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1.
Curr Pharm Teach Learn ; 16(1): 64-68, 2024 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-38158324

RESUMEN

BACKGROUND AND PURPOSE: Engaging in therapeutic lifestyle changes (TLC) such as healthy eating and physical activity can help prevent or manage various conditions. This study's purpose is to describe a TLC elective course and examine its impact on student knowledge, empathy, and perceptions of confidence with lifestyle modifications counseling. EDUCATIONAL ACTIVITY AND SETTING: An elective was developed to increase student pharmacists' knowledge and confidence in educating patients about lifestyle modifications. Activities were intended to foster student empathy. A questionnaire, given at course initiation and conclusion, incorporated a knowledge quiz and Kiersma-Chen Empathy Scale (KCES). Student perceptions of confidence were assessed at course conclusion. FINDINGS: Knowledge significantly increased (P < .001) from 54.1% at course initiation to 75% at course conclusion when comparing average quiz scores. Average KCES scores (out of 105 points) were 84.9 (n = 26) and 86 (n = 22) at course initiation and conclusion, respectively, showing no significant change in empathy scores (P = .01). For each course topic, most students reported being somewhat or very confident in their TLC counseling abilities at course conclusion. SUMMARY: An elective course significantly improved TLC knowledge and perceived confidence regarding TLC counseling was high at course conclusion. Although there was no significant change in KCES scores, including dedicated TLC instruction in pharmacy curricula can help students build knowledge and confidence in TLC counseling in preparation for pharmacy practice.


Asunto(s)
Educación en Farmacia , Estudiantes de Farmacia , Humanos , Empatía , Estilo de Vida , Curriculum , Estudiantes de Farmacia/psicología
2.
AIDS Patient Care STDS ; 37(9): 447-457, 2023 09.
Artículo en Inglés | MEDLINE | ID: mdl-37713289

RESUMEN

To test the hypothesis that implementation of a multicomponent, educational HIV pre-exposure prophylaxis (PrEP) intervention to promote universal PrEP services for cisgender women (subsequently "women") in sexual and reproductive health centers would improve the proportion of women screened, offered, and prescribed PrEP, we implemented a multicomponent, educational intervention in a Washington D.C. Department of Health-sponsored sexual health clinic. The clinic serves a patient population with high-potential exposure to HIV. The intervention included clinic-wide PrEP trainings, an electronic health record prompt for PrEP counseling by providers, and educational videos in the waiting room. We collected preimplementation data from March 22, 2018 to July 4, 2018, including 331 clinical encounters for 329 women. Between July 5, 2018 and July 1, 2019, there were 1733 clinical encounters for 1720 HIV-negative women. We used mixed methods to systematically assess intervention implementation using the Reach Effectiveness Adoption Implementation Maintenance framework. Additionally, we assessed the interventions' acceptability and feasibility among providers through semistructured interviews. The proportion of women screened by providers for PrEP (5.6% preimplementation to a mean of 89.2% of women during the implementation period, p < 0.01), offered (6.2 to 69.8%, p < 0.01), and prescribed PrEP (2.6 to 8.1%, p < 0.01) by providers increased significantly in the implementation period. Providers and clinic staff found the intervention both highly feasible and acceptable and demonstrated increased knowledge of PrEP and HIV prevention associated with the clinic-wide trainings. Our results demonstrate the effectiveness of a low-cost educational intervention to increase provision of integrated PrEP services in an urban sexual health clinic serving women with high-potential exposure to HIV. ClinicalTrials.gov ID NCT03705663.


Asunto(s)
Infecciones por VIH , Profilaxis Pre-Exposición , Salud Sexual , Humanos , Infecciones por VIH/prevención & control , Instituciones de Atención Ambulatoria , Escolaridad
3.
Womens Health Issues ; 33(5): 541-550, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-37479630

RESUMEN

OBJECTIVE: Our objective was to identify the individual, interpersonal, community, health-system, and structural factors that influence HIV pre-exposure prophylaxis (PrEP) initiation among cisgender women seeking sexual and reproductive health care in a high HIV prevalence community to inform future clinic-based PrEP interventions. METHODS: We collected anonymous, tablet-based questionnaires from a convenience sample of cisgender women in family planning and sexual health clinics in the District of Columbia. The survey used the lens of the socio-ecological model to measure individual, interpersonal, community, institutional, and structural factors surrounding intention to initiate PrEP. The survey queried demographics, behavioral exposure to HIV, perceived risk of HIV acquisition, a priori awareness of PrEP, intention to initiate PrEP, and factors influencing intention to initiate PrEP. RESULTS: A total of 1437 cisgender women completed the survey. By socio-ecological level, intention to initiate PrEP was associated with positive attitudes toward PrEP (odds ratio [OR], 1.56; 95% confidence interval [CI], 1.13-2.15) and higher self-efficacy (OR, 1.32; 95% CI, 1.02-1.72) on the individual level, perceived future utilization of PrEP among peers and low fear of shame/stigma (OR, 1.65; 95% CI, 1.33-2.04) on the community level, and having discussed PrEP with a provider (OR. 2.39; 95% CI, 1.20-4.75) on the institutional level. CONCLUSION: Our findings highlight the importance of multilevel, clinic-based interventions for cisgender women, which promote sex-positive and preventive PrEP messaging, peer navigation to destigmatize PrEP, and education and support for women's health medical providers in the provision of PrEP services for cisgender women.


