Post-operative Surveillance Following Curative Resection of Colorectal Cancer in the Elderly Population in the United Kingdom: An Observational Study.

Background Colorectal cancer most commonly affects the elderly population. Post-colorectal cancer surveillance aims to reduce cancer incidence and mortality, but its necessity and effectiveness are debated, especially in the elderly population. This study explores the relevance of computer tomography (CT) and colonoscopy surveillance in patients aged 75 and over who have undergone curative resection for colorectal cancer. Methods A retrospective analysis of prospectively collected data was conducted on patients aged 75 and over who had undergone surgical resection of colorectal cancer between November 2014 and August 2021. Data on demographics, treatment, survival, and surveillance were gathered from electronic patient records. The primary outcome was adherence to follow-up colonoscopy and CT-scan surveillance following surgery. Results A total of 417 patients underwent colorectal cancer surgery, with 334 included for analysis. The cohort had an average age of 81 years, with the majority receiving laparoscopic surgery and primary anastomosis. Twelve-month CT surveillance showed normal results in 281 patients (91.8%), while 24-month CT surveillance demonstrated normal findings in 244 patients (88.7%). Only 175 patients (52.4%) had colonoscopy follow-up, with 94 (53.7%) showing normal results, 74 (42.3%) demonstrating benign polyps, and two patients (1.1%) having histologically proven cancer. Reasons for not undergoing colonoscopy included declining invitations (30 patients, 19.1%) and being too frail (45 patients, 28.7%). Conclusion This study reinforces the notion that colonoscopy surveillance for patients over the age of 75 may have limited benefits. In an ageing population, the benefits of surveillance in terms of early detection of recurrence must be balanced against the risks of harm from the procedure, the availability of further management, cost-effectiveness, and patient preferences. An individualised approach should be adopted, potentially with colonoscopy surveillance only recommended in patients of higher risk (extramural venous invasion (EMVI)) and a low frailty score with a life expectancy over 10 years.

Appendiceal neuroendocrine neoplasms in the era of laparoscopic appendicectomy.

BACKGROUND: Incidental appendiceal neuroendocrine neoplasms are identified in 1% of surgical resections for suspected appendicitis. A proportion of these patients will require further surgery because of high risk features, which include mesoappendiceal involvement or an involved margin. While an open appendicectomy technique usually involves en bloc mesoappendiceal resection, the increasingly common laparoscopic method often skeletonizes the appendix, leaving the mesoappendix in situ. This retrospective observational study investigates whether routine resection of the mesoappendix rather than skeletonization would reduce the need for further surgery in patients with an incidental finding of appendiceal neuroendocrine neoplasm. METHODS: We included appendicectomies performed over an 11-year period at Auckland City Hospital and identified all cases of incidental appendiceal neuroendocrine neoplasms. Histological data were collected to assess the risk of lymphatic spread and need for further surgery. Mesoappendix resection versus preservation and its effect on the recommendation for further surgery was recorded. RESULTS: An appendiceal neuroendocrine neoplasm was present in 73 (1%) of 7109 appendicectomy specimens. Of these, 10 patients (14%) required right hemicolectomy. Five of these could potentially have been spared the need for further surgery had the mesoappendix been removed en bloc with the appendix. DISCUSSION: We recommend en bloc mesoappendix resection during appendicectomy in order to better stage the neoplasm and reduce the need for unnecessary further surgery.

Laparoscopic adult colorectal surgeon and adolescents with inflammatory bowel disease: a safe combination?

