods: The records of patients with polycystic ovary syndrome and infertility who underwent ovulation induction with clomiphene citrate were reviwed between January 2011 and December 2014 in Etlik Zübeyde Hanim Women's Health Training and Research Hospital Ankara, Turkey. The anthropometric and endocrine factors of patients who were resistant to treatment at a dose of 150 mg/day (n=84) were compared with those who responded with growth of at least one graaffian follicle at a dose of 50 mg/day (n=342). Results: Of the parameters examined, body mass index, luteinizing hormone level, and luteinizing hormone/follicle stimulating hormone ratio were significantly higher in the clomiphene citrate-resistant group compared with the responsive group. Conclusion: Reproductive treatment in patients with polycystic ovary syndrome show different outcomes. Significantly higher body mass index, luteinizing hormone level, and luteinizing hormone/follicle stimulating hormone ratio observed in clomiphene citrate resistant group can be a possible explanation for this impedance.

The value of ultrasonographic tubo-ovarian abscess morphology in predicting whether patients will require surgical treatment.

OBJECTIVE: To determine if the ultrasonographic morphology of a tubo-ovarian abscess (TOA) could be used to predict if a patient will require surgical treatment. METHOD: A retrospective cohort study reviewed medical records from patients diagnosed with TOA via ultrasonography between January 2009 and January 2014 at a tertiary referral center in Turkey. Patients with pelvic inflammatory disease and an inflammatory adnexal mass, identified during sonographic examination, were included in the study. Ultrasonographic morphology, demographic characteristics, and clinical and laboratory findings were compared between patients who required surgical treatment and those who did not. RESULTS: Records were included from 164 patients; medical therapy was successful in 121 (73.8%) patients and 43 (26.2%) required surgical treatment. TOA morphology was identified, using ultrasonography, as unilocular cystic, complex multicystic mass, or pyosalpinx in 56 (34.1%), 73 (44.5%), and 35 (21.3%) patients, respectively. No correlation was present between ultrasonographic TOA morphology and patients requiring surgical treatment (all P>0.05). Multivariate analyses demonstrated that an abscess larger than 6.5 cm in size (P=0.027), fever at admission (P<0.001), and parity greater than two (P=0.026) were independent predictors of patients requiring surgical treatment for TOA. CONCLUSION: Although increased TOA size, fever at admission, and parity were associated with increased odds of patients with TOA requiring surgical treatment, ultrasonographic TOA morphology was not.

Association between bone mineral density and metabolic syndrome in Turkish women who were postmenopausal.

OBJECTIVE: To investigate the relationship between the parameters of metabolic syndrome and bone mineral density (BMD) at the femoral neck and lumbar spine in Turkish women who were postmenopausal. METHODS: In a retrospective study, the records of patients who were postmenopausal attending the Menopause Outpatient Clinic of a tertiary women's hospital in Ankara, Turkey, between January 1, 2014 and December 31, 2014 were retrieved. Patient's BMD at the lumbar spine and femoral neck were assessed using T-scores, and parameters of metabolic syndrome were evaluated in all patients. RESULTS: The records of 315 patients were retrieved. The mean age of patients was 55.63±6.14years (range 45-71 years). Metabolic syndrome was recorded in 92 (29.2%) patients. Following adjustment for age, patients with metabolic syndrome had higher T-scores at the femoral neck than patients without metabolic syndrome (-0.67±0.1 vs -1.15±0.06; P=0.001); there was no significant difference in T-scores at the lumbar spine (P=0.062). A Spearman correlation analysis of the entire study cohort demonstrated a negative association between high-density lipoprotein cholesterol and BMD at the lumbar spine and femoral neck (r=-0.12 and r=-0.15, respectively). CONCLUSION: Metabolic syndrome could have been partly associated with increased BMD in Turkish women who were postmenopausal.