Asunto(s)
Infecciones por VIH , Profilaxis Pre-Exposición , Humanos , Femenino , Intención , Infecciones por VIH/epidemiología , Infecciones por VIH/prevención & control , Infecciones por VIH/tratamiento farmacológico , Prevalencia , Conducta Sexual
4.
Health Commun ; 38(14): 3264-3275, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-36398676

RESUMEN

Pre-exposure prophylaxis (PrEP) is a highly effective daily pill that decreases the likelihood of HIV acquisition by up to 92% among individuals at risk for HIV. PrEP can be discretely used, autonomously controlled, and in place at the time of risk exposure, making it an especially promising method for HIV prevention for cisgender women (CGW). But, PrEP is underutilized by CGW relative to the demonstrable need. We apply the Integrative Model of Behavioral Prediction to identify the critical psychosocial factors that shape CGW's intentions to use PrEP and their relevant underlying beliefs. We surveyed (N = 294) community- and clinic-recruited PrEP eligible CGW to understand the relative importance of attitudes, norms, and efficacy in shaping PrEP intentions. We utilized structural equation modeling to identify the relevant paths. We inspected the summary statistics in relation to three message three selection criteria. We identified beliefs that demonstrated (1) an association with intention, (2) substantial room to move the population, (3) practicality as a target for change through communication intervention. Results show that PrEP awareness was low. When women learned about PrEP, they voiced positive intentions to use it. There were significant and positive direct effects of SE (0.316***), attitudes (0.201**), and subjective norms (0.249***) on intention to initiate PrEP. We illustrate the strategic identification of beliefs within the relevant paths using the 3 belief selection criteria. We also discuss implications for social and structural communication interventions to support women's HIV prevention.


Asunto(s)
Infecciones por VIH , Profilaxis Pre-Exposición , Humanos , Femenino , Infecciones por VIH/prevención & control , Intención , Encuestas y Cuestionarios , Profilaxis Pre-Exposición/métodos , Comunicación
5.
Public Health Rep ; 138(5): 763-770, 2023.
Artículo en Inglés | MEDLINE | ID: mdl-36346165

RESUMEN

OBJECTIVE: Preexposure prophylaxis (PrEP) is recommended for people at risk of acquiring HIV. We assessed billable costs associated with PrEP delivery at community health centers. METHODS: The Sustainable Health Center Implementation PrEP Pilot (SHIPP) study is an observational cohort of people receiving daily oral PrEP at participating federally qualified health centers and other community health centers. We assessed health care utilization and billable costs of providing PrEP at 2 health centers, 1 in Chicago, Illinois, and 1 in Washington, DC, from 2014 to 2018. The health centers followed the clinical practice guidelines for PrEP provision, including regular visits with health care providers and ongoing laboratory monitoring. Using clinic billing records and Current Procedural Terminology (CPT) coding, we retrospectively extracted data on the frequency and costs (in 2017 US dollars) of PrEP clinic visits and laboratory screening, for each patient, for 12 months since first PrEP prescription. RESULTS: The average annual number of PrEP clinic visits and associated laboratory screens per patient was 5.1 visits and 25.2 screens in Chicago (n = 482 patients) and 5.4 visits and 24.8 screens in Washington, DC (n = 56 patients). The average annual PrEP billable cost per patient was $583 for clinic visits and $1070 for laboratory screens in Chicago and $923 for clinic visits and $1018 for laboratory screens in Washington, DC. The average annual total cost per patient was $1653 (95% CI, $1639-$1668) in Chicago and $1941 (95% CI, $1811-$2071) in Washington, DC. CONCLUSIONS: Our analysis, which provides PrEP billable cost estimates based on empirical data, may help inform health care providers who are considering implementing this HIV prevention strategy.

