RESUMEN
Antlers are bony structures composed predominantly of primary osteons with unique mechanical properties due to their specific use by deer as weapon and shield. Antler bone fracture resistance has attracted prior scrutiny through experimental tests and theoretical models. To characterize antler mechanical properties, compression of cubes, or bending or tensioning of rectangular bars have been performed in the literature with variations in the protocols precluding comparisons of the data. Compression testing is a widely used experimental technique for determining the mechanical properties of specimens excised from cortical or cancellous regions of bone. However, the recommended geometry for compression tests is the cylinder, being more representative of the real performances of the material. The purpose of research was to report data for compressive strength and stiffness of antler cortical bone following current guidelines. Cylinders (n = 296) of dry antler cortical bone from either the main beam or the tines of Cervus elaphus, Rangifer tarandus, Cervus nippon and Damadama were tested. This study highlights the fact that compression of antler cortical bone cylinders following current guidelines is feasible but not applicable in all species. Standardization of the testing protocols could help to compare data from the literature. This study also confirms that sample localization has no effect on the mechanical properties, that sample density has a significant impact and allows enriching the knowledge of the mechanical properties of dry antler cortical bone.
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Cuernos de Venado , Ciervos , Animales , Hueso Cortical , Fuerza Compresiva , Fenómenos FísicosRESUMEN
Otitis media can be a consequence of chronic otitis externa and could represent a perpetuating factor. While the microbiota of the EEC in healthy dogs and in the presence of otitis externa has been described, only sparse information is available concerning the normal microbiota of the middle ear. The objective was to compare the tympanic bulla (TB) with the external ear canal (EEC) microbiota in healthy dogs. Six healthy experimental Beagle dogs were selected based on the absence of otitis externa, negative cytology and bacterial culture from the TB. Samples from the EEC and TB were collected directly after death using a total ear canal ablation and lateral bulla osteotomy. The hypervariable segment V1-V3 of the 16S rDNA was amplified and sequenced with a MiSeq Illumina. The sequences were analyzed by the Mothur software using the SILVA database. No significant differences between the EEC and TB microbiota for the Chao1 richness index (p = 0.6544), the Simpson evenness index (p = 0.4328) and the reciprocal Simpson alpha diversity (p = 0.4313) were noted (Kruskal-Wallis test). A significant difference (p = 0.009) for the Chao1 richness index between the right and left EEC was observed. The microbiota profile was similar in the EEC and the TB of the Beagles.
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OBJECTIVE: The aim of this study was to test the low sensitivity of the Allberg and Miles index to the stifle opening angle, evaluate the displacement of the patella after a Modified Maquet Technique using this index and assess the incidence of patellar luxation post-Modified Maquet Technique in dogs. STUDY DESIGN: Medical records were reviewed from 2012 to 2017. Allberg Miles index were determined for each stifle pre- and postoperatively, as well as the stifle joint opening of each case. Occurrence of patellar luxation was recorded. RESULTS: 137 stifles on 116 dogs were reviewed. The stifle opening angle did not influence the Allberg Miles index. Pre- and postoperative index showed a distal displacement of the patella after a Modified Maquet Procedure, especially at 135° of stifle opening angle. Only 1/137 cases demonstrated patellar luxation after the surgery. CONCLUSION: Based on our statistical analysis, we were able to conclude that within the maximum stifle opening angle range recorded in our series of cases; the Allberg Miles index variation was not significant. While patellar baja is clearly induced by the Modified Maquet Technique, the latter did not seem to predispose patients to post-operative patellar luxation in our study population.
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Enfermedades de los Perros , Luxación de la Rótula , Perros , Animales , Rótula/cirugía , Luxación de la Rótula/veterinaria , Rodilla de Cuadrúpedos/cirugía , Enfermedades de los Perros/cirugíaRESUMEN
OBJECTIVE: To describe a novel modified preputial urethrostomy with preservation of the local anatomy in 4 dogs. STUDY DESIGN: Short case series. ANIMALS: Four client-owned male dogs. METHODS: Dogs presented for dysuria and urethral obstruction and underwent a modified preputial urethrostomy as a salvage procedure after the failure of previous treatments. Urethral stenosis or tear was confirmed by cysto-urethrography in all dogs. The preputial urethrostomy involved anastomosis of the pelvic urethra with the preputial mucosa after caudal laparotomy, without dissection of the prepuce or amputation of the penis. Owner follow up was obtained by telephone interview. RESULTS: Urinary obstruction was due to urethral stenosis in 3 dogs and severe complications following perineal urethrostomy in 1 dog. The urinary obstruction was resolved in all dogs by the modified preputial urethrostomy. None of the dogs had signs of dysuria, urinary tract infection, or dermatitis immediately postoperatively. Two dogs showed signs of urinary incontinence from 15 days to 1 month postoperatively, which persisted throughout the follow-up period. CONCLUSION: A functional urethral stoma was obtained in all dogs. This technique may be an alternative to prepubic urethrostomy in male dogs.
