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1.
Arch Clin Neuropsychol ; 37(8): 1662-1687, 2022 Nov 21.
Artículo en Inglés | MEDLINE | ID: mdl-35704852

RESUMEN

OBJECTIVE: This study examined the relative contribution of performance and symptom validity in litigating adults with traumatic brain injury (TBI), as a function of TBI severity, and examined the relationship between self-reported emotional symptoms and cognitive tests scores while controlling for validity test performance. METHOD: Participants underwent neuropsychological assessment between January 2012 and June 2021 in the context of compensation-seeking claims related to a TBI. All participants completed a cognitive test battery, the Personality Assessment Inventory (including symptom validity tests; SVTs), and multiple performance validity tests (PVTs). Data analyses included independent t-tests, one-way ANOVAs, correlation analyses, and hierarchical multiple regression. RESULTS: A total of 370 participants were included. Atypical PVT and SVT performance were associated with poorer cognitive test performance and higher emotional symptom report, irrespective of TBI severity. PVTs and SVTs had an additive effect on cognitive test performance for uncomplicated mTBI, but less so for more severe TBI. The relationship between emotional symptoms and cognitive test performance diminished substantially when validity test performance was controlled, and validity test performance had a substantially larger impact than emotional symptoms on cognitive test performance. CONCLUSION: Validity test performance has a significant impact on the neuropsychological profiles of people with TBI, irrespective of TBI severity, and plays a significant role in the relationship between emotional symptoms and cognitive test performance. Adequate validity testing should be incorporated into every neuropsychological assessment, and associations between emotional symptoms and cognitive outcomes that do not consider validity testing should be interpreted with extreme caution.


Asunto(s)
Lesiones Traumáticas del Encéfalo , Adulto , Humanos , Pruebas Neuropsicológicas , Lesiones Traumáticas del Encéfalo/complicaciones , Emociones , Autoinforme , Cognición , Reproducibilidad de los Resultados
2.
Neuropsychol Rev ; 32(4): 758-806, 2022 12.
Artículo en Inglés | MEDLINE | ID: mdl-34694543

RESUMEN

A thorough understanding of the relationship between cognitive test performance and symptoms of depression, anxiety, or post-traumatic stress disorder (PTSD) in people with traumatic brain injury (TBI) is important given the high prevalence of these emotional symptoms following injury. It is also important to understand whether these relationships are affected by TBI severity, and the validity of test performance and symptom report. This meta-analysis was conducted to investigate whether these symptoms are associated with cognitive test performance alterations in adults with a TBI. This meta-analysis was prospectively registered on the PROSPERO International Prospective Register of Systematic Reviews website (registration number: CRD42018089194). The electronic databases Medline, PsycINFO, and CINAHL were searched for journal articles published up until May 2020. In total, 61 studies were included, which enabled calculation of pooled effect sizes for the cognitive domains of immediate memory (verbal and visual), recent memory (verbal and visual), attention, executive function, processing speed, and language. Depression had a small, negative relationship with most cognitive domains. These relationships remained, for the most part, when samples with mild TBI (mTBI)-only were analysed separately, but not for samples with more severe TBI (sTBI)-only. A similar pattern of results was found in the anxiety analysis. PTSD had a small, negative relationship with verbal memory, in samples with mTBI-only. No data were available for the PTSD analysis with sTBI samples. Moderator analyses indicated that the relationships between emotional symptoms and cognitive test performance may be impacted to some degree by exclusion of participants with atypical performance on performance validity tests (PVTs) or symptom validity tests (SVTs), however there were small study numbers and changes in effect size were not statistically significant. These findings are useful in synthesising what is currently known about the relationship between cognitive test performance and emotional symptoms in adults with TBI, demonstrating significant, albeit small, relationships between emotional symptoms and cognitive test performance in multiple domains, in non-military samples. Some of these relationships appeared to be mildly impacted by controlling for performance validity or symptom validity, however this was based on the relatively few studies using validity tests. More research including PVTs and SVTs whilst examining the relationship between emotional symptoms and cognitive outcomes is needed.