6.
Arch Sex Behav ; 51(5): 2613-2624, 2022 07.
Artículo en Inglés | MEDLINE | ID: mdl-35622077

RESUMEN

Pre-exposure prophylaxis (PrEP) for HIV prevention is underutilized by cisgender women at risk for HIV in the USA. Published research on PrEP initiation among cisgender women at risk for HIV focuses on identifying barriers and facilitators associated with intention to initiate, but few apply a behavioral theoretical lens to understand the relative importance of these diverse factors. This study provides a theoretically grounded view of the relative importance of factors associated with intention to initiate PrEP. We conducted an anonymous, cross-sectional survey of 1437 cisgender women seeking care at family planning and sexual health clinics to evaluate hypothesized barriers and facilitators of PrEP initiation. We categorized cisgender women with ≥ 3 behavioral risk-factors as "high-risk" for HIV acquisition; 26.9% (N = 387) met high-risk criterion. Among cisgender women in the high-risk sample, the majority were Black and single. Perceived risk of HIV acquisition was low and 13.7% reported intention to initiate PrEP. Positive attitudes toward PrEP, self-efficacy, perceived support from medical providers and social networks, and prior discussion about PrEP with medical providers were associated with intention to initiate PrEP; stigma was negatively associated. Background characteristics (other than age), risk factors for HIV acquisition, prior awareness of PrEP, and perceived risk of HIV were not associated with uptake intention. These findings support interventions that center on the role of providers in the provision of PrEP and on social networks in destigmatization of PrEP use.


Asunto(s)
Infecciones por VIH , Profilaxis Pre-Exposición , Estudios Transversales , District of Columbia , Femenino , Infecciones por VIH/prevención & control , Conocimientos, Actitudes y Práctica en Salud , Humanos , Intención
7.
Transplant Proc ; 54(3): 645-651, 2022 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-35256201

RESUMEN

BACKGROUND: The aim of this study was to compare single-dose rabbit anti-thymocyte globulin (rATG) with a divided dose in kidney transplant recipients within a majority Black patient population. METHODS: We analyzed the outcomes before and after a change in protocol from divided-dose (1.5 mg/kg/day over 4 days) to single-dose (6 mg/kg over 24 hours) rATG in a retrospective cohort study. All patients who received rATG for kidney transplant induction between December 2015 and July 2018 were included. RESULTS: A total of 197 patients (n = 98 in the divided-dose group, n = 99 in the single-dose group) received rATG. There was no difference in time to rejection at 1 year (P = .82) or incidence of rejection (P = .80). There was also no difference in delayed graft function, serum creatinine, or survival at 1 year. Patients in the single-dose group were more likely to leave the hospital by postoperative day 3 (12% vs 2%, P = .006). The cytomegalovirus infection rate was higher in the single-dose group (P = .031). CONCLUSIONS: Use of a single-dose rATG regimen is an acceptable accelerated induction compared with the standard divided dose for induction therapy in kidney transplant in a predominantly Black population.


Asunto(s)
Suero Antilinfocítico , Trasplante de Riñón , Suero Antilinfocítico/uso terapéutico , Rechazo de Injerto/prevención & control , Supervivencia de Injerto , Humanos , Inmunosupresores , Quimioterapia de Inducción , Trasplante de Riñón/efectos adversos , Estudios Retrospectivos
8.
Curr Pharm Teach Learn ; 14(2): 245-249, 2022 02.
Artículo en Inglés | MEDLINE | ID: mdl-35190169

RESUMEN

Background Limited literature is available evaluating retrospective student perceptions of the utility of a postgraduate preparation elective at graduation and career onset and its impact on residency match rates. This project sought to explore the perceived usefulness of a third-year elective course from 2016 to 2019 on post-graduation preparation and to compare the match rate of students enrolled vs. not enrolled in the elective. Impact The majority of students pursuing residency programs (94%) perceived the elective course as helpful in navigating the postgraduate training process. Of the students pursuing other employment, 77.8% found the elective to be helpful in navigating the employment process. The top five activities identified as most useful included: cover letters, letters of intent, and thank you cards overview; curriculum vitae workshop; interviewing tips; mock interviews; and overview of postgraduate training opportunities. The match rate was not statistically different between those who completed the elective (60.7%) vs. all school graduates (64.7%) (P =.70). Recommendations Consideration should be given to the topics to be included in this type of elective course depending on the targeted audience. Additionally, it may be more beneficial to introduce these types of topics and activities to students earlier in their didactic career and integrate them into different parts of the curriculum. Discussion The post-graduation preparation elective course was perceived positively by students in terms of preparing for their postgraduate plans. Limitations and confounders make it difficult to determine the true impact of this type of elective on successful residency match rates.