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Enfermedades de los Perros , Obstrucción Uretral , Estrechez Uretral , Perros , Masculino , Animales , Uretra/cirugía , Estrechez Uretral/veterinaria , Disuria/veterinaria , Obstrucción Uretral/cirugía , Obstrucción Uretral/veterinaria , Pene/cirugía , Enfermedades de los Perros/cirugíaRESUMEN
Availability of graft materials to fill up osseous defects has always been a concern in orthopaedic surgeries. Deer antler material is a primary bone structure that is easy to collect and could serve as a xenograft. This study examines the behaviour of red deer antler trabecular cylinders in critical size distal femoral epiphyseal defects in 11 rabbits, and evaluates the effect of the decellularization protocols. Two preparation regimes (A and B) were used, with and without lipids and proteins. Radiographs were taken immediately after surgery and after euthanasia 12 weeks post-implantation. Histological evaluation was performed on non-decalcified 10-µm sections with a van Gieson picro-fuchsin staining protocol. A region of interest was defined for each histological section, evaluating the inflammatory reaction, the fibrosis process, and the osteogenesis. Each histological section was microradiographed to evaluate bone contact, presence of synostosis, remodelling and ossification processes. All antler cylinders were successfully implanted. Final radiographic analysis demonstrated osteointegration of most implants at various stages. Light to moderate inflammation around the grafts was noted with only one case showing full encapsulation. A variable degree of intimacy between implant and host bone was evidenced, with bone remodelling and osteogenesis of various intensity being present in all implanted sites. No differences were found between group A and B. Removal of lipids and proteins in the grafts surprisingly did not seem to matter. Decellularization and sterilization protocols may be advocated. Although it presents several limitations, this study shows some promising results regarding antler trabecular bone osteointegration.
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Cuernos de Venado/química , Remodelación Ósea , Hueso Esponjoso/trasplante , Ciervos , Osteogénesis , Conejos/cirugía , Trasplante Heterólogo/instrumentación , Animales , Masculino , Modelos AnimalesRESUMEN
OBJECTIVES: To determine whether there is a benefit of using pre- and postoperative antacid treatment in dogs undergoing surgery for brachycephalic syndrome. To assess the use of an obstruction manoeuvre during endoscopy for the detection of dynamic gastro-oesophageal junction abnormalities. MATERIALS AND METHODS: Thirty-six client-owned brachycephalic dogs were prospectively included in a randomised trial. Antacid treatment was randomly prescribed in 18 dogs before and after surgery while the other 18 dogs did not receive any gastrointestinal medical treatment. At presentation, at the time of surgery and at recheck, digestive clinical signs and gastro-oesophageal junction abnormalities were assessed using specific scores. Gastro-oesophageal junction abnormalities were assessed during endoscopy in standard conditions as well as during endotracheal tube obstruction. This manoeuvre was also applied in an unrelated control group. RESULTS: The results suggest a beneficial effect of antacid treatment on the improvement of digestive clinical signs and lesions in dogs with brachycephalic syndrome undergoing surgery. At postsurgical control 83% of dogs had a digestive clinical score ≤1 in the treated group in contrast to 44% in the non-treated group and 39% of dogs had a gastro-oesophageal abnormalities score (during obstruction manoeuvre) ≤1 in the treated group in contrast to 16.7% in the non-treated group. The use of the obstruction manoeuvre during endoscopic assessment in a control group revealed that gastro-oesophageal junction movements are negligible in healthy animals. CLINICAL SIGNIFICANCE: The addition of antacid treatment during the pre- and postoperative period for brachycephalic dogs undergoing surgery may result in a faster and greater improvement in treated dogs. The obstruction manoeuvre is an interesting technique to improve detection of gastro-oesophageal junction abnormalities.