Asunto(s)
Lesiones Traumáticas del Encéfalo , Trastornos por Estrés Postraumático , Adulto , Humanos , Trastornos por Estrés Postraumático/epidemiología , Depresión/etiología , Revisiones Sistemáticas como Asunto , Lesiones Traumáticas del Encéfalo/complicaciones , Lesiones Traumáticas del Encéfalo/psicología , Cognición , Pruebas Neuropsicológicas , Ansiedad/etiología
3.
Neuropsychol Rev ; 32(4): 736-757, 2022 12.
Artículo en Inglés | MEDLINE | ID: mdl-34398435

RESUMEN

While a significant proportion of the population suffer from migraine, the existing research literature does not provide a clear indication as to whether migraineurs experience objective cognitive deficits outside of acute migraine attacks. This meta-analysis was conducted to investigate which cognitive domains if any were affected by migraine, by synthesising the existing research quantitatively. The meta-analysis was prospectively registered with the PROSPERO International prospective register of systematic reviews (registration no.: CRD42019134138). A search of the electronic databases PubMed, Ovid MEDLINE, and PsycINFO was conducted for journal articles published between January 1980 and January 2020. Seventeen studies met the inclusion criteria, allowing for the calculation of pooled effect sizes between migraineurs (with and without aura) and healthy controls in the several cognitive domains. During the interictal period, migraineurs demonstrated a moderate, negative effect on complex attention immediate and delayed memory, spatial cognition, and executive functioning. This effect was not attributable to migraine history, attack frequency, or participant age. However, the lack of performance validity testing, and limited data on mood symptomatology and migraine medication use in the included studies may be confounds potentially overestimating the magnitude of effect. Comparison with a clinical control group, which may have accounted for some these extraneous variables, was unable to be conducted. Recommendations for comprehensive future neuropsychological research are provided.


Asunto(s)
Trastornos del Conocimiento , Trastornos Migrañosos , Humanos , Revisiones Sistemáticas como Asunto , Trastornos del Conocimiento/psicología , Trastornos Migrañosos/complicaciones , Trastornos Migrañosos/psicología , Función Ejecutiva , Cognición
4.
Am J Orthopsychiatry ; 91(3): 412-422, 2021.
Artículo en Inglés | MEDLINE | ID: mdl-34138630

RESUMEN

This report summarizes what is known about the psychological impact of the COVID-19 pandemic and proposes ways for psychology organizations to engage in addressing pandemic-related challenges. A stress and coping framework is used to describe key factors that account for mental health difficulties resulting from the stress of pandemics including the pandemic course, political leadership and public response, cumulative stressors, risk and protective factors, and coping strategies. Psychology organizations could do much to provide help particularly to vulnerable healthcare and frontline workers, the elderly, and the socially isolated. They could offer clinical services and design prevention programs, train non-professional community workers to provide mental health first aid, assist NGO's and political leaders, and translate basic research on psychological factors that influence acceptance of public health measures. The pandemic occurs at a time of advanced connectivity that provides an opportunity for (a) scientific information exchange, (b) alleviation of distress of social isolation, but also (c) infodemic, unprecedented spread of hoaxes and online incitements to non-compliance with preventative measures. Psychology's role is not limited to addressing mental health needs but also includes promoting adjustment to changes in the economy, education and employment, and developing effective communication strategies that encourage acceptance of public health measures. (PsycInfo Database Record (c) 2021 APA, all rights reserved).


Asunto(s)
Adaptación Psicológica , COVID-19/psicología , Trastornos Mentales/psicología , Aceptación de la Atención de Salud , Estrés Psicológico/psicología , Personal de Salud/psicología , Humanos , Trastornos Mentales/diagnóstico , Política , Salud Pública , Aislamiento Social
5.
J Clin Exp Neuropsychol ; 43(5): 449-468, 2021 07.
Artículo en Inglés | MEDLINE | ID: mdl-34107843

