1.
J Med Chem
; 20(11): 1511-6, 1977 Nov.
Artículo
en Inglés
| MEDLINE
| ID: mdl-915916
RESUMEN
Synthesis of 1-[2-(arylalkyl)-2-phenylethyl]-1H-imidazoles was accomplished starting from the corresponding phenylacetonitriles. Via successive alkylation, conversion to the corresponding ester, and sodium borohydride-lithium iodide reduction, beta-phenylalcanols were obtained. These alcohols were mesylated and then refluxed with imidazole in dimethylformamide to yield the title compounds, which were active in vitro against dermatophytes, yeasts, other fungi, and gram-positive bacteria. Some were also active in vivo against Candida albicans.
Asunto(s)
Antifúngicos/síntesis química , Imidazoles/síntesis química , Animales , Antifúngicos/uso terapéutico , Candidiasis/tratamiento farmacológico , Cobayas , Imidazoles/farmacología , Imidazoles/uso terapéutico , Pruebas de Sensibilidad Microbiana
2.
J Med Chem
; 20(11): 1516-20, 1977 Nov.
Artículo
en Inglés
| MEDLINE
| ID: mdl-915917