Tuberculosis Extrapulmonar como Linfopatía Cervical: Revisión Sistemática y Presentación de Caso Clínico

La tuberculosis es una infección bacteriana causada por Mycobacterium tuberculosis que afecta a millones de personas en todo el mundo. Aunque principalmente se manifiesta en los pulmones, también puede afectar otras partes del cuerpo, como la regiónes de la cabeza y el cuello. Aunque es poco común, se han reportado casos de tuberculosis en glándulas parótidas, tonsilas palatinas y seno piriforme. La forma más común de tuberculosis extrapulmonar en esta región es la linfadenopatía superficial, que afecta principalmente los nódulos linfáticos del territorio cervical anterior. Los linfonodos afectados por tuberculosis presentan características específicas en la ecografía, lo que puede ayudar en el diagnóstico. El diagnóstico de tuberculosis extrapulmonar se realiza mediante pruebas como la citología por aspiración con aguja fina (PAAF) o la reacción en cadena de la polimerasa (PCR). Estas pruebas permiten detectar la presencia de Mycobacterium tuberculosis en los tejidos afectados. El tratamiento de la tuberculosis implica el uso de antibióticos antituberculosos durante un periodo prolongado. Es importante seguir el tratamiento completo para asegurar la erradicación de las bacterias y prevenir la recurrencia de la enfermedad. En este artículo, se presenta una revisión sistemática de la literatura de tuberculosis extrapulmonar en la región de la cabeza y cuello y un caso de un paciente sexo masculino de 81 años de edad, que se presentó con un aumento de volumen submandibular izquierdo de 3 semanas de evolución, con hipótesis diagnóstica de submaxilitis idiopática. Presentaba múltiples adenopatías supraclaviculares, mediastínicas e hiliares, y en conjunto a scanner, biopsias, cultivos y test dio resultados positivos para tuberculosis que se manifestó de forma extrapulmonar.

Tuberculosis is a bacterial infection caused by Mycobacterium tuberculosis that affects millions of people around the world. Although it manifests primarily in the lungs, it can also affect other parts of the body, such as the head and neck regions. Although rare, cases of tuberculosis in the parotid glands, palatine tonsils, and piriform sinus have been reported. The most common form of extrapulmonary tuberculosis in this region is superficial lymphadenopathy, which mainly affects the nodules of the anterior cervical area. Lymph nodes affected by tuberculosis present specific characteristics on ultrasound, which can help in diagnosis. The diagnosis of extrapulmonary tuberculosis is made through tests such as fine needle aspiration cytology (FNAC) or polymerase chain reaction (PCR), which allow the presence of Mycobacterium tuberculosis in the affected tissues to be detected. Treatment of tuberculosis involves the use of anti-tuberculosis antibiotics for long periods of time. It is important to follow the complete treatment to ensure the eradication of bacteria and prevent recurrence of the disease. In this article, we present a systematic review of the literature on extrapulmonary tuberculosis in the head and neck region and case of an 81-year-old male patient, who presented with a 3-week increase in left submandibular volume with a diagnostic hypothesis of idiopathic submaxilitis. The patient had multiple supraclavicular, mediastinal and hilar lymphadenopathy; following scan, biopsies, and cultures, the patient tested positive for tuberculosis that manifested extrapulmonarily.

Resultados funcionales en el tratamiento del prolapso rectal

Introducción: El prolapso rectal es una entidad clínica poco frecuente, habitualmente acompañada de otras alteraciones del piso pélvico, con un impacto negativo en la calidad de vida. Existen pocos modelos de calidad de vida adaptados a nuestra realidad. Uno de ellos es el EQ-D5, adaptada por Olivares-Tirado. Objetivos: evaluar la calidad de vida y los resultados funcionales de la cirugía de prolapso entre 2015 y 2021 y correlacionarlos con las distintas técnicas abdominales. Material y Métodos: Este es un estudio retrospectivo, observacional, transversal y de cohorte. Se pesquisaron 84 pacientes, se incluyeron 59. Para el análisis de la calidad de vida se utilizó la Encuesta EQ-D5. Para complementar el estudio se midió el Cleveland Clinic Incontinence Score y el Constipation Scoring System. Resultados: Hubo cambios significativos en todas las encuestas aplicadas a la mejoría en pre y postoperatorio, sin existir diferencias entre técnicas quirúrgicas, pero con menor índice de estadía postoperatoria en el grupo laparoscópico. Discusión: Existe una mejoría en la calidad de vida postoperatoria que se refleja en los índices obtenidos, independiente de la técnica quirúrgica, no obstante, esta se ve atenuada en pacientes recidivados, lo que se relaciona con la literatura, también sin encontrar diferencias entre las técnicas. Existe menos constipación postoperatoria en la técnica de rectopexia ventral. Conclusiones: Existe mejoría en la calidad de vida independiente de la técnica quirúrgica, sin cambios en pacientes recidivados. Ante ello, se debiera elegir la técnica más rápida y sencilla para el manejo, idealmente laparoscópica.

