RESUMEN
Synthetic strategies towards pyrroles within chiral frameworks are summarised, focussing on reports published 2010-2023. The synthesis of pyrroles featuring substituents bearing chiral centres are summarised, as are those whereby pyrroles are located within axially chiral systems courtesy of restricted bond rotation.
RESUMEN
We report a versatile method for cross-coupling of NH-sulfoximines with (hetero)aryl chlorides, as well as bromide and sulfonate electrophiles, that makes use of the air-stable, commercial precatalyst (PhPAd-DalPhos)Ni(o-tol)Cl. Under optimized conditions a diverse electrophile scope is established, including the N-arylation of the pharmaceutical Clozapine. While 5 mol % Ni and 80 °C are commonly employed in this chemistry, successful examples utilizing 1 mol % Ni and/or 25 °C are presented. Competition experiments establish the superiority of NH-sulfoximine over primary sulfonamide as nucleophiles under these conditions.