Pericardial Adipose Tissue Thrombospondin-1 Associates With Antiangiogenesis in Ischemic Heart Disease.

Accumulation of ectopic pericardial adipose tissue has been associated with cardiovascular complications which, in part, may relate to adipose-derived factors that regulate vascular responses and angiogenesis. We sought to characterize adipose tissue microvascular angiogenic capacity in subjects who underwent elective cardiac surgeries including aortic, valvular, and coronary artery bypass grafting. Pericardial adipose tissue was collected intraoperatively and examined for angiogenic capacity. Capillary sprouting was significantly blunted (twofold, p <0.001) in subjects with coronary artery disease (CAD) (age 60 ± 9 years, body mass index [BMI] 32 ± 4 kg/m2, low-density lipoprotein cholesterol [LDL-C] 95 ± 46 mg/100 ml, n = 29) compared with age-, BMI-, and LDL-C matched subjects without angiographic obstructive CAD (age 59 ± 10 y, BMI 35 ± 9 kg/m2, LDL-C 101 ± 40 mg/100 ml, n = 12). For potential mechanistic insight, we performed mRNA expression analyses using quantitative real-time polymerase chain reaction and observed no significant differences in pericardial fat gene expression of proangiogenic mediators vascular endothelial growth factor-A (VEGF-A), fibroblast growth factor-2 (FGF-2), and angiopoietin-1 (angpt1), or anti-angiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and endostatin. In contrast, mRNA expression of anti-angiogenic thrombospondin-1 (TSP-1) was significantly upregulated (twofold, p = 0.008) in CAD compared with non-CAD subjects, which was confirmed by protein western-immunoblot analysis. TSP-1 gene knockdown using short hairpin RNA lentiviral delivery significantly improved angiogenic deficiency in CAD (p <0.05). In conclusion, pericardial fat in subjects with CAD may be associated with an antiangiogenic profile linked to functional defects in vascularization capacity. Local paracrine actions of TSP-1 in adipose depots surrounding the heart may play a role in mechanisms of ischemic heart disease.

The postnatal testosterone rebound in first-time fathers and the quality and quantity of paternal care.

In human males, testosterone (T) decreases in the period following the birth of offspring. This decline has been widely interpreted as a facultative neuroendocrine response that facilitates parenting effort. Conversely, research on if (or when) this decline in T would be followed by an eventual recovery and subsequent shift away from parenting effort is lacking. In a U.S. community sample of 225 males transitioning to first-time fatherhood, we measured T at three occasions: third trimester, infant 3 months postnatal, and infant 9-10 months postnatal. Using a piecewise latent growth curve model (GCM), we detected a T rebound from when infants were 3 months old to when infants were 9-10 months old. The slope of this rebound was able to predict paternal care using two distinct measures: (a) an experience sampling method (ESM) that gathered data on paternal time allocation over the course of the study period and (b) independent coders rating fathers for the quality of paternal care during a structured task designed to elicit an infant fear response. As predicted, the more accelerated one's T rebound (slope), the less time fathers invested in their infants across the study period. However, we found a positive relationship between T rebound and quality of paternal care during a challenging activity. Discussion will focus on nuanced reasons that contribute to these findings as well as speculate on the ultimate function of a human paternal T rebound.

Life History Orientation Predicts COVID-19 Precautions and Projected Behaviors.

The ongoing Coronavirus disease (COVID-19) pandemic has had a devastating impact worldwide. It is unclear as to what one expects during the "post-peak" and "post-pandemic" periods in terms of: (1) continued adherence to precautionary measures (e.g., wearing a mask) and (2) behaviors during these periods pertaining to widespread (anticipated) medical solutions that can buffer subsequent waves (e.g., vaccination and donating plasma). In this study, we examine predictors of individual differences in attitudes and behaviors with regard to the COVID-19 pandemic and the months moving forward. Of the factors that contribute to how one might navigate the pandemic - a source of elevated environmental threat - life history orientation may play a crucial role. In this study, participants (n = 209) indicated their agreement with items on attitudes toward COVID-19 precautions and medical solutions that can buffer subsequent waves. In all models, we found significant positive relationships between one's slow life history orientation and their self-reported adherence to precautions and endorsement of medical solutions. This effect was detectable even after controlling for factors related to political conservatism and personal experience with deleterious events as a result of the pandemic. Discussion includes reflection on the main finding, demographic variables, as well as the relationships uncovered among the modeled covariates (e.g., social conservatism, political conservatism).