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1.
Physiol Biochem Zool ; 90(2): 257-272, 2017.
Artículo en Inglés | MEDLINE | ID: mdl-28277961

RESUMEN

Sharks migrate annually over large distances and occupy a wide variety of habitats, complicating analysis of lifestyle and diet. A biogeochemical technique often used to reconstruct shark diet and environment preferences is stable isotope analysis, which is minimally invasive and integrates through time and space. There are previous studies that focus on isotopic analysis of shark soft tissues, but there are limited applications to shark teeth. However, shark teeth offer an advantage of multiple ecological snapshots and minimum invasiveness during removal because of their distinct conveyor belt tooth replacement system. In this study, we analyze δ13C and δ15N values of the organic matrix in leopard shark teeth (Triakis semifasciata) from a captive experiment and report discrimination factors as well as incorporation rates. We found differences in tooth discrimination factors for individuals fed different prey sources (mean ± SD; Δ13Csquid = 4.7‰ ± 0.5‰, Δ13Ctilapia = 3.1‰ ± 1.0‰, Δ15Nsquid = 2.0‰ ± 0.7‰, Δ15Ntilapia = 2.8‰ ± 0.6‰). In addition, these values differed from previously published discrimination factors for plasma, red blood cells, and muscle of the same leopard sharks. Incorporation rates of shark teeth were similar for carbon and nitrogen (mean ± SE; λC = 0.021 ± 0.009, λN = 0.024 ± 0.007) and comparable to those of plasma. We emphasize the difference in biological parameters on the basis of tissue substrate and diet items to interpret stable isotope data and apply our results to stable isotope values from blue shark (Prionace glauca) teeth to illustrate the importance of biological parameters to interpret the complex ecology of a migratory shark.


Asunto(s)
Carbono/metabolismo , Nitrógeno/metabolismo , Tiburones/fisiología , Diente/química , Alimentación Animal , Animales , Isótopos de Carbono , Isótopos de Nitrógeno , Diente/metabolismo
2.
Respir Physiol ; 127(2-3): 157-72, 2001 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-11504587

RESUMEN

Opioid modulation of breathing during postnatal development through to the adult was investigated in the rat. Respiratory frequency, tidal volume and minute volume were recorded in unanesthetized, unrestrained rat pups and adults using barometric plethysmography. Subjects were administered the highly selective mu opioid agonists dermorphin and fentanyl. Fentanyl, which readily crosses the blood-brain barrier, was included to ensure that developmental changes in blood-brain barrier restrictions did not mask some of the dermorphin effects in older neonates. Drugs were administered subcutaneously in neonates and adults, although dermorphin was given by intracerebroventricular route only in adults. In neonates, mu agonist administration caused a gasping-like pattern of breathing, characterized by a marked fall in frequency and a smaller increase in tidal volume. The gasping response was prevented by pre-treatment with the long-acting mu1 antagonist naloxonazine (NALZ). In the presence of NALZ, mu agonists elicited only a small, but significant, reduction in tidal volume. Both dermorphin and fentanyl showed more potent activity in younger pups than in older pups, possibly in the case of dermorphin because of developmental maturation of blood-brain barrier function. In adults, fentanyl and dermorphin both caused a reduction in frequency and minute volume. The response of adults to fentanyl, but not dermorphin, was prevented by NALZ. These results suggest that both mu1 and mu2 receptors contribute to opioid-induced respiratory depression during neonatal and adult life.


Asunto(s)
Pulmón/fisiología , Naloxona/análogos & derivados , Receptores Opioides mu/fisiología , Mecánica Respiratoria/fisiología , Factores de Edad , Analgésicos Opioides/farmacología , Animales , Animales Recién Nacidos , Femenino , Fentanilo/farmacología , Masculino , Naloxona/farmacología , Oligopéptidos/farmacología , Péptidos Opioides , Ratas , Ratas Wistar , Receptores Opioides mu/agonistas , Receptores Opioides mu/antagonistas & inhibidores , Mecánica Respiratoria/efectos de los fármacos , Volumen de Ventilación Pulmonar/efectos de los fármacos , Volumen de Ventilación Pulmonar/fisiología
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