Background: Rectal prolapse is a rare clinical entity, usually accompanied by other pelvic floor disorders, with a negative impact on quality of life. There are few models of quality of life adapted to our reality. One of them is the EQ-D5, adapted by Olivares-Tirado. Objectives: To evaluate the quality of life and functional outcomes of rectal prolapse surgery between 2015 and 2021 and correlate them with the different abdominal techniques. Material and Methods: This is a retrospective, observational, cross-sectional and cohort study. A total of 84 patients were screened, 59 were included. The EQ-D5 Survey was used for the analysis of quality of life. To complement the study, the Cleveland Clinic Incontinence Score and the Constipation Scoring System were measured. Results: There were significant changes in all surveys applied to pre- and postoperative improvement, with no differences between surgical techniques, but with a lower rate of postoperative stay in the laparoscopic group. Discussion: There is an improvement in the postoperative quality of life that is reflected in the indices obtained, independent of the surgical technique, however, this is attenuated in recidivated patients, which is related to the literature, also without finding differences between the techniques. There is less postoperative constipation in the ventral rectopexy technique. Conclusions: There is improvement in the quality of life independent of the surgical technique, without changes in relapsed patients. Perhaps the fastest and easiest technique for handling should be chosen, ideally laparoscopic.

Use of semi-constrained total knee arthroplasty in gonarthrosis with collateral ligament insufficiency: Clinical and functional outcomes.

INTRODUCTION: Achieving stability in total knee arthroplasty (TKA) is crucial for long-term implant survival. In cases of severe deformity or ligament laxity, constrained implants may be required. Traditionally, increasing constraint involved intramedullary stems. However, there are intermediary alternatives, including employing a constrained polyethylene insert without stems, thereby avoiding complications related to them. The study aims to evaluate our experience with a non-modular constrained (NMC) implant in primary TKA. MATERIAL AND METHODS: We conducted a retrospective review of the clinical and radiographic outcomes of 108 non-stemmed primary TKAs performed at our institution between 2013 and 2021 in patients with at least 10° deformity or 10mm ligament laxity. Data included demographics, preoperative and postoperative deformities, clinical outcomes and revision rates. RESULTS: A total of 103 patients (108 knees) with a mean age of 74 were followed up for a minimum of 2 years. The mean postoperative range of motion was 105°/0°. The median Oxford Knee Score, Knee Society Score and Knee Society Function Score were 43.5, 92 and 90, respectively. 17 knees had varus deformity (mean tibiofemoral angle of 2.7°), and 87 knees had excessive valgus deformity (mean tibiofemoral angle of 15.1°). The remaining 4 knees had a neutral alignment. The mean postoperative tibiofemoral angle was 6.8°. The overall revision rate was 6.5% (7 patients): 3 deep periprosthetic infections, 2 patellar dislocations, 1 stiffness and 1 aseptic loosening. CONCLUSION: Our experience demonstrates favorable mid-term outcomes with the NMC implant, providing a safe alternative to stemmed implants in primary TKA, particularly in cases of severe deformity or ligament laxity.

Manejo abierto del Quiste pilonidal

Introducción: El quiste pilonidal es una condición crónica inflamatoria de la piel y el tejido subcutáneo sacrocoxígeo, con alta incidencia en jóvenes y sexo masculino. El manejo quirúrgico incluye técnicas abiertas y cerradas que utilizan colgajos. El objetivo es describir las características clínicas y quirúrgicas de pacientes operados de quiste pilonidal con técnica abiertas. Material y Método: Estudio tipo cohorte, retrospectivo, observacional y transversal. Se incluyeron todos los pacientes operados por quiste pilonidal utilizando técnicas abiertas en el Hospital Clínico de la Universidad de Chile entre 2013 y 2019. Se recolectaron características clínicas y quirúrgicas como tipo de técnica abierta, tiempo operatorio, tiempo de curaciones y cierre definitivo. Se aplicó estadística descriptiva. Resultados: Se registraron 250 pacientes diagnosticados de quiste pilonidal desde 2013, de los cuales se incluyeron 84,8% pacientes manejados con técnicas abiertas. 60,8% fueron de sexo masculino. El IMC promedio fue de 26,8 con un 24,5% de pacientes con obesidad. De ellos, 55,3% habían sido drenados en urgencias previamente y 9,6% eran recidivas. El tamaño promedio fue de 3,6 cm. Las técnicas abiertas empleadas fueron: marsupialización, destechamiento y McFee. El tiempo promedio de curaciones fue de 5,9 semanas y el cierre definitivo ocurre en promedio a las 10,4 semanas; 4,7% recidivaron. Conclusión. La cirugía del quiste pilonidal en nuestra serie corresponde en su mayoría a técnicas abiertas (marsupialización y destechamiento). El tiempo de curaciones, de cierre de la herida y del porcentaje de recidivas de los pacientes operados de quiste pilonidal es similar a lo reportado internacionalmente.

