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Am J Trop Med Hyg ; 105(6): 1698-1700, 2021 10 04.
Artículo en Inglés | MEDLINE | ID: mdl-34607312

RESUMEN

Corneal transplantation is the most frequent transplant worldwide. Tissue characteristics allow storage and transport, even between continents, increasing its accessibility around the world. Donor infection with Trypanosoma cruzi is not defined as a corneal discarding factor, although the transplant is not recommended preventively, as in any infectious diseases. Herein, by means of polymerase chain reaction (PCR) strategies, we analyzed parasite presence in ocular tissue from 10 deceased donors with Chagas diseases. Among them, positive findings were obtained in corneas, scleras, and eye muscle samples of three, two, and one donor, respectively. Moreover, among the six T. cruzi defined populations, TcV and TcVI parasites were found in some samples based on group-specific amplification strategies. Our findings point out the actual possibility of T. cruzi transmission due to corneal transplantation and makes donor's serological status knowledge mandatory regardless of graft provenance. Failing that, we suggest a posttransplant follow-up of recipients from seropositive donors.


Asunto(s)
Enfermedad de Chagas/transmisión , Córnea/parasitología , Músculos Oculomotores/parasitología , Esclerótica/parasitología , Trypanosoma cruzi/genética , Adulto , Anciano , Argentina , Trasplante de Córnea , ADN Protozoario/análisis , Femenino , Genotipo , Humanos , Masculino , Persona de Mediana Edad , Reacción en Cadena de la Polimerasa , Donantes de Tejidos , Obtención de Tejidos y Órganos
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