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Obstrucción de las Vías Aéreas , Craneosinostosis , Enfermedades de los Perros , Enfermedades del Esófago , Obstrucción de las Vías Aéreas/veterinaria , Animales , Craneosinostosis/complicaciones , Craneosinostosis/diagnóstico , Craneosinostosis/cirugía , Craneosinostosis/veterinaria , Enfermedades de los Perros/diagnóstico , Enfermedades de los Perros/cirugía , Perros , Enfermedades del Esófago/veterinariaRESUMEN
OBJECTIVE: To compare the isoflurane-sparing effects of sufentanil-lidocaine-ketamine (SLK) and fentanyl-lidocaine-ketamine (FLK) infusions in dogs undergoing total ear canal ablation and lateral bulla osteotomy (TECA-LBO). STUDY DESIGN: Randomized blinded clinical study. ANIMALS: A group of 20 client-owned dogs undergoing TECA-LBO. METHODS: Intravenous (IV) administration of lidocaine (3 mg kg-1) and ketamine (0.6 mg kg-1) with fentanyl (5.4 µg kg-1; n = 10; FLK group) or sufentanil (0.72 µg kg-1; n = 10; SLK group) was immediately followed by the corresponding constant rate infusion (CRI) (lidocaine 3 mg kg-1 hour-1; ketamine 0.6 mg kg-1 hour-1; either fentanyl 5.4 µg kg-1 hour-1 or sufentanil 0.72 µg kg-1 hour-1). Anaesthesia was induced with propofol 3-5 mg kg-1 IV and was maintained with isoflurane. End-tidal isoflurane concentration (Fe'Iso) was decreased in 0.2% steps every 15 minutes until spontaneous movements were observed (treated with propofol 1 mg kg-1 IV) or an increase of > 30% in heart rate or mean arterial pressure from baseline occurred (treated with rescue fentanyl or sufentanil). Quality of recovery and pain were assessed at extubation using the short-form Glasgow Composite Pain Scale (SF-GCPS), Colorado State University Canine Acute Pain scale (CSU-CAP), and visual analogue scale (VAS). Data were analysed with analysis of variance, t tests, Fisher test and Spearman coefficient (p < 0.05). RESULTS: Fe'Iso decreased significantly in SLK group (45%; p = 0.0006) but not in FLK (15%; p = 0.1135) (p = 0.0136). SLK group had lower scores for recovery quality (p = 0.0204), SF-GCPS (p = 0.0071) and CSU-CAP (p = 0.0273) than FLK at extubation. Intraoperative rescue analgesia and VAS were not significantly different between groups. CONCLUSIONS AND CLINICAL RELEVANCE: Compared with FLK infusion, CRI of SLK at these doses decreased isoflurane requirements, decreased pain scores and improved recovery quality at extubation in dogs undergoing TECA-LBO.
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Técnicas de Ablación/veterinaria , Anestesia/veterinaria , Anestésicos Intravenosos/farmacología , Enfermedades de los Perros/cirugía , Conducto Auditivo Externo/cirugía , Osteotomía/veterinaria , Anestésicos Disociativos/administración & dosificación , Anestésicos Disociativos/farmacología , Anestésicos Intravenosos/administración & dosificación , Anestésicos Locales/administración & dosificación , Anestésicos Locales/farmacología , Animales , Perros , Fentanilo/administración & dosificación , Fentanilo/farmacología , Ketamina/administración & dosificación , Ketamina/farmacología , Lidocaína/administración & dosificación , Lidocaína/farmacología , Sufentanilo/administración & dosificación , Sufentanilo/farmacologíaRESUMEN
OBJECTIVE: To evaluate the long-term efficacy of the transobturator vaginal tape inside out (TVT-O) in female dogs with urethral sphincter mechanism incompetence (USMI). STUDY DESIGN: Retrospective study. ANIMALS: Incontinent spayed female dogs (n = 12). METHODS: TVT-O tape was inserted in 12 incontinent bitches diagnosed with USMI. Follow-up information was evaluated by a telephone questionnaire, and a continence score was attributed. RESULTS: One year after surgery, 7 of 12 (58%) dogs were completely continent. Two dogs were removed from the long-term analysis (1 dead and 1 lost). At a median follow-up time of 85 months (range, 28-95), 4 of 10 dogs were completely continent without medical treatment. Incontinence recurred in 6 dogs at a median time of 2 months after surgery (range 1-20). Among these 6 dogs, 4 regained continence, and 2 had sporadic episodes of incontinence with additional medical treatment. No postoperative complications were encountered. CONCLUSION: TVT-O alone was successful in maintaining long-term continence in 40% of the dogs. Additional postoperative medical treatment was effective in restoring continence in another 40% of the dogs. CLINICAL SIGNIFICANCE: TVT-O provides an alternative treatment of USMI in female dogs that is safe and less invasive than standard surgical techniques.