RESUMEN

Topographical disorientation is the impairment or inability to successfully navigate in three-dimensional space. Differing topographical disorientation syndromes have been associated with distinct lesion sites in the acquired brain injury (ABI) literature. This meta-analysis attempted to investigate the relationship between lesion location and dysfunctions in specific navigational abilities resulting in topographical disorientation in individuals with ABI, as measured by their performance on experimental and neuropsychological tests. It was expected that focal lesions would be associated with a specific navigational deficit in one ability, with relative sparing of other navigational abilities. Twenty-six papers met the inclusion criteria for the analysis. Results indicated that ABI populations performed worse on all measures of navigation, with moderate to large effect sizes. Dysfunctions in three core navigational skills were consistent with the available lesion studies: a feature/landmark processing unit, a spatial processing unit, and a spatial/feature binding and associative learning unit. A sequential processing model was created to attempt to best represent the transfer of information between these units and the process by which navigational knowledge is generated. The model was then used to assess the validity of existing models of navigation and topographical disorientation.


Asunto(s)
Lesiones Encefálicas , Navegación Espacial , Procesamiento Espacial , Confusión , Humanos , Pruebas Neuropsicológicas , Percepción Espacial , Síndrome
6.
Psychol Aging ; 34(7): 954-977, 2019 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31682146

RESUMEN

This meta-analysis examined how performance on various cognitive domains of neuropsychological functioning can contribute to predicting progression to dementia from mild cognitive impairment (MCI) or subjective memory complaints. Studies performed between the years of 1997 and 2018 were identified through a search of the electronic databases Medline and PsycINFO. Data from the articles identified were pooled to determine standardized mean differences, calculated as Hedges g, using a random-effects model. Twenty-four studies were included in the analysis. The majority of studies examined the progression of amnestic mild cognitive impairment (aMCI) to Alzheimer's disease (AD). Nonprogressors performed significantly better than did progressors in the domains of divided attention, executive function, expressive language, immediate recall, processing speed, delayed recall, visuospatial/constructional ability, working memory, and sustained attention. These findings indicate that individuals with MCI or subjective memory complaints who do not progress to dementia, perform better at baseline as compared with individuals that progress to dementia on a range of neuropsychological measures, and lends further support to the contention that neuropsychological assessment can make important contributions to predicting progression to dementia while individuals are still in the MCI or subjective memory complaint stage. (PsycINFO Database Record (c) 2019 APA, all rights reserved).


Asunto(s)
Enfermedad de Alzheimer/psicología , Disfunción Cognitiva/psicología , Demencia/etiología , Pruebas Neuropsicológicas/normas , Anciano , Demencia/patología , Progresión de la Enfermedad , Femenino , Humanos , Masculino
7.
Neuropsychol Rev ; 29(3): 288-312, 2019 09.
Artículo en Inglés | MEDLINE | ID: mdl-31129865

RESUMEN

A thorough understanding of the cognitive effects of corticosteroids is essential given their frequency of use. This meta-analysis was conducted to investigate the effects of corticosteroids on the various domains of cognitive functioning, grouped by duration of use. An electronic search of PsycInfo, Medline and Google Scholar was conducted for all journal articles published between January 1990 and May 2018. Twenty six studies were included enabling calculation of standardised mean difference (SMD) using a random effects model for the cognitive domains of divided attention, executive function, expressive language, immediate memory, processing speed, recent memory, sustained attention, very long term memory and working memory. Results revealed that corticosteroids had a modest, negative effect on executive function for acute users, recent memory for short term and chronic users, and very long term memory for acute users. Corticosteroids had a small, significant, positive effect on expressive language for short term users.


Asunto(s)
Corticoesteroides/administración & dosificación , Cognición/efectos de los fármacos , Atención , Función Ejecutiva , Humanos , Memoria , Pruebas Neuropsicológicas
8.
Arch Clin Neuropsychol ; 35(1): 31-45, 2019 Jan 24.
Artículo en Inglés | MEDLINE | ID: mdl-30668621

