RESUMEN
Many tissues have been analyzed for their relevance in prediction of blood ethanol concentrations, with varying results. Synovial fluid is contained and protected by the bursa sac. Because of its high water content, it may be a suitable biological fluid for analysis if a linear correlation could be established between blood and synovial fluid ethanol concentrations. Blood-synovial fluid ratios of ethanol in 28 human cadavers, using an internal standard, exhibit a good distribution ratio with an average of 0.99 +/- 0.29 and a correlation coefficient of 0.89. This study shows that synovial fluid is a good alternative biological sample for prediction of blood ethanol levels within a range.
Asunto(s)
Etanol/análisis , Etanol/sangre , Líquido Sinovial/química , Cromatografía de Gases y Espectrometría de Masas , HumanosRESUMEN
A postmortem case involving ingestion of a strychnine-containing preparation is reported. Strychnine levels were determined in blood, urine, bile, liver, kidney, stomach contents, small and large intestines, and brain. The procedure, which is sensitive and specific, employs a gas-liquid chromatograph equipped with a flame ionization detector (FID). The extraction procedure using 5 mL of body fluids or tissue homogenate is described in detail. This is the first strychnine mortality in Allegheny County within a period of 20 years.
Asunto(s)
Estricnina/envenenamiento , Cromatografía de Gases , Humanos , Masculino , Persona de Mediana Edad , Estricnina/análisisRESUMEN
Postmortem pentobarbital levels in rabbit heart blood and bone marrow were determined and compared. The average ratio of femur marrow/blood pentobarbital concentrations in 24 rabbits was 1.06 +/- 0.05. The average percent difference between actual plasma pentobarbital concentrations and calculated plasma pentobarbital concentrations was 5.82 +/- 1.96. Concentrations were determined by gas chromatography of extracted, derivatized pentobarbital.
Asunto(s)
Médula Ósea/metabolismo , Pentobarbital/metabolismo , Animales , Cromatografía de Gases , Pentobarbital/sangre , ConejosAsunto(s)
Anfetaminas/envenenamiento , 2,5-Dimetoxi-4-Metilanfetamina/envenenamiento , Alucinógenos/envenenamiento , 2,5-Dimetoxi-4-Metilanfetamina/análogos & derivados , 2,5-Dimetoxi-4-Metilanfetamina/análisis , Adulto , Cromatografía de Gases , Cromatografía en Capa Delgada , Femenino , Alucinógenos/análisis , Humanos , Espectrofotometría Infrarroja , Espectrofotometría Ultravioleta , Distribución TisularRESUMEN
Two fatal cases are presented involving the acute ingestion of theophylline resulting in blood theophylline concentrations greater than one hundred times the accepted therapeutic range.