Asunto(s)
Internado y Residencia , Estudiantes de Farmacia , Humanos , Estudios Retrospectivos
9.
J Am Pharm Assoc (2003) ; 62(3): 685-692, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35144864

RESUMEN

Owing to the accessibility of pharmacists and frequency of their patient encounters, pharmacists may be in the unique position to help recognize the impact that social determinants of health (SDOH) have on a patient's health. The American Pharmacists Association wants to provide practical tools and resources for pharmacists to assess and mitigate SDOH with their patients. Through the use of a diabetes patient case and the Pharmacists' Patient Care Process (PPCP), this article will highlight a few of the numerous items available to provide culturally and linguistically tailored disease management and health literate and numerate communication and to improve food security. Using tools and resources to address SDOH in the context of the PPCP allows pharmacists to develop an even more patient- and person-centered care plan with the goal of achieving optimal patient outcomes and reducing health disparities. As pharmacists gain comfort with using these tools and resources to address SDOH in their practices, they should continue to seek opportunities to learn about other SDOH and their impact on patients' chronic medical conditions, including diabetes.


Asunto(s)
Diabetes Mellitus , Farmacéuticos , Diabetes Mellitus/terapia , Humanos , Atención al Paciente , Determinantes Sociales de la Salud , Encuestas y Cuestionarios
10.
J Am Pharm Assoc (2003) ; 62(3): 693-696, 2022.
Artículo en Inglés | MEDLINE | ID: mdl-35168875

RESUMEN

Health disparities are closely linked with economic, social, or environmental disadvantage and are the differences observed between groups as related to disease morbidity and mortality, injury, or violence. U.S. Food and Drug Administration Office of Minority Health and Health Equity and the American Pharmacists Association are both committed to the advancement of health equity and to increasing education and awareness of diabetes-related health disparity issues. Pharmacists are strategically located within the health care system and have the knowledge and skills to support the reduction of health disparities in patients with diabetes. This article highlights some of the many approaches and resources pharmacists can use in addressing health disparities and describes culturally competent, health literate, and numerate techniques for providing education and communicating with patients who have diabetes.


Asunto(s)
Diabetes Mellitus , Equidad en Salud , Comunicación , Atención a la Salud , Diabetes Mellitus/terapia , Disparidades en Atención de Salud , Humanos , Farmacéuticos , Estados Unidos
11.
Trauma Violence Abuse ; 23(2): 476-489, 2022 04.
Artículo en Inglés | MEDLINE | ID: mdl-32945244

RESUMEN

Despite the importance of understanding the prevalence, causes, and consequences of conflict and violence within families, the specific risk of violence following a family member's release from incarceration has been hard to ascertain. Research indicates that a significant percentage of persons released from incarceration will experience involvement in family violence in their life, yet it remains unclear whether this heightened risk exists due to larger family or structural contexts or whether incarceration itself leads to heightened risk of family violence after release. Using an integrative review methodology that combines results from both qualitative and quantitative studies, we review existing studies of family violence after incarceration to explore (1) the prevalence, (2) variation in measurement, (3) risk factors, and (4) protective factors for family violence after a family member's incarceration. Through a search of three separate databases for peer-reviewed and gray literature, we analyzed 26 studies that estimated any form of physical family violence after any family member had been incarcerated. Where reported, intimate partner violence occurs in almost a quarter of cases, although only four studies examine the prevalence of violence perpetrated against children by parents. Family violence history, weakened family support during incarceration, and substance use after release all emerged as persistent risk factors. Directions and opportunities for future research are discussed.


Asunto(s)
Violencia Doméstica , Violencia de Pareja , Trastornos Relacionados con Sustancias , Niño , Humanos , Prevalencia , Factores de Riesgo
12.
Int J STD AIDS ; 33(2): 186-192, 2022 02.
Artículo en Inglés | MEDLINE | ID: mdl-34872392

RESUMEN

INTRODUCTION: We assessed reproductive intentions and associated characteristics among men enrolled in the Sustainable Health Center Implementation pre-exposure prophylaxis (PrEP) Pilot (SHIPP) Study. METHODS: We analyzed baseline data from 1275 men who self-identified as gay or bisexual and participated in the SHIPP study. SHIPP was a cohort study of PrEP implementation in five community health centers in Chicago, Jackson, Philadelphia, and Washington, D.C. conducted from 2014 to 2016. Participants completed audio computer-assisted self-interviews querying intentions to have a child in the future. We estimated the association between participants' reproductive intentions and their characteristics using Poisson regression models. RESULTS: Approximately 47% of participants indicated their intentions to have a child. Black/non-Hispanic (aPR = 1.40; 95% CI: 1.10-1.78) and other/non-Hispanic participants (aPR = 1.40; 95% CI: 1.01-1.93) were more likely to report intentions to have a child than white/non-Hispanic participants. Participants were less likely to report intentions to have children as age increased (18-29 years, reference group; 30-39 years, aPR = 0.80, 95% CI: 0.64-0.99; 40-49 years, aPR = 0.49, 95% CI: 0.33-0.72; 50+ years, aPR = 0.07, 95% CI: 0.02-0.21). CONCLUSIONS: Clinicians offering PrEP to black and other/non-Hispanic gay and bisexual men should assess their reproductive intentions as family-planning counseling may be an opportunity to introduce PrEP to HIV-negative gay and bisexual men.