INTRODUCTION: A multidisciplinary tertiary service for adolescents with inflammatory bowel disease (IBD) was commenced in April 2008, aiming to provide specialist treatment for adolescent patients and bridge the gap between existing paediatric and adult surgical services. A single laparoscopic colorectal surgeon who normally treats adult patients has been part of the multidisciplinary team since its inception. AIM: To analyse outcomes for those patients requiring surgical resection during the first 2 years of service. METHODS: In this service evaluation study, all data for patients undergoing surgery from 1 April 2008 to 31 March 2010 were prospectively collected on a dedicated electronic database. RESULTS: Nineteen patients underwent surgical resection (15 laparoscopic and four open) over the 2-year period. Median patient age was 15 years (range 11-16), and 14 patients were female. Of the 15 laparoscopic resections, eight were subtotal colectomy and ileostomy and seven ileocaecal resection/right hemicolectomy. There was one (6.7%) conversion due to a pericolic abscess. There were four planned open cases, including two subtotal colectomy and ileostomy and two small bowel resections. Median operating time was 150 and 172.5 min in the open and laparoscopic groups respectively. Median length of stay was 6 days (range 3-16) in the laparoscopic group, and 8 days (range 5-13) in the open group. There were three (15.8%) post-operative complications, one (5.3%) readmission within 30 days and no mortality. CONCLUSION: This study suggests that an adult colorectal surgeon can provide a safe and effective service for adolescents with IBD, including the provision of laparoscopic resection in this challenging patient group.

Apoptosis in the colonic crypt, colorectal adenomata, and manipulation by chemoprevention.

This review discusses the biology and the methods of assessment of apoptosis, of which, the monoclonal antibody M30 would seem to be the most useful; the role of apoptosis in the etiology of colorectal cancer; and its use as a marker to monitor the beneficial effects of chemopreventative interventions to reduce the development of colorectal cancer within the context of clinical trials.

Eight years experience of high-powered endoscopic diode laser therapy for palliation of colorectal carcinoma.

PURPOSE: Endoscopic laser therapy using neodymium: yttrium-aluminum-garnet (Nd:YAG) laser has been shown to be effective in palliating symptoms of obstruction, bleeding, and discharge in patients with colorectal cancer. These patients usually have advanced inoperable disease at presentation or are unfit for surgery. We have used high-powered diode laser to palliate patients with inoperable colorectal cancer since 1994. This study was designed to determine the success rate of high-powered diode laser in palliating inoperable colorectal carcinoma and compare these figures with those published for Nd:YAG laser. METHODS: A retrospective analysis was performed of all patients undergoing high-powered diode laser therapy for colorectal carcinoma between June 1994 and October 2002 (inclusive) at St. George's Hospital, London, United Kingdom. Patient's notes and endoscopy records were reviewed to determine the indications for treatment, success of symptom palliation, complications, and survival for each patient. RESULTS: Fifty-seven patients (28 males), with a median age at first treatment of 82 (range, 51-93) years, were identified who had been palliated with high-powered diode laser therapy for colorectal carcinoma. The median number of treatments received by each patient was three (range, 1-16 treatments), with a median interval between treatments of 9.5 (range, 1-25) weeks. Lifelong palliation of symptoms occurred in 51 patients (89 percent). Major complications were two perforations and one hemorrhage, giving an overall complication rate of 5.3 percent. One of the patients who experienced perforation died, giving an overall mortality rate of 1.8 percent for the procedure. The median survival of the 51 patients palliated completely by laser therapy was 8.5 (range, 0.6-52) months, with a probability of survival at 24 months of 15 percent. CONCLUSIONS: High-powered diode laser therapy is an effective method of providing palliation for obstruction, bleeding, and discharge in those patients with inoperable colorectal carcinoma. It produces results comparable to therapy with Nd:YAG laser and the equipment is cheaper, more compact, and portable.

28-Day emergency surgical re-admission rates as a clinical indicator of performance.

With the introduction of clinical governance, the NHS Executive has identified 28-day emergency re-admission rates as a clinical indicator to be used to assess and compare performance between NHS trusts. We undertook a 3-month retrospective audit of patients identified from the trust computer as having been re-admitted as an emergency within 28 days of discharge from the general surgical division. We wanted to examine reasons for re-admission, possible errors in coding and any preventable factors in these patients subsequently re-admitted acutely.