RESUMEN

OBJECTIVE: This study presents an updated meta-analysis replicating the study of (Stavro, K., Pelletier, J., & Potvin, S. (2013). Widespread and sustained cognitive deficits in alcoholism: A meta-analysis. Addiction Biology, 18, 203-213. doi:10.1111/j.1369-1600.2011.00418.x) regarding the cognitive functioning of alcoholics as a function of time abstinent. METHODS: A total of 34 studies (including a total of 2,786 participants) that met pre-determined inclusion and exclusion criteria were included in the analyses. The alcoholics were categorised into recently detoxified alcoholics (0-31 days sober), alcoholics 32-365 days sober and alcoholics >365 days sober consistent with the previous study. The current study employed more stringent control on the tests included in the analysis to include only those tasks described in contemporary neuropsychological test compendia. Forty-seven percent of the papers surveyed were not include in the previous meta-analysis. RESULTS: The results indicated that there was a diffuse and pervasive pattern of cognitive deficit among recently detoxified alcoholics and that these deficits, particularly with regard to memory functioning, persisted even in longer term abstinent alcoholics. This was inconsistent with the prior meta-analysis which contended that significant cognitive recovery was possible after as little as 1 year. CONCLUSION: The persisting cognitive deficits were noted across a wide range of cognitive functions, supporting the notion of a diffuse rather than a specific compromise of cognition in alcoholism following discontinuation, as measured using standardised neuropsychological tests. Limitations on the finding included the fact that it was a cross-sectional rather than a longitudinal analysis, was subject to heterogeneity of method, had low representation of females in the samples, and had fewer studies of long-term sober samples.


Asunto(s)
Abstinencia de Alcohol/psicología , Alcoholismo/psicología , Trastornos del Conocimiento/psicología , Adulto , Alcoholismo/complicaciones , Trastornos del Conocimiento/complicaciones , Estudios Transversales , Femenino , Humanos , Masculino , Memoria , Persona de Mediana Edad , Pruebas Neuropsicológicas , Templanza
9.
J Clin Exp Neuropsychol ; 41(1): 26-42, 2019 02.
Artículo en Inglés | MEDLINE | ID: mdl-30025491

RESUMEN

OBJECTIVES: The aim of this study was to compare the two most commonly prescribed classes of atypical antipsychotic medications (i.e., -pines and -dones) with regard to their effects on cognition in patients with schizophrenia. DATA SOURCES: Ovid Technologies web-based software was used to search the Medline and PsycINFO computerized databases to identify articles that met the inclusion criteria. REVIEW METHODS: The search was limited to papers published after 1990, written in English, employing human subjects, using atypical antipsychotics, using a within-subjects design or control group of patients with schizophrenia for comparisons, using participants aged from 18-65, and employing standardized neuropsychological measures. RESULTS: A total of 996 eligible studies were identified, and of these 19 were finally analyzed. Nine domains of cognitive functioning were assessed. The two groups of agents produced equivalent overall effects (-dones = .254 versus -pines = .202). The -pines were found to improve the domains of attention/working memory, executive functioning, fluency, nonverbal memory, processing speed, and verbal memory, each with a significant, small effect size. The -dones were found to improve attention/working memory, executive functioning, motor function, nonverbal memory, processing speed, and verbal memory, each with a significant, small effect size. Failsafe N was robust for all of the domains for the -pines, but only for the verbal memory domain for the -dones, suggesting that the significant findings for the other domains with the -dones are more tenuous. CONCLUSION: The results indicate that the agents were largely equivalent and that there was no clear evidence that the pattern of cognitive effects differed as a result of the agent applied. The effects themselves, while statistically significant, were small, indicating that some or all of the differences may be attributable to practice effects on the instruments employed.


Asunto(s)
Antipsicóticos/farmacología , Atención/efectos de los fármacos , Cognición/efectos de los fármacos , Esquizofrenia/tratamiento farmacológico , Antipsicóticos/uso terapéutico , Función Ejecutiva/efectos de los fármacos , Humanos , Memoria a Corto Plazo/efectos de los fármacos , Pruebas Neuropsicológicas , Psicología del Esquizofrénico
10.
Neuropsychiatr Dis Treat ; 14: 2531-2539, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30323601