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Enfermedades de los Perros/cirugía , Complicaciones Posoperatorias/veterinaria , Cabestrillo Suburetral/veterinaria , Enfermedades Uretrales/veterinaria , Incontinencia Urinaria/veterinaria , Procedimientos Quirúrgicos Urológicos/veterinaria , Animales , Enfermedades de los Perros/fisiopatología , Perros , Femenino , Cabestrillo Suburetral/estadística & datos numéricos , Resultado del Tratamiento , Uretra/fisiopatología , Uretra/cirugía , Enfermedades Uretrales/cirugía , Incontinencia Urinaria/cirugía , Urodinámica , Procedimientos Quirúrgicos Urológicos/instrumentación , Procedimientos Quirúrgicos Urológicos/métodosRESUMEN
OBJECTIVE: To determine the influence of manipulations aimed at increasing the transdiaphragmatic pressure gradient on the gastro-esophageal junction (GEJ) of dogs with brachycephalic airway obstructive syndrome (BAOS), and to identify the manipulation that most improves the detection of GEJ abnormalities and sliding hiatal hernia (SHH) in dogs with BAOS. STUDY DESIGN: In vivo experimental pilot study and prospective clinical study. ANIMALS: Five purpose-bred Beagles and 20 dogs diagnosed with BAOS. METHODS: Respiratory and digestive clinical signs as well as respiratory and GEJ abnormalities were scored. The presence of SHH was investigated using radiography and endoscopy in standard conditions. Endoscopic investigation was repeated after manipulations including manual pressure on the cranial abdomen (MP), Trendelenburg position (30°), or temporary complete endotracheal tube obstruction (ETO). RESULTS: No SHH was detected in any normal dog under any condition. Sixty-five percent of dogs with BAOS presented with digestive clinical signs, including vomiting and/or regurgitation. SHH was observed in only one dog via radiography and was not detected via endoscopy. Manipulations during endoscopy influenced GEJ abnormalities and allowed the detection of SHH in 2 (30°), 4 (ETO), and 5 (MP) dogs, respectively. Digestive clinical signs correlated with GEJ abnormalities observed only in dogs with ETO (P = .02). CONCLUSION: Manipulations aimed at increasing the transdiaphragmatic pressure gradient during endoscopy in BAOS dogs allowed the detection of GEJ abnormalities and SHH that were not detected under standard conditions. Although MP allowed detection of SHH in more dogs than ETO, scores under MP did not correlate with digestive clinical signs. Therefore, ETO may be more accurate manipulation for the detection of GEJ abnormalities in BAOS dogs.
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Obstrucción de las Vías Aéreas/veterinaria , Craneosinostosis/veterinaria , Enfermedades de los Perros/diagnóstico , Hernia Hiatal/veterinaria , Animales , Enfermedades de los Perros/diagnóstico por imagen , Perros , Femenino , Hernia Hiatal/diagnóstico , Hernia Hiatal/diagnóstico por imagen , Masculino , Linaje , Proyectos Piloto , Estudios ProspectivosRESUMEN
OBJECTIVE: To determine outcomes after surgical correction of ectopic ureters (EU) and identify prognostic factors for long-term continence. STUDY DESIGN: Retrospective study. ANIMALS: Forty-seven dogs (36 females and 11 males). METHODS: Medical records (1999-2016) of dogs with surgical correction of EU were reviewed. A continence score (1 = incontinent, 2 = sporadic incontinence, 3 = continent) was attributed preoperatively, at discharge, 1 month postoperatively, and at long-term evaluation. RESULTS: Twenty-eight dogs had unilateral and 19 dogs had bilateral EU (57 intramural and 9 extramural). Nineteen dogs had a pelvic bladder. Neoureterostomy with dissection (n = 50), ureteroneocystotomy (n = 9), or nephroureterectomy (n = 7) were performed. Thirty-three dogs were neutered: 32 before or during the surgery and 1 after surgery. Colposuspension was performed during surgical correction in 15 dogs. Adjuvant medical treatment improved postoperative continence scores. Median continence scores were greater at discharge (3), at 1 month postoperatively (3), and at long-term evaluation (3) than before surgery (1). At long-term evaluation (mean 46.1 months), a score of 1 was observed in 19%, a score of 2 in 7%, and a score of 3 in 74% of the dogs. CONCLUSION: Overall, good (score 2) to excellent (score 3) long-term outcome was achieved in 81% of dogs. Long-term continence was improved with medical treatment and neutering was not associated with an increased risk of recurrence of incontinence in this population of dogs.
