Synthesis, X-Ray Crystal Structure of Oxidovanadium(V) Complex Derived from 4-Bromo-N’-(2-hydroxybenzylidene) benzohydrazide with Catalytic Epoxidation Property.

A new oxidovanadium(V) complex, [VOL(OCH3)(CH3OH)], where H2L = 4-bromo-N'-(2-hydroxybenzylidene)benzohydrazide, has been synthesized and fully characterized on the basis of CHN elemental analysis, FT-IR, UV-Vis, 1H and 13C NMR spectroscopy. Structures of the free hydrazone and the complex were further characterized by single crystal X-ray diffraction, which indicates that the V atom in the complex adopts octahedral coordination, and the hydrazone ligand behaves as a tridentate ligand. The catalytic epoxidation property of the complex was investigated.

N’-(2-Hydroxybenzylidene)-3-Methylbenzohydrazide and its Copper(II) Complex: Syntheses, Characterization, Crystal Structures and Biological Activity.

The hydrazone compound N'-(2-hydroxybenzylidene)-3-methylbenzohydrazide (H2L) was prepared. With H2L and copper acetate a new copper complex [Cu(HL)(NCS)]·CH3OH was synthesized. Both the hydrazone and the copper complex were characterized by physico-chemical methods and single crystal X-ray diffraction techniques. The complex is a thiocyanato-coordinated copper(II) species. The Cu atom in the complex is in square planar geometry. The complex is a promising urease inhibitor.

Syntheses, Crystal Structures and Catalytic Property of Oxidovanadium(V) Complexes Derived from Tridentate Hydrazone Ligands.

Two new ethyl maltolato coordinated mononuclear oxidovanadium(V) complexes [VOLa(emt)]·DMF (1) and [VOLb(emt)] (2), where H2La = N'-(4-bromo-2-hydroxybenzylidene)-3-hydroxybenzohydrazide, H2Lb = N'-(4-bromo-2-hydroxybenzylidene)benzohydrazide, Hemt = ethyl maltol, have been synthesized and characterized on the basis of CHN elemental analysis, FT-IR and UV-Vis spectroscopy and powder XRD analysis. Structures of the complexes were further characterized by single crystal X-ray diffraction, which indicated that the V atoms in the complexes adopt octahedral coordination. The hydrazones behave as NOO tridentate ligands. The catalytic epoxidation properties on cyclooctene of the complexes were investigated.

Synthesis, inhibitory activity and molecular docking studies of two Cu(II) complexes against Helicobacter pylori urease.

Two mononuclear copper(II) complexes, [Cu(C(15)H(16)NO(2))(2)] (1) and [Cu(C(6)H(9)N(2)O(4))(2)·3H(2)O] (2·3H(2)O), were synthesised and structurally characterised by single-crystal X-ray analysis. The copper(II) atom adopts a square-planar environment in complex 1, while the geometry in 2·3H(2)O could be described as the distorted square pyramidal. Complexes 1 and 2·3H(2)O were evaluated for their inhibitory activities against Helicobacter pylori (H. pylori) urease in vitro. They both were found to have strong inhibitory activities against H. pylori urease comparable to that of acetohydroxamic acid (AHA). A docking simulation was performed to position 2 into the H. pylori urease active site to determine the probable binding conformation.

Aqua-bis(5-methyl-pyrazine-2-carboxyl-ato)zinc(II) trihydrate.

In the title compound, [Zn(C(6)H(5)N(2)O(2))(2)(H(2)O)]·3H(2)O, the Zn(II) centre is five-coordinated by two O,N-bidentate Schiff base ligands and one O atom from a water mol-ecule in a slightly distorted square-pyramidal geometry. In the crystal, the complex and uncoordinated water mol-ecules are linked by O-H⋯O, O-H⋯N and C-H⋯O hydrogen bonds, forming a three-dimensional network.

Bis{2-[(1H-pyrrol-2-yl)methyl-imino-meth-yl]phenolato-κN,O}zinc(II).

In the title compound, [Zn(C(12)H(11)N(2)O)(2)], the Zn(II) atom, lying on an inversion center, is coordinated by two O atoms and two N atoms from two salicylal Schiff base ligands in a distorted square-planar geometry. A three-dimensional network is formed by inter-molecular C-H⋯N hydrogen bonds and C-H⋯π contacts.