Asunto(s)
Infecciones por VIH , Profilaxis Pre-Exposición , Minorías Sexuales y de Género , Adolescente , Adulto , Niño , Estudios de Cohortes , Infecciones por VIH/tratamiento farmacológico , Infecciones por VIH/prevención & control , Homosexualidad Masculina/psicología , Humanos , Intención , Masculino , Proyectos Piloto , Adulto Joven
13.
J Assoc Nurses AIDS Care ; 31(6): 685-692, 2020.
Artículo en Inglés | MEDLINE | ID: mdl-32541194

RESUMEN

Preexposure prophylaxis (PrEP) is highly effective in preventing HIV among both men and women, with the reduction in risk directly linked to medication adherence. Navigation services and other adherence interventions have demonstrated efficacy in medication uptake; however, their use may not be fully integrated into clinic operations or their roles clearly defined. This quality improvement (QI) project developed an evidenced-based PrEP Navigation (PN) tool to identify patient-reported barriers to uptake and to support process improvement at a large community health center in Washington, DC. Outcomes related to patient-reported barriers, patient demographics, and time to medication pickup from the pharmacy were measured before and after implementation. A total of 198 patients were included in this analysis. Mean days from initial prescription to medication pickup was reduced by 1.42 days (p = .030) following PN tool implementation. The evidenced-based PN tool is modifiable to the needs of the individual clinic and the patients they care for to support wide-scale PrEP uptake and continuous system process improvements.


Asunto(s)
Fármacos Anti-VIH/administración & dosificación , Prestación Integrada de Atención de Salud/organización & administración , Infecciones por VIH/prevención & control , Cumplimiento de la Medicación , Navegación de Pacientes , Farmacia , Profilaxis Pre-Exposición , Mejoramiento de la Calidad , Retención en el Cuidado/estadística & datos numéricos , Adulto , Fármacos Anti-VIH/uso terapéutico , District of Columbia , Medicina de Emergencia Basada en la Evidencia , Práctica Farmacéutica Basada en la Evidencia , Femenino , Infecciones por VIH/tratamiento farmacológico , Humanos , Masculino , Evaluación de Programas y Proyectos de Salud
14.
AIDS Patient Care STDS ; 34(6): 259-266, 2020 06.
Artículo en Inglés | MEDLINE | ID: mdl-32484743

RESUMEN

We aimed to systematically evaluate the feasibility of integrating HIV prevention services, including pre-exposure prophylaxis (PrEP), into a family planning setting in a high-prevalence community. We used the RE-AIM Framework (Reach, Efficacy, Adoption, Implementation, Maintenance) to evaluate the integration of HIV prevention services into a family planning clinic over 6 months. Before the integration, PrEP was not offered. We implemented a staff training program on HIV PrEP. We determined the proportion of women presenting to the clinic who were screened, eligible for, and initiated PrEP through chart review. We assessed staff comfort with PrEP pre- and post-integration. We compared planned and actual implementation, interviewed staff to determine barriers and facilitators, and tracked systems adaptations. We assessed maintenance of PrEP after the study concluded. There were 640 clinical encounters for 515 patients; the rate of HIV counseling and PrEP screening was 50%. The rate was 10% in month 1 and peaked to 65% in month 3. Nearly all screened patients were eligible for PrEP (98.4%) and 15 patients (6%) initiated PrEP. Staff knowledge and comfort discussing PrEP improved after education. Facilitators included partnering with local experts, continuing education, clinical tools for providers, and patient education materials. Barriers included competing priorities during clinical encounters, limited woman-centered patient education materials, and insurance-related barriers. Embedding HIV prevention services in the family planning setting was feasible in this pilot. The proportion of women screened for PrEP rapidly increased. In this high HIV prevalence community, nearly all screened women were eligible and 6% initiated PrEP.