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Enfermedades de los Perros/cirugía , Uréter/anomalías , Incontinencia Urinaria/veterinaria , Procedimientos Quirúrgicos Urológicos/veterinaria , Animales , Perros , Femenino , Masculino , Estudios Retrospectivos , Resultado del Tratamiento , Uréter/cirugía , Incontinencia Urinaria/cirugíaRESUMEN
The objective of this retrospective study was to determine the efficacy of a single daily oral dose of phenylpropanolamine (PPA) in the treatment of urethral sphincter mechanism incompetence (USMI) in bitches. Nine bitches diagnosed with USMI were treated with a single daily dose [1.5 mg/kg body weight (BW)] of PPA for at least 1 month. Urethral pressure profiles (UPP) were performed in 7 dogs before treatment and repeated in 4 of them after treatment. Treatment with PPA resulted in long-term continence in 8/9 bitches. One dog did not respond to PPA and was treated surgically later. Recheck UPPs showed a significant increase in maximal urethral closure pressure in the 4 bitches after treatment with PPA compared to before treatment. In conclusion, long-term continence can be achieved in bitches affected with USMI after administration of a single daily dose of PPA (1.5 mg/kg BW).
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Agonistas alfa-Adrenérgicos/uso terapéutico , Enfermedades de los Perros/tratamiento farmacológico , Fenilpropanolamina/uso terapéutico , Incontinencia Urinaria/veterinaria , Agonistas alfa-Adrenérgicos/administración & dosificación , Animales , Perros , Esquema de Medicación/veterinaria , Femenino , Fenilpropanolamina/administración & dosificación , Estudios Retrospectivos , Resultado del Tratamiento , Incontinencia Urinaria/tratamiento farmacológicoRESUMEN
OBJECTIVES: (1) To describe a surgical technique adapted from the "transobturator vaginal tape inside-out" (TVT-O) used in women and to define the trajectory of the tape on canine cadavers, and (2) to determine the urodynamic and morphological effects of the TVT-O in continent bitches. STUDY DESIGN: Cadaveric and experimental in vivo study. ANIMALS: Fresh female canine cadavers (n=12) and spayed female Beagle dogs (2). METHODS: (1) TVT-O was inserted in 12 cadavers. Dissection was performed and distances between the tape and neighboring structures were recorded. (2) TVT-O was inserted in 2 continent female Beagle dogs. Urethral pressure profilometry and vaginourethrograms were performed preoperatively, immediately after surgery, and 2, 4, and 6 months postoperatively. Histopathology was performed 6 months after surgery. RESULTS: (1) TVT-O tape was consistently located in a perineal space before entering the obturator foramina and was located at a safe distance from major neurovascular structures including the femoral vessels and obturator nerve. (2) TVT-O was performed without any surgical or postoperative complications in 2 continent bitches. Histopathologic examination of the tissues surrounding the tape revealed a mild fibroblastic proliferation with a mild to minimal lymphoplasmacytic inflammatory infiltration. CONCLUSIONS: TVT-O is a feasible and accurate procedure that can be performed in continent bitches with a low risk of complications.