RESUMEN

OBJECTIVES: Patients with Parkinson's disease (PD) present with a wide range of cognitive deficits. Cognitive impairment is recognized as an independent nonmotor aspect of the disorder and has a critical role in functional outcome and conversion into PD dementia. To date, everyday memory impairment in elderly patients with PD is underinvestigated and its relationship with executive dysfunction was not clearly explained. Our study aims at clarifying the neuropsychological pattern of everyday memory and executive deterioration in elderly patients with PD. METHODS: Forty nondemented PD patients (mean age 71.2 years; M:F = 29:11) and 30 well-matched controls (mean age 70.7 years; M:F = 15:15) were assessed on everyday memory (Rivermead Behavioral Memory Test [RBMT]) and executive functioning (Frontal Assessment Battery [FAB]) measures. Mann-Whitney U-tests (Bonferroni corrected) were used to compare groups on these measures and Spearman's rank correlations were performed to highlight their associations. RESULTS: PD patients performed worse than controls on recall for novel tasks and geographic recall (RMBT) as well as lexical fluency and mental flexibility (FAB). Particularly, spatial orientation depending on egocentric navigation seems to be altered in PD patients. The clinical group showed poorer performances than controls in mental flexibility, sensitivity to interference, and inhibitory control. Such measures were associated with immediate and delayed recall, picture recognition, prospective memory, and orientation tasks of everyday memory. CONCLUSION: Executive-type difficulties and memory-type difficulties have an impact on cognitive performances of elderly patients with PD. We recommend using the RBMT and the FAB as part of routinely neuropsychological battery for assessing PD patients.

11.
Neuropsychol Rev ; 28(1): 32-72, 2018 03.
Artículo en Inglés | MEDLINE | ID: mdl-29446012

RESUMEN

A thorough understanding of the cognitive effects of antidepressant medications is essential given their frequency of use. This meta-analysis was conducted to investigate whether antidepressants differentially affect the various domains of cognitive functioning for depressed and non-depressed participants. An electronic search of PsycInfo, Medline and Google Scholar was conducted for all journal articles published between January 1998 and January 2017. Thirty-three studies were included enabling calculation of Hedges' g using a random effects model for the cognitive domains of divided attention, executive function, expressive language, immediate memory, perceptual motor skills, processing speed, recent memory, sustained attention, visuospatial-constructional skills and working memory. Results revealed that overall, antidepressants have a modest, positive effect on divided attention, executive function, immediate memory, processing speed, recent memory and sustained attention for depressed participants. Selective serotonin reuptake inhibitors (SSRI's) were found to have the greatest positive effect on cognition for depressed participants, as compared to the other classes of antidepressants analysed. Antidepressants did not significantly affect cognitive function in non-depressed participants.


Asunto(s)
Antidepresivos/uso terapéutico , Cognición/efectos de los fármacos , Depresión/tratamiento farmacológico , Depresión/psicología , Nootrópicos/uso terapéutico , Humanos
12.
Clin Neuropsychol ; 32(3): 368-390, 2018 04.
Artículo en Inglés | MEDLINE | ID: mdl-29272971

RESUMEN

OBJECTIVE: Neuropsychological assessment (NPA) addresses important aspects of diagnosis, prognosis, treatment, and rehabilitation planning. This review set out to determine the impact of NPA on the adult patient's outcome, by examining how and whether NPA influences diagnostic decision-making and surgical planning, how NPA can be used to predict patient outcome, and how clients, referrers, and significant others perceive the value of NPA. METHOD: Eligible studies were selected according to pre-defined selection criteria and accessed via the electronic databases Medline and PsycInfo. RESULTS: Eighty-one studies were included, with 14 examining the influence of NPA on diagnosis, 62 in predicting outcomes, and 5 addressing the perceptions of NPA by users. The evidence was generally supportive of the value of NPA for its ability to increase the accuracy of diagnoses, to assist with decisions regarding surgical planning, to predict patient outcomes, and in its clinical benefit as reported by physicians and patients. CONCLUSION: The review demonstrated the benefit of NPA in assisting with diagnosis and prognosis, and showed positive findings with regard to consumer perceptions of NPA. The neuropsychological literature would materially benefit from high-quality randomized control trials of NPA to definitively demonstrate the efficacy of this measure in clinical management.