Asunto(s)
Fármacos Anti-VIH/administración & dosificación , Prestación Integrada de Atención de Salud/organización & administración , Servicios de Planificación Familiar/estadística & datos numéricos , Infecciones por VIH/prevención & control , Tamizaje Masivo/estadística & datos numéricos , Profilaxis Pre-Exposición/métodos , Adulto , Instituciones de Atención Ambulatoria , Fármacos Anti-VIH/uso terapéutico , Estudios de Cohortes , Consejo , Servicios de Planificación Familiar/organización & administración , Femenino , Infecciones por VIH/tratamiento farmacológico , Humanos , Estudios Prospectivos , Educación Sexual , Parejas Sexuales
15.
Health Serv Res ; 55(4): 524-530, 2020 08.
Artículo en Inglés | MEDLINE | ID: mdl-32196656

RESUMEN

OBJECTIVE: To evaluate whether out-of-pocket (OOP) costs reduced HIV pre-exposure prophylaxis (PrEP) persistence. DATA SOURCE: Participants from five urban community health centers (CHCs) in four US cities enrolled in a PrEP demonstration project from September 2014 to August 2017. STUDY DESIGN: Patients initiating PrEP were followed quarterly until they withdrew from PrEP care or the study ended. Self-reported OOP medication and clinic visit costs were assessed by semiannual questionnaires. Persistence was defined as the time from study enrollment to the last visit after which two subsequent 3-month visits were missed. Multivariable Cox proportional hazard regression was used to assess the effect of demographics, insurance, and OOP costs on PrEP persistence. PRINCIPAL FINDINGS: Among 918 participants with OOP cost data, the average quarterly OOP cost was $34 (median: $5, IQR: $0-$25). Participants who were men, White, employed, completed college, and had commercial insurance had higher OOP costs. Higher OOP costs were not associated with lower PrEP persistence by Cox proportional hazards regression (adjusted hazard ratio = 1.00 per $50 increase, 95% CI = 0.97, 1.02). CONCLUSION: Among patients receiving care from these urban CHCs, OOP costs were low and did not undermine PrEP persistence.


Asunto(s)
Centros Comunitarios de Salud/economía , Infecciones por VIH/prevención & control , Gastos en Salud/estadística & datos numéricos , Hospitales Urbanos/economía , Cumplimiento de la Medicación/estadística & datos numéricos , Profilaxis Pre-Exposición/economía , Profilaxis Pre-Exposición/estadística & datos numéricos , Adolescente , Adulto , Niño , Centros Comunitarios de Salud/estadística & datos numéricos , Femenino , Hospitales Urbanos/estadística & datos numéricos , Humanos , Masculino , Persona de Mediana Edad , Estados Unidos , Adulto Joven
16.
AIDS ; 34(8): 1181-1186, 2020 07 01.
Artículo en Inglés | MEDLINE | ID: mdl-32205724

RESUMEN

OBJECTIVE: The optimal screening frequency of sexually transmitted infections (STIs) for MSM and transgender women (TGW) on HIV pre-exposure prophylaxis (PrEP) is unclear, with present guidelines recommending screening every 3-6 months. We aimed to determine the number of STIs for which treatment would have been delayed without quarterly screening. DESIGN: The US PrEP Demonstration Project was a prospective, open-label cohort study that evaluated PrEP delivery in STI clinics in San Francisco and Miami, and a community health center in Washington, DC. In all, 557 HIV-uninfected MSM and TGW were offered up to 48 weeks of PrEP and screened quarterly for STIs. METHODS: The proportion of gonorrhea, chlamydia, and syphilis infections for which treatment would have been delayed had screening been conducted every 6 versus every 3 months was determined by taking the number of asymptomatic STIs at weeks 12 and 36 divided by the total number of infections during the study follow-up period for each STI. RESULTS: Among the participants, 50.9% had an STI during follow-up. If screening had been conducted only semiannually or based on symptoms, identification of 34.3% of gonorrhea, 40.0% of chlamydia, and 20.4% of syphilis infections would have been delayed by up to 3 months. The vast majority of participants (89.2%) with asymptomatic STIs reported condomless anal sex and had a mean of 8.1 partners between quarterly visits. CONCLUSIONS: Quarterly STI screening among MSM on PrEP could prevent a substantial number of partners from being exposed to asymptomatic STIs, and decrease transmission.


Asunto(s)
Prestación Integrada de Atención de Salud/organización & administración , Infecciones por VIH/prevención & control , Homosexualidad Masculina , Tamizaje Masivo/estadística & datos numéricos , Profilaxis Pre-Exposición , Enfermedades de Transmisión Sexual/diagnóstico , Personas Transgénero , Adolescente , Adulto , Anciano , Infecciones por Chlamydia/diagnóstico , Infecciones por Chlamydia/epidemiología , Infecciones por Chlamydia/prevención & control , Estudios de Cohortes , Femenino , Gonorrea/diagnóstico , Gonorrea/epidemiología , Gonorrea/prevención & control , Infecciones por VIH/diagnóstico , Infecciones por VIH/epidemiología , Humanos , Masculino , Persona de Mediana Edad , Estudios Prospectivos , San Francisco/epidemiología , Enfermedades de Transmisión Sexual/epidemiología , Enfermedades de Transmisión Sexual/prevención & control , Adulto Joven
17.
Curr Pharm Teach Learn ; 11(9): 888-894, 2019 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-31570125

