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1.
Personal Ment Health ; 17(2): 135-146, 2023 05.
Artículo en Inglés | MEDLINE | ID: mdl-36089289

RESUMEN

Emerging dimensional models of personality disorders such as the Alternative DSM-5 Model for Personality Disorders (AMPD) provide new opportunities to explore the associations between personality pathology and harmful interpersonal behaviours such as stalking perpetration. Two goals are pursued by this study: (a) To document associations between stalking, level of personality pathology, and pathological personality domains/facets; and (b) to determine the relative importance of maladaptive personality facets in the statistical prediction of stalking. Data from 1489 young adults (18-30 years old) from a community sample were analysed. Moderate positive significant correlations were found between stalking, level of personality pathology, and maladaptive personality domains. A clear gradient of severity of stalking behaviours was found across five severity degrees of personality pathology. Dominance analyses revealed that Deceitfulness was the most dominant statistical predictor in women. Unusual Beliefs and Experiences, a facet from the Psychoticism domain, made an important contribution in the prediction of stalking in men only. Impulsivity was a key predictor in both genders but more markedly in men. Results suggest that the AMPD represents a useful framework to study stalking perpetration. Identification of key personality predictors might prove relevant for identifying risk factors, underlying motives, and treatment targets for stalking perpetrators.


Asunto(s)
Acecho , Adulto Joven , Humanos , Masculino , Femenino , Adolescente , Adulto , Trastornos de la Personalidad/diagnóstico , Personalidad , Conducta Impulsiva , Manual Diagnóstico y Estadístico de los Trastornos Mentales , Inventario de Personalidad
2.
J Biol Rhythms ; 37(6): 655-672, 2022 12.
Artículo en Inglés | MEDLINE | ID: mdl-36168739

RESUMEN

DTNBP1 is a gene associated with schizophrenia. Postmortem studies found a reduced expression of DTNBP1 in regions associated with schizophrenia in patients' brains. Sandy (Sdy) mice have a loss-of-function mutation in Dtnbp1 gene, resulting in behavioral deficits and brain changes similar to those seen in patients with schizophrenia. We previously showed that exposing adult Sdy mice to circadian disruption led to an exacerbation of schizophrenia-relevant behaviors. Here we asked whether the interaction between this genetic risk factor and circadian disruption occurs during adolescence, a period when environmental insults can promote schizophrenia symptoms, and whether sex affects this interaction. Starting at postnatal day 21, wild-type (WT) and Sdy males and females were housed for 4 weeks either in a 12 h light:12 h dark (LD 12:12) cycle or under chronic jetlag (CJL). Then, after 2 weeks in LD 12:12, behavioral assessments were conducted, including elevated plus maze (EPM), novel object recognition (NOR), social interaction, and prepulse inhibition (PPI) of acoustic startle. NOR and social novelty tests showed that, surprisingly, CJL during adolescence had opposite effects on WT and Sdy males, that is, behavioral deficits in WT males while rescuing preexisting deficits in Sdy mice. CJL led to decreased sociability in WT and Sdy mice while decreasing PPI only in females. Sdy mice showed decreased anxiety-like behavior compared with wild-type (WT), which was further accentuated by CJL in males. Thus, circadian disruption during adolescence, on its own or in association with Dtnbp1 mutation, can influence cognition, sociability, sensorimotor gating, and anxiety-like behaviors in a sex-dependent manner.


Asunto(s)
Esquizofrenia , Masculino , Femenino , Ratones , Animales , Esquizofrenia/genética , Disbindina , Ritmo Circadiano/genética , Conducta Animal/fisiología , Factores de Riesgo
3.
Front Neurosci ; 16: 855154, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35495037

RESUMEN

Mistimed exposure to light has been demonstrated to negatively affect multiple aspects of physiology and behavior. Here we analyzed the effects of chronic exposure to abnormal lighting conditions in mice. We exposed mice for 1 year to either: a standard light/dark cycle, a "light-pollution" condition in which low levels of light were present in the dark phase of the circadian cycle (dim light at night, DLAN), or altered light cycles in which the length of the weekday and weekend light phase differed by 6 h ("social jetlag"). Mice exhibited several circadian activity phenotypes, as well as changes in motor function, associated particularly with the DLAN condition. Our data suggest that these phenotypes might be due to changes outside the core clock. Dendritic spine changes in other brain regions raise the possibility that these phenotypes are mediated by changes in neuronal coordination outside of the clock. Given the prevalence of artificial light exposure in the modern world, further work is required to establish whether these negative effects are observed in humans as well.

4.
J Interpers Violence ; 37(21-22): NP19420-NP19446, 2022 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-34467790

RESUMEN

Stalking and obsessive relational intrusions both refer to a pervasive and unwanted pattern of pursuit behaviors, the former being a criminal offense evoking fear and a sense of menace in the victim, while the latter may be perceived as annoying or otherwise undesirable, but not necessarily fear inducing. While the individual and societal costs of stalking and obsessive relational intrusion are increasingly recognized, research regarding these behaviors and their consequences has been limited by measurement issues, as most studies have relied on questionnaires and checklists based on very limited validation data. The goal of the present study is to report on the development and validation of the Stalking and Obsessive Relational Intrusions Questionnaire (SORI-Q), a 28-item self-report questionnaire designed to probe for perpetration of stalking-like behaviors. Young adults (age 18-30 years) from a community sample (N = 1,804; 82.6% women) were recruited online. They completed the SORI-Q, along with measures of dark personality traits, insecure attachment dimensions, and intimate partner violence. Overall, the SORI-Q displayed sound psychometric properties. Exploratory and Confirmatory Factor Analysis yielded a two-factor solution (Hyper-intimacy and Domineering control) with adequate to good fit indices. The total scale and the two factor scores showed high internal consistency (above 0.70 for all indices). A number of gender differences were observed at total-, factor-, and item-level, the most outstanding being that women had a higher score on the total SORI-Q score, and on the Domineering control factor and most of its items. The questionnaire showed conceptually meaningful positive correlations with dark personality traits, attachment anxiety, and intimate partner violence. Dominance analysis revealed that attachment anxiety and Machiavellianism were the strongest statistical predictors of SORI-Q scores. The SORI-Q should be seen as a promising new measure of stalking-like and ORI behaviors in young adults from community settings.


Asunto(s)
Violencia de Pareja , Acecho , Adolescente , Adulto , Análisis Factorial , Femenino , Humanos , Masculino , Conducta Obsesiva , Parejas Sexuales , Encuestas y Cuestionarios , Adulto Joven
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