Asunto(s)
Toma de Decisiones , Trastornos Mentales/diagnóstico , Trastornos Mentales/psicología , Pruebas Neuropsicológicas/normas , Adulto , Humanos , Selección de Paciente , Pronóstico , Resultado del Tratamiento
13.
Arch Clin Neuropsychol ; 33(7): 901-911, 2018 Nov 01.
Artículo en Inglés | MEDLINE | ID: mdl-29244060

RESUMEN

OBJECTIVE: This study presents an updated meta-analysis of the effects of benzodiazepines on cognitive functioning in long-term, current users of these agents, those who have recently withdrawn and on those who have successfully abstained following withdrawal. The study represents an update of the previous meta-analyses published by our group. METHOD: A comprehensive search of the computerized databases Medline and PsycINFO was undertaken to identify studies that assessed the cognitive effects of benzodiazepines published up to 28 November 2016 (the date of the last update). Nineteen studies (eight studies published since the previous meta-analyses and 11 studies included in the previous studies) were included. RESULTS: The results of the analysis for current users revealed statistically significant, negative effects for the cognitive domains of working memory, processing speed, divided attention, visuoconstruction, recent memory, and expressive language. For those who had withdrawn and successfully abstained following withdrawal, deficits were observed for the domains of recent memory, processing speed, visuoconstruction, divided attention, working memory, and sustained attention. CONCLUSIONS: The results of the study are important in that they corroborate the mounting evidence that a range of neuropsychological functions are impaired as a result of long-term benzodiazepine use, and that these are likely to persist even following withdrawal. The findings highlight the residual neurocognitive compromise associated with long-term benzodiazepine therapy as well as the important clinical implications of these results.


Asunto(s)
Benzodiazepinas/efectos adversos , Trastornos del Conocimiento/inducido químicamente , Cognición/efectos de los fármacos , Aptitud , Atención/efectos de los fármacos , Benzodiazepinas/farmacología , Trastornos del Conocimiento/psicología , Humanos , Memoria a Corto Plazo/efectos de los fármacos , Pruebas Neuropsicológicas
14.
J Int Neuropsychol Soc ; 24(4): 405-415, 2018 04.
Artículo en Inglés | MEDLINE | ID: mdl-29081331

RESUMEN

BACKGROUND: Carbon monoxide (CO) poisoning is the leading cause of accidental poisoning worldwide. This study undertook a meta-analysis to examine differences in neuropsychological functioning in patients with CO poisoning as compared to healthy controls, and examined the longer-term neuropsychological effects of CO poisoning. METHODS: Studies performed between the years 1995 and 2016 were identified through a search of the electronic databases Medline and PsycInfo. Data from the papers identified were pooled to determine standard mean differences using a random-effects model. RESULTS: Ten studies were included in the analysis, with healthy controls performing significantly better than CO poisoned participants on the domains of divided attention, immediate memory, and processing speed. No statistically significant differences were found for sustained attention, recent memory, working memory, visuospatial/constructional ability, and expressive language. Performance by participants with CO poisoning for the domains of sustained attention, recent memory, visuospatial/constructional abilities, and working memory significantly improved over time after initial exposure, demonstrating recovery of these functions over time. No statistically significant differences were evident for divided attention or expressive language. CONCLUSIONS: This evidence indicates that healthy controls perform better than do individuals with CO poisoning on a range of neuropsychological domains; however, it also indicates that performance in some domains does improve over time. (JINS, 2018, 24, 405-415).