RESUMEN

INTRODUCTION: The purpose of this study was to evaluate the influence generational categories may have on commonalities among pharmacy students and their pharmacist preceptors during advanced pharmacy practice experiences (APPEs). METHODS: Multiple-choice surveys aimed at evaluating generational characteristics were sent to pharmacy students and their preceptors during the first three APPEs. Questions focused on six key areas: preferred learning/teaching style, view of career/work, communication style, view of technology, life outlook, and personal characteristics. Each response corresponded to a generational category (Veteran, Baby Boomer, Generation X, Millennial). Students and preceptors were instructed to apply each question to themselves; students then applied each question to their preceptor, while preceptors applied the questions to students. RESULTS: Twenty-six percent of students and 35% of preceptors completed at least one generational survey. Students selected the option that corresponded to their actual generational category significantly more often compared to preceptors (2.133 ±â€¯0.815 vs. 1.632 ±â€¯1.132, p = 0.007). Although none of the respondents belonged to the Veteran category, responses corresponding to this generation represented the second highest number of responses selected by students and preceptors alike. CONCLUSIONS: Students and preceptors identified with characteristics outside their actual generational category. In addition, both groups selected options such as working to make a difference that may correlate more with people who have chosen pharmacy as a profession. Pharmacist awareness of generational similarities may lead to a more successful student-preceptor relationship.


Asunto(s)
Relaciones Intergeneracionales , Preceptoría/normas , Estudiantes de Farmacia/psicología , Adulto , Anciano , Educación en Farmacia/métodos , Educación en Farmacia/normas , Educación en Farmacia/estadística & datos numéricos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Preceptoría/métodos , Preceptoría/estadística & datos numéricos , Estudiantes de Farmacia/estadística & datos numéricos , Encuestas y Cuestionarios
18.
J Acquir Immune Defic Syndr ; 81(2): 158-162, 2019 06 01.
Artículo en Inglés | MEDLINE | ID: mdl-31095005

RESUMEN

BACKGROUND: Objective adherence metrics for tenofovir (TFV) disoproxil fumarate/emtricitabine (FTC)-based pre-exposure prophylaxis (PrEP) were critical for interpretation of efficacy in PrEP clinical trials, and there is increasing interest in using drug levels to tailor interventions for reengagement and adherence. Point-of-care immunoassays for TFV, which examine short-term adherence, are in development. However, the ability of poor short-term and long-term adherence to predict future PrEP nonretention is unknown. SETTING: Secondary data analysis of a large, prospective multi-site U.S. PrEP demonstration project. METHODS: An adjusted Cox-proportional hazards model examined the relationship of dried blood spot (DBS) levels of FTC-triphosphate (FTC-TP) or TFV-diphosphate (TFV-DP), measures of short-term and long-term PrEP adherence, respectively, with future study nonretention. RESULTS: Overall, 294 individuals (median age 33 years) contributed drug levels within the U.S. PrEP demonstration project. By the end of study, 27% were lost to follow-up, 25% had at least one undetectable FTC-TP level indicating poor short-term adherence, and 29% had a drug level indicating suboptimal long-term adherence (TFV-DP <700 fmol/punch). The strongest factor associated with future study nonretention using a binary drug-level cut-off was an undetectable DBS FTC-TP level (adjusted hazard ratio 6.3; 95% confidence interval 3.8 to 10.2). The suboptimal long-term adherence based on low DBS TFV-DP levels was also associated with nonretention (adjusted hazard ratio 4.3; 95% confidence interval: 2.4 to 7.6). CONCLUSIONS: Both short- and long-term metrics of PrEP adherence are strongly associated with future loss to follow-up in a U.S. demonstration project study. Short-term metrics of adherence, once available at the point-of-care, could be used to direct real-time tailored retention and adherence interventions.