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Enfermedades de los Perros/cirugía , Cabestrillo Suburetral/veterinaria , Uretra/fisiopatología , Trastornos Urinarios/veterinaria , Procedimientos Quirúrgicos Urológicos/veterinaria , Animales , Cadáver , Enfermedades de los Perros/fisiopatología , Perros , Femenino , Complicaciones Posoperatorias/veterinaria , Resultado del Tratamiento , Uretra/cirugía , Trastornos Urinarios/fisiopatología , Trastornos Urinarios/cirugía , Urodinámica , Procedimientos Quirúrgicos Urológicos/instrumentación , Procedimientos Quirúrgicos Urológicos/métodosRESUMEN
OBJECTIVES: To evaluate the clinical efficacy of the transobturator vaginal tape inside-out (TVT-O) in incontinent female dogs affected with urethral sphincter mechanism incompetence (USMI) and to determine its urodynamic and morphologic effects. STUDY DESIGN: Case series. ANIMALS: Incontinent spayed female dogs (n=7). METHODS: TVT-O tape was inserted in 7 incontinent female dogs diagnosed with USMI. Urethral pressure profilometry (UPP) and vaginourethrograms were performed preoperatively, and 1 and 3 months postoperatively. Clinical efficacy of the technique was evaluated and complications reported. Follow-up information was evaluated by a telephone questionnaire. RESULTS: All dogs were continent immediately after the procedure. Incontinence recurred 2 months after surgery in 1 dog and was treated by phenylpropanolamine administration. At mean follow-up time of 11.3 months, 6 of 7 dogs were continent. An iatrogenic urethral tear occurred intraoperatively in 1 dog. No postoperative complications were encountered. The postoperative UPPs showed significantly increased maximal urethral closure pressure and integrated pressure. Postoperative vaginourethrograms were unremarkable. The surgical procedure did not modify the location of the urinary bladder neck in dogs with a "pelvic urinary bladder" preoperatively. CONCLUSIONS: TVT-O was efficient in maintaining short term continence in 6 of 7 dogs affected with USMI.
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Enfermedades de los Perros/cirugía , Cabestrillo Suburetral/veterinaria , Enfermedades Uretrales/veterinaria , Incontinencia Urinaria/veterinaria , Procedimientos Quirúrgicos Urológicos/veterinaria , Animales , Enfermedades de los Perros/fisiopatología , Perros , Femenino , Complicaciones Posoperatorias/veterinaria , Resultado del Tratamiento , Uretra/fisiopatología , Uretra/cirugía , Enfermedades Uretrales/cirugía , Incontinencia Urinaria/cirugía , Urodinámica , Procedimientos Quirúrgicos Urológicos/instrumentación , Procedimientos Quirúrgicos Urológicos/métodosRESUMEN
Various pathologies can affect the bladder and/or urethral contractility causing signs of urinary incontinence. In this second part of a three-part review, the pathophysiology of impaired urethral contractility (including urethral hyper- and hypotonicity) in the bitch and in women is discussed. Urethral sphincter mechanism incompetence (USMI) is the most common form of acquired urinary incontinence in bitches and is characterized by a decreased urethral tone. The pathophysiology and current recommended medical treatment options for USMI and cases of modified urethral tonicity due to a neurological disorder or functional outlet obstruction are discussed. Treatment options in human medicine in cases of impaired urethral contractility are described.
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Enfermedades de los Perros/fisiopatología , Uretra/fisiopatología , Incontinencia Urinaria/veterinaria , Animales , Enfermedades de los Perros/terapia , Perros , Femenino , Humanos , Contracción Muscular , Enfermedades Uretrales/fisiopatología , Enfermedades Uretrales/terapia , Incontinencia Urinaria/fisiopatología , Incontinencia Urinaria/terapiaRESUMEN
OBJECTIVE: To describe outcome of treatment with propofol and phenobarbital for status epilepticus (SE) after portosystemic shunt (PSS) attenuation. CASE OR SERIES SUMMARY: Three dogs without preceding seizure activity, were diagnosed with a single extrahepatic PSS. Following standard preoperative medical therapy, an ameroid constrictor was placed surgically. Recovery was uneventful until spontaneous SE developed 46-96 hours after surgery. After unsuccessful seizure control with benzodiazepines, dogs were treated with a bolus of propofol followed by a propofol constant rate infusion. Phenobarbital was concurrently administered and supportive care was optimized. All dogs recovered uneventfully over the next 7-9 days. Over the following months phenobarbital was slowly tapered. All dogs have been free from antiepileptic drugs for several months, without recurrence of neurologic signs. NEW OR UNIQUE INFORMATION PROVIDED: In this case series, we describe the treatment of 3 dogs with propofol and phenobarbital for refractory SE following attenuation of a single congenital PSS. After weaning of the propofol constant rate infusion, and tapering and discontinuation of phenobarbital over the following months, all dogs experienced a complete recovery. This study provides evidence that use of propofol in combination with phenobarbital may be efficacious for management of SE in dogs after PSS surgery.