Asunto(s)
Intoxicación por Monóxido de Carbono/complicaciones , Disfunción Cognitiva/inducido químicamente , Disfunción Cognitiva/fisiopatología , Humanos
15.
Psychoneuroendocrinology ; 87: 9-19, 2018 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-29032324

RESUMEN

Deficits in social cognition are pervasive and characteristic of neurodevelopmental disorders (NDDs). Clinical trials of intranasal oxytocin (IN-OT) to improve social cognition have yielded inconclusive results. The current study is a meta-analysis of randomized controlled trials (RCTs) considering the effect of IN-OT on social cognitive domains across a range of NDDs. Medline, PsychINFO and Scopus were searched for RCTs published through to July 25, 2017. Seventeen studies met inclusion criteria, comprising 466 participants with a NDD. Meta-analysis using a random-effects model, revealed that IN-OT had no significant effect on emotion recognition (Hedges' g=0.08), a moderate but non-significant effect on empathy (Hedges' g=0.49), and a small, significant effect on theory of mind (ToM) (Hedges' g=0.21). Meta-regression indicated that the effect of IN-OT on social cognition was not moderated by the diagnosis or age of participants, or the dose or frequency of IN-OT administration. The results highlight a need for more well-designed RCTs, as it remains difficult to draw conclusions about the potential for IN-OT to improve social cognition in NDDs. The promise of IN-OT should be considered tentative.


Asunto(s)
Cognición/efectos de los fármacos , Trastornos del Neurodesarrollo/fisiopatología , Oxitocina/farmacología , Administración Intranasal/métodos , Administración Intranasal/psicología , Emociones/efectos de los fármacos , Empatía/efectos de los fármacos , Humanos , Relaciones Interpersonales , Oxitocina/administración & dosificación , Oxitocina/fisiología , Conducta Social , Habilidades Sociales , Teoría de la Mente/efectos de los fármacos
16.
Arch Clin Neuropsychol ; 31(2): 186-93, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26743325

RESUMEN

This meta-analysis set out to ascertain the cognitive function of obstructive sleep apnea (OSA) patients as measured through objective neuropsychological tests. The meta-analysis investigated the cognitive functioning of these patients prior to them receiving any treatment such as continuous positive airway pressure (CPAP). A total of 19 studies met the study inclusion criteria. Results revealed statistically significant negative effect sizes in the cognitive domains of non-verbal memory, concept formation, psychomotor speed, construction, executive functioning, perception, motor control and performance, attention, speed of processing, working and verbal memory, verbal functioning and verbal reasoning. The clinical implication of these results, the possible causal mechanisms of the cognitive impairments and the implication of these for future research were each discussed. Despite a number of important limitations, the analysis highlights the need for clinicians to comprehensively explore complaints about sleep disturbance, particularly OSA, in all clinical assessments to ensure control for this important confounder in order to ensure appropriate attribution of the source of any observed cognitive compromise.


Asunto(s)
Trastornos del Conocimiento/complicaciones , Trastornos del Conocimiento/psicología , Apnea Obstructiva del Sueño/complicaciones , Apnea Obstructiva del Sueño/psicología , Femenino , Humanos , Masculino , Pruebas Neuropsicológicas
17.
J Clin Exp Neuropsychol ; 38(4): 371-80, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-26678400

RESUMEN

INTRODUCTION: This study investigated proactive and retroactive interference effects between the Wechsler Memory Scale-Fourth Edition (WMS-IV) using the flexible approach, and the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV). METHOD: One hundred and eighty nonclinical participants were assigned to a four (visual interference, verbal interference, visual and verbal interference, vs. no interference) by two (retroactive vs. proactive) between-subjects design. The administration order of the tests was counterbalanced (i.e., administration of the WAIS-IV prior to the WMS-IV, and the WAIS-IV administered during the delay interval of the WMS-IV). RESULTS: The WAIS-IV produced significant retroactive interference effects on the WMS-IV; however, no proactive interference effect was observed. The retroactive interference effect was dependent on material specificity. CONCLUSIONS: The results indicate that material presented within the delay of the WMS-IV can have a significant effect on subsequent delayed recall. Clinicians should carefully consider the effects associated with carry-over effects of these tests when using them in combination.


