[2-R-mercapto-1, 3, 4-thyadiazol derivates having biological activity. Note I]. / Derivati ai 2-R-5-mercapto-1, 3, 4-tiadiazolului, cu activitate biologica. Nota I.

The importance of 1,3,4-thyadiazol nucleus is illustrated by the fact that it enters the structure of many compounds having different biological activities. In this paper the results of some investigations for obtaining new derivates of 1,3,4-thydiazol 2,5 distributed are presented. Based upon the presented diagram 13 2-R-5-mercapto-1,3,4-thyadiazols, analysed both physico-chemically and biologically were synthetized.

[Investigations for obtaining compounds with potential antiinflammatory action, carboxymethylic ethers of some oximes]. / Cercetari privind: obtinerea de compusi cu actiune antiinflamatoare potentiala, eteri carboximetalici ai unor oxime.

In this paper the synthesis of 5 etheric derivates of some aromatic oxymes: p-metoxy-benz-(sin)-aldoxyme, p-chlorine-benz-(sin)-aldoxyme, sin-piperonal-oxyme, 2,4-di- chlorinebenzaldoxyme and 3,4-dichlor-benzaldoxyme were described. In view of a subsequent study on the antiinflammatory action a simple method for obtaining these compounds based on the reaction between the sodium salt of the monochloracetic acid and the sodium derivates of the corresponding oxymes. The structure of the newly obtained products was confirmed by the elementary quantitative chemical analysis and the spectral analysis in IR.