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Anticonvulsivantes/uso terapéutico , Enfermedades de los Perros/etiología , Hepatopatías/veterinaria , Fenobarbital/uso terapéutico , Sistema Porta/anomalías , Complicaciones Posoperatorias/veterinaria , Propofol/uso terapéutico , Estado Epiléptico/veterinaria , Animales , Enfermedades de los Perros/congénito , Enfermedades de los Perros/cirugía , Perros , Femenino , Masculino , Sistema Porta/cirugía , Complicaciones Posoperatorias/tratamiento farmacológico , Estudios Retrospectivos , Estado Epiléptico/tratamiento farmacológicoRESUMEN
The clinical features of brachycephalic airway obstructive disease in 11 brachycephalic dogs are described in this study. The respiratory strategy was assessed before (n=11) and after (n=6) surgery using barometric whole-body plethysmography (BWBP), with the relationship between BWBP variables and the severity of the clinical signs assessed by the use of a respiratory score based on clinical, radiographic and endoscopic findings. Partial collapse of the left main bronchus was a common finding not previously described as part of the brachycephalic airway obstructive disease syndrome. Epiglottic cysts, laryngeal granulomas and nasopharyngeal turbinates in English Bulldogs were other previously unreported findings. No significant correlation between the respiratory score and any of the BWBP variables was detected. Compared to healthy dogs, brachycephalic dogs had a significantly lower Te/Ti ratio (expiratory time over inspiratory time), peak inspiratory flow (PIF) per kg bodyweight (BW), significantly higher peak expiratory flow (PEF) per kgBW, PEF/PIF, and enhanced pause. These variations are compatible with upper airway obstructions primarily in the extrathoracic airways. Following surgery, a significant decrease in PEF/PIF was detected. The study showed that BWBP could be used to characterise the respiratory strategy in brachycephalic dogs before and after surgery.
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Obstrucción de las Vías Aéreas/veterinaria , Enfermedades de los Perros/diagnóstico , Pletismografía Total/veterinaria , Pruebas de Función Respiratoria/veterinaria , Obstrucción de las Vías Aéreas/diagnóstico , Obstrucción de las Vías Aéreas/patología , Obstrucción de las Vías Aéreas/cirugía , Resistencia de las Vías Respiratorias/fisiología , Animales , Broncoscopía/veterinaria , Enfermedades de los Perros/patología , Enfermedades de los Perros/cirugía , Perros , Femenino , Masculino , Pletismografía Total/métodos , Pletismografía Total/normas , Pruebas de Función Respiratoria/métodos , Pruebas de Función Respiratoria/normas , Índice de Severidad de la Enfermedad , Síndrome , Resultado del TratamientoRESUMEN
Micturition disorders are commonly encountered in veterinary medicine and can be divided into two main categories, namely, urinary incontinence and urinary retention. Various pathologies can affect the bladder and/or urethral contractility causing symptoms of urinary incontinence. In this first part of a three-part review, the different causes of urinary incontinence, the physiology of the lower urinary tract and impaired bladder contractility are reviewed. Since urinary incontinence due to overactive bladder syndrome or detrusor atony is described in both dogs and humans, the different therapeutic targets in the treatment of impaired bladder contractility in human and veterinary medicine are discussed.
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Enfermedades de los Perros/fisiopatología , Vejiga Urinaria/fisiopatología , Incontinencia Urinaria/veterinaria , Animales , Enfermedades de los Perros/terapia , Perros , Femenino , Humanos , Contracción Muscular , Vejiga Urinaria Hiperactiva/terapia , Incontinencia Urinaria/fisiopatología , Incontinencia Urinaria/terapiaRESUMEN
Urethral sphincter mechanism incompetence (USMI) is the most common cause of urinary incontinence in dogs. Surgery may be recommended if the animal does not respond to medical treatment or becomes refractory. In this third part of a three-part review, surgical options for the treatment of USMI are described. Colposuspension is the most frequently described procedure and offers a fair prognosis, with about 50% of the dogs being continent after surgery and most of the reminder being improved or more responsive to medical treatment. Urethropexy offers a similar success rate, but with a higher rate of complications. Endoscopic injection of collagen is an attractive technique due to its minimally invasive nature and low risk of adverse effects. Initial results may however deteriorate with time. Other procedures have been reported, but involve a low number of cases and have resulted in variable success rates. In women, stress urinary incontinence is mainly treated by minimally invasive procedures involving vaginal placement of sub-urethral slings.