Asunto(s)
Inhibición Psicológica , Inteligencia/fisiología , Memoria a Corto Plazo/fisiología , Reconocimiento en Psicología/fisiología , Escalas de Wechsler , Adolescente , Adulto , Análisis de Varianza , Femenino , Humanos , Vida Independiente , Masculino , Recuerdo Mental/fisiología , Persona de Mediana Edad , Pruebas Neuropsicológicas , Estimulación Luminosa , Escalas de Valoración Psiquiátrica , Tiempo de Reacción/fisiología , Encuestas y Cuestionarios , Adulto Joven
18.
Cogn Emot ; 30(8): 1504-1511, 2016 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-26264817

RESUMEN

Shame and guilt are closely related self-conscious emotions of negative affect that give rise to divergent self-regulatory and motivational behaviours. While guilt-proneness has demonstrated positive relationships with self-report measures of empathy and adaptive interpersonal functioning, shame-proneness tends to be unrelated or inversely related to empathy and is associated with interpersonal difficulties. At present, no research has examined relationships between shame and guilt-proneness with facial emotion recognition ability. Participants (N = 363) completed measures of shame and guilt-proneness along with a facial emotion recognition task which assessed the ability to identify displays of anger, sadness, happiness, fear, disgust, and shame. Guilt-proneness was consistently positively associated with facial emotion recognition ability. In contrast, shame-proneness was unrelated to capacity for facial emotion recognition. Findings provide support for theory arguing that guilt and empathy operate synergistically and may also help explain the inverse relationship between guilt-proneness and propensity for aggressive behaviour.

19.
J Clin Exp Neuropsychol ; 36(7): 691-700, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24931450

RESUMEN

The "z-drugs" zopiclone, zolpidem, eszopiclone, and zaleplon were introduced in the 1980s for the treatment of insomnia, as it was observed that the side effect profile associated with these medications were more benign than those related to the benzodiazepines. This meta-analysis set out to ascertain which domains of cognitive function, if any, were affected by the ingestion of these medications. A total of 20 studies met the study inclusion criteria. Results revealed medium effect sizes for zopiclone and zolpidem on measures of verbal memory. An additional medium effect size was observed for zolpidem on attention. Finally, smaller effect sizes were observed for zolpidem speed of processing and for zopiclone on working memory. It is clear from these data that the use of a single dose of the z-drugs in healthy adults as measured in the morning following the exposure does produce a specific rather than a generalized negative effect on cognitive function. However, there were only enough studies to evaluate the individual cognitive effects of the zolpidem and zopiclone medications; the specific effects of zaleplon and eszopiclone cannot be ascertained because only one study met the inclusion and exclusion criteria for the review.


Asunto(s)
Acetamidas/efectos adversos , Atención/efectos de los fármacos , Compuestos de Azabiciclo/efectos adversos , Hipnóticos y Sedantes/efectos adversos , Memoria/efectos de los fármacos , Piperazinas/efectos adversos , Desempeño Psicomotor/efectos de los fármacos , Piridinas/efectos adversos , Pirimidinas/efectos adversos , Eszopiclona , Humanos , Zolpidem
20.
Clin Neuropsychol ; 28(3): 486-504, 2014.
Artículo en Inglés | MEDLINE | ID: mdl-24606169

RESUMEN

The Boston Naming Test (BNT) (Kaplan, Goodglass, & Weintraub, 1983) is the most commonly used test of confrontation naming in neuropsychology (Rabin, Barr, & Burton, 2005). However, there are significant criticisms of the BNT which suggest that it might not be the assessment measure of choice. These criticisms are that the BNT has poor psychometric properties, is not adequately standardized, and has inadequate norms. It is further suggested that when considered in the context of contemporary conceptualizations of the neuropsychology of naming, the BNT does not adequately capture the processes known to be required for successful naming, and does not sample widely enough from the content domain of "naming". These criticisms suggest that the BNT is flawed as a measure of naming, and are discussed in detail in this review. Other stand-alone visual confrontation naming tasks are reviewed to evaluate whether any might be viable substitutes for the BNT in clinical neuropsychology. The Naming Test from the Neuropsychological Assessment Battery (Stern & White, 2009) was identified as a possible alternative to the BNT, however, neither of these tests was designed with reference to models of the neuropsychology of naming, and development of a new test of naming is indicated.


Asunto(s)
Pruebas Neuropsicológicas/normas , Psicometría , Humanos
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