Asunto(s)
Fármacos Anti-VIH/sangre , Infecciones por VIH/prevención & control , Cumplimiento de la Medicación , Pruebas en el Punto de Atención , Profilaxis Pre-Exposición , Adenina/análogos & derivados , Adenina/sangre , Adenina/farmacocinética , Adenina/uso terapéutico , Adulto , Fármacos Anti-VIH/farmacocinética , Fármacos Anti-VIH/uso terapéutico , Pruebas con Sangre Seca/métodos , Emtricitabina/análogos & derivados , Emtricitabina/sangre , Emtricitabina/farmacocinética , Emtricitabina/uso terapéutico , Femenino , Infecciones por VIH/sangre , Infecciones por VIH/tratamiento farmacológico , Homosexualidad Masculina , Humanos , Masculino , Organofosfatos/sangre , Organofosfatos/farmacocinética , Organofosfatos/uso terapéutico , Modelos de Riesgos Proporcionales , Estudios Prospectivos , Tenofovir/sangre , Tenofovir/farmacocinética , Tenofovir/uso terapéutico
19.
Curr Pharm Teach Learn ; 10(9): 1272-1279, 2018 09.
Artículo en Inglés | MEDLINE | ID: mdl-30497631

RESUMEN

BACKGROUND AND PURPOSE: To determine if a disease state simulation assignment increases empathy, comfort, and knowledge in diabetes nutrition counseling. EDUCATIONAL ACTIVITY AND SETTING: One-hundred forty students completing ambulatory care experiential rotations over two academic years were invited to participate in the study. Students in the intervention group completed an empathy assignment, which involved developing and following a diet plan appropriate for a patient with diabetes followed by a reflection of their experiences. Students completed a pre- and post-intervention survey assessing empathy, comfort with counseling, and knowledge of diabetes nutrition. FINDINGS: Fifty-three students (31 in the intervention, 22 in the non-intervention group) completed the pre- and post-survey and provided informed consent. Empathy scores on the Kiersma Chen Empathy Scale (range 15-105) improved by 6.4 points in students in the intervention group compared to a decline of 1.2 in students in the non-intervention group (p = 0.045). Comfort in counseling on a diabetes diet, measured on a 10-point scale, increased significantly more in students completing the empathy assignment (4.7 vs 3.5; p = 0.044). Knowledge (0-100%) improved by 9.7% and 8.6% in the intervention and non-intervention groups, respectively (p = 0.859). DISCUSSION: Similar to other studies using disease state simulations, the findings of this study show increased confidence in counseling and empathy. Given that the assignment used in this study is more specific to nutrition counseling, its use may be most helpful in settings where pharmacists are responsible for diabetes nutrition counseling. SUMMARY: Implementation of a similar assignment could be considered for experiential rotations with nutrition counseling.


Asunto(s)
Consejo/educación , Diabetes Mellitus/dietoterapia , Empatía , Simulación de Paciente , Estudiantes de Farmacia/psicología , Adulto , Actitud del Personal de Salud , Consejo/métodos , Educación en Farmacia/métodos , Femenino , Humanos , Masculino , Psicometría/instrumentación , Psicometría/métodos , Psicometría/estadística & datos numéricos , Estudiantes de Farmacia/estadística & datos numéricos , Encuestas y Cuestionarios
20.
Curr Pharm Teach Learn ; 10(8): 1132-1137, 2018 08.
Artículo en Inglés | MEDLINE | ID: mdl-30314550

RESUMEN

BACKGROUND AND PURPOSE: The primary purpose of this study was to evaluate student's perceptions of a student led journal club. EDUCATIONAL ACTIVITY AND SETTING: There were four, paired student led journal club sessions throughout the five week Women's and Men's Health Pharmacotherapy course. Journal club topics expanded upon didactic lecture material. A voluntary end-of-course survey was administered. Survey questions pertained to student's perception of the activity. Course and journal club grades were collected to identify correlations between demographics and performance. FINDINGS: All 91 students were given the survey (92.3% completion rate). Most students had not completed the journal club elective course or a journal club presentation previously (84.5% and 70.2%, respectively). Post-intervention prior to the course, most students did not feel confident in evaluating primary literature or presenting a journal club (61.9% and 59.5%, respectively). By the end of the course, most students felt an improvement in confidence in evaluating primary literature and presenting a journal club (88.1% and 89.3%, respectively). Most students agreed the journal club activities adequately complemented course material and was a beneficial course component (84.5% and 85.7%, respectively). Students felt better prepared for their Doctoral Candidate Seminar and pharmacy year four experiential rotations (76.1% and 86.9% respectively). Overall students reported that the journal club activity should be included in future courses (79.7%). The only parameter that predicted student confidence to present the journal club was completion of a journal club prior to the course. (p = 0.013) SUMMARY: Students perceived the journal club presentation in a pharmacotherapy module to be beneficial and agreed it should be included in future courses.


Asunto(s)
Quimioterapia/métodos , Percepción , Estudiantes de Farmacia/psicología , Escritura/normas , Curriculum/normas , Educación en Farmacia/métodos , Evaluación Educacional/métodos , Humanos , Estudiantes de Farmacia/estadística & datos numéricos , Encuestas y Cuestionarios
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