2,4-Disulfanyl-6-[(E)-(2-sulfanylbenz-yl)imino-meth-yl]phenol.

In the title compound, C(14)H(13)NOS(3), the dihedral angle between the benzene rings is 73.26 (5)° and an intra-molecular O-H⋯N hydrogen bond occurs.

Diaqua-bis[2-(4-bromo-phen-yl)acetato]bis-(N,N-dimethyl-pyridin-4-amine)copper(II).

In the title compound, [Cu(C(8)H(6)BrO(2))(2)(C(7)H(10)N(2))(2)(H(2)O)(2)], the Cu(II) atom (site symmetry ) adopts a Jahn-Teller-distorted trans-CuN(2)O(4) octa-hedral coordination, with the aqua O atoms in axially extended sites. An intra-molecular O-H⋯O hydrogen bond helps to establish the conformation and an inter-molecular O-H⋯O hydrogen bond is seen in the crystal packing.

Bis(2-cyclo-hexyl-imino-methyl-4,6-dihydro-seleno-phenolato)cobalt(II) acetonitrile solvate.

In the title compound, [Co(C(13)H(16)NOSe(2))(2)]·CH(3)CN, the Co(II) atom is four-coordinated by two N,O-bidentate Schiff base ligands, resulting in a distorted tetra-hedral coordination for the metal ion.

Effect of glabridin from Glycyrrhiza glabra on learning and memory in mice.

Glabridin was isolated from the roots of Glycyrrhiza glabra and its effects on cognitive functions and cholinesterase activity were investigated in mice. Glabridin (1, 2 and 4 mg kg (-1), P. O.) and piracetam (400 mg kg (-1), i. p.), a clinically used nootropic agent, were administered daily for 3 successive days to different groups of mice. The higher doses (2 and 4 mg kg (-1), P. O.) of glabridin and piracetam significantly antagonized the amnesia induced by scopolamine (0.5 mg kg (-1), I. P.) in both the elevated plus maze test and passive avoidance test. Furthermore, glabridin (2 and 4 mg kg (-1), P. O.) and metrifonate (50 mg kg (-1), I. P.), used as a standard drug, both remarkably reduced the brain cholinesterase activity in mice compared to the control group. Therefore, glabridin appears to be a promising candidate for memory improvement and it will be worthwhile to explore the potential of glabridin in the management of Alzheimer patients.

Ethyl 3-(2,4-difluoro-phen-oxy)-2-(4-methoxy-phen-yl)acrylate.

In the title mol-ecule, C(18)H(16)F(2)O(4), the two benzene rings form a dihedral angle of 55.2 (2)°. In the crystal structure, weak inter-molecular C-H⋯O hydrogen bonds link the mol-ecules into chains propagating along the c axis.

Ethyl 2-(4-chloro-phen-yl)-3-(3,5-dimethoxy-phen-oxy)acrylate.

The title compound, C(19)H(19)ClO(5), displays a dihedral angle of 74.7 (3)° between the mean planes of the 4-chloro-phenyl and phenol rings.

[Studies on flavonoids extraction technology from Glycyrrhiza inflata and their bacteriostatic activities].

OBJECTIVE: To study the extraction technique for the flavonoids from Glycyrrhiza inflata and their bacteriostatic bioactivities. METHODS: It was investigated about comparison of extraction methods such as ultrasonic-assisted extraction (UAE), enzymatic extraction (EE), whisk extraction (WE) and repeat freeze-dissolve extraction (FDE). The UAE conditions were optimized by orthogonal array. The bacteriostatic effect was studied using doubling dilution. RESULTS: The UAE was the most effective method and the optimal UAE conditions were adding 20-fold ethanol (30% v/v), extracting for two times, 20 min each time. Futhermore, the minimal inhibitory concentrations (MIC) of the flavonoids against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis were 0.03125, 0.03125, 0.125, 0.03125 mg/ml respectively. CONCLUSION: UAE is suitable for fast and effective extraction of flavonoids. The flavonoids have obvious bacteriostatic bioactivities against microorganisms mentioned above.