1.
Pharmazie
; 58(2): 140-2, 2003 Feb.
Artículo
en Inglés
| MEDLINE
| ID: mdl-12641333
RESUMEN
Tecostanine (1) was isolated from Tecoma stans leaves. Its sterochemistry was elucidated as well as its antihyperglycemic activity and its affinity to opioid and nicotinic receptors. The oxalate salt of 1 did not significantly affect blood glucose levels in normoglycaemic and hyperglycaemic rats. It did not appear to interact with opioid receptors (mu type) and showed only moderate affinity to the nicotinic receptor.
Asunto(s)
Alcaloides/química , Alcaloides/farmacología , Bignoniaceae/química , Hipoglucemiantes/química , Hipoglucemiantes/farmacología , Plantas Medicinales/química , Terpenos/química , Terpenos/farmacología , Animales , Cristalografía por Rayos X , Espectroscopía de Resonancia Magnética , Masculino , México , Modelos Moleculares , Conformación Molecular , Ratas , Ratas Sprague-Dawley , Receptores Nicotínicos/efectos de los fármacos , Receptores Opioides/efectos de los fármacos
2.
Planta Med
; 61(3): 217-20, 1995 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-7617762
RESUMEN
Two biflavonoids were isolated from the EtOH extract from leaves of Ouratea spectabilis. Their structures were established to be the novel 6,6"-bigenkwanin and 7,7"-dimethoxyagathisflavone on the basis of spectroscopic data. The inhibition of bovine lens aldose reductase exerted by these biflavones has been studied.