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1.
Sci Rep ; 10(1): 21990, 2020 12 15.
Artículo en Inglés | MEDLINE | ID: mdl-33319785

RESUMEN

Human brain activity is intrinsically organized into resting-state networks (RSNs) that transiently activate or deactivate at the sub-second timescale. Few neuroimaging studies have addressed how Alzheimer's disease (AD) affects these fast temporal brain dynamics, and how they relate to the cognitive, structural and metabolic abnormalities characterizing AD. We aimed at closing this gap by investigating both brain structure and function using magnetoencephalography (MEG) and hybrid positron emission tomography-magnetic resonance (PET/MR) in 10 healthy elders, 10 patients with subjective cognitive decline (SCD), 10 patients with amnestic mild cognitive impairment (aMCI) and 10 patients with typical Alzheimer's disease with dementia (AD). The fast activation/deactivation state dynamics of RSNs were assessed using hidden Markov modeling (HMM) of power envelope fluctuations at rest measured with MEG. Correlations were sought between temporal properties of HMM states and participants' cognitive test scores, whole hippocampal grey matter volume and regional brain glucose metabolism. The posterior default-mode network (DMN) was less often activated and for shorter durations in AD patients than matched healthy elders. No significant difference was found in patients with SCD or aMCI. The time spent by participants in the activated posterior DMN state did not correlate significantly with cognitive scores, nor with the whole hippocampal volume. However, it correlated positively with the regional glucose consumption in the right dorsolateral prefrontal cortex (DLPFC). AD patients present alterations of posterior DMN power activation dynamics at rest that identify an additional electrophysiological correlate of AD-related synaptic and neural dysfunction. The right DLPFC may play a causal role in the activation of the posterior DMN, possibly linked to the occurrence of mind wandering episodes. As such, these data might suggest a neural correlate of the decrease in mind wandering episodes reported in pathological aging.


Asunto(s)
Enfermedad de Alzheimer/fisiopatología , Red Nerviosa/fisiopatología , Descanso/fisiología , Anciano , Encéfalo/metabolismo , Encéfalo/patología , Encéfalo/fisiopatología , Mapeo Encefálico , Cognición , Femenino , Humanos , Magnetoencefalografía , Masculino , Factores de Tiempo
2.
Eur Ann Otorhinolaryngol Head Neck Dis ; 136(3S): S53-S55, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-30872004

RESUMEN

INTRODUCTION: Pulsatile tinnitus is a sound generated by an acoustic source from within the body, which is perceived by the auditory system of the patient. CASES SUMMARY: We report two puzzling cases of pulsatile tinnitus with normal ENT examinations: the first was due to a cervical internal carotid artery dissection, and the second to the compression of the foramina of Monro by a craniopharyngioma, leading to hydrocephalus. DISCUSSION: We review the systematic management and emphasize the decisive role of the ENT clinician regarding this pulsatile tinnitus complaint, because of the potentially severe complications of its underlying pathology.


Asunto(s)
Disección de la Arteria Carótida Interna/complicaciones , Craneofaringioma/complicaciones , Hidrocefalia/etiología , Neoplasias Hipofisarias/complicaciones , Acúfeno/etiología , Adenoidectomía/efectos adversos , Adulto , Traumatismos de las Arterias Carótidas/diagnóstico por imagen , Disección de la Arteria Carótida Interna/diagnóstico por imagen , Ventrículos Cerebrales , Niño , Angiografía por Tomografía Computarizada , Craneofaringioma/diagnóstico por imagen , Femenino , Humanos , Imagen por Resonancia Magnética , Masculino , Neoplasias Hipofisarias/diagnóstico por imagen , Complicaciones Posoperatorias/etiología , Pulso Arterial
3.
JBR-BTR ; 96(6): 369-71, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-24617181

RESUMEN

We present a case of chronic hydrocephalus discovered in adulthood through an episode of acute decompensation. Multimodal imaging revealed the cause of this hydrocephalus to be a membranous septum of the aqueduct of Sylvius, a condition for which few reports exist.


Asunto(s)
Acueducto del Mesencéfalo/diagnóstico por imagen , Acueducto del Mesencéfalo/patología , Hidrocefalia/diagnóstico , Imagen por Resonancia Magnética/métodos , Imagen Multimodal/métodos , Tomografía Computarizada por Rayos X/métodos , Adulto , Acueducto del Mesencéfalo/cirugía , Enfermedad Crónica , Constricción Patológica/complicaciones , Medios de Contraste , Diagnóstico Diferencial , Humanos , Hidrocefalia/etiología , Yohexol , Masculino , Intensificación de Imagen Radiográfica/métodos
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