Introduction: The pilonidal cyst is a chronic inflammatory condition of the skin and subcutaneous sacrocoxige tissue, with high incidence in young people and male sex. Surgical management includes open and closed techniques which use flaps. The objective is to describe the clinical and surgical characteristics of patients operated on for pilonidal cyst with open technique. Material and Method: Cohort, retrospective, observational and cross-sectional study. We included all patients operated on for pilonidal cyst using open techniques at the Hospital Clinic University of Chile between 2013 and 2019. Clinical and surgical characteristics was collected, such as type of open technique, operative time, healing time and definitive closure. Descriptive statistics were applied. Results: There were 250 patients diagnosed with pilonidal cyst since 2013, of which 84.8% were patients managed with open techniques; 60.8% were male. The average BMI was 26.8 with 24.5% of patients with obesity. 55.3% had been drained in the emergency room previously and 9.6% were relapses. The average size was 3.6 cm. The open techniques used were marsupialization, unroofing and McFee. The average healing time was 5.9 weeks and definitive closure occurs on average at 10.4 weeks; 4.7% relapsed. Conclusion: Surgery of the pilonidal cyst in our series corresponds mostly to open techniques (marsupialization and unroofing). The healing time, wound closure and the percentage of recurrences of patients operated on for pilonidal cyst is similar to that reported internationally.

Análisis del manejo en tumores presacros en adultos: Experiencia de los últimos 15 años en el Hospital Clínico de la Universidad de Chile

Antecedentes: Los tumores presacros son entidades frecuentes con diferentes etiologías, sin un abordaje quirúrgico establecido, habiendo relativamente poca experiencia en el manejo y en el seguimiento y resultados postoperatorios. Objetivo: Reportar el resultado en forma descriptiva del manejo de este tipo de lesiones en el hospital clínico de la Universidad de Chile. Material y Método: Estudio observacional, descriptivo y de carácter retrospectivo, de serie de casos, analizando la base de datos de cirugías del Hospital clínico de la Universidad de Chile en los últimos 15 años, excluyendo a pacientes con tumores óseos y operados por otros equipos. Se utilizo estadística simple y descriptiva para el análisis. Resultados: Se operaron 23 pacientes en los últimos 15 años, 12 por vía transabdominal, 9 resuelto por vía abierta y 3 por vía laparoscópica. Los restantes 11 fueron resuelto con abordaje posterior, siendo el de kraske usado en todos los pacientes. El seguimiento promedio fue de 16 meses. 4 pacientes registraron recurrencia Conclusiones: Los tumores presacros representan un desafío en términos de diagnóstico y manejo quirúrgico, siendo el estudio preoperatorio con imágenes más examen físico, determinante en el manejo quirúrgico del mismo. Es de considerar abordajes transabdominales en aquellos tumores mayores de 10 cms y en aquellos que se sospeche, fuertemente, malignidad, lo que no contraindica la vía laparoscópica. En caso de abordaje posterior, siempre descartar lesiones incidentales de recto, por lo que el examen anorrectal intraoperatorio debería estar de regla.

Background: Presacral tumors are frequent entities with different etiologies, without an established surgical management or approach, having relatively little experience in management and follow-up and postoperative results. Objective: To report the result in a descriptive way of the management of this type of lesions in the Clinical Hospital of the University of Chile. Material and Method: Observational, descriptive and retrospective study of case series, analyzing the database of surgeries of the Clinical Hospital of the University of Chile in the last 15 years, excluding patients with bone tumors and operated by other units. Simple and descriptive statistics were used for the analysis. Results: 23 patients were operated on in the last 15 years, 12 transabdominally. 9 resolved by open fashion and 3 laparoscopically. The remaining 11 patients was resolved with posterior approach, being the kraske used in all patients. The average follow-up was 16 months with 4 patients showing recurrence. Conclusions: The presacral tumors represent a challenge in terms of diagnosis and surgical management, being the preoperative study with images plus physical examination, determinant in the surgical management of the same. We recommend considering transabdominal approaches in those tumors larger than 10 cm and in those that strongly suspect malignancy, which does not contraindicate the laparoscopic route. In case of subsequent management, never rule out incidental lesions of the rectum, so the intraoperatory anorectal examination should be the rule.

Isquemia anastomótica por bevacizumab. Casos clínicos

Objetivo: Presentar dos casos de isquemia anastomótica tardía por bevacizumab y compararlo con la literatura actual. Casos clínicos: Se exponen dos pacientes con cáncer de recto metastásico, con manejo neoadyuvante, quirúrgico y adyuvancia que incluye bevacizumab, que presentan complicaciones isquémicas anastomóticas, evidenciadas con endoscopia, imágenes más biopsias dirigidas, resolviéndose en forma quirúrgica y biopsiando sitios perianastomóticos con cambios isquémicos. Discusión: Existe evidencia en la literatura que reporta isquemias y filtraciones anastomóticas tardías con el uso de bevacizumab. Parece prudente considerar y sospechar en forma oportuna esta complicación, especialmente, en pacientes con factores de riesgo. Conclusiones: Se debe considerar eventos isquémicos en territorios quirúrgicos, al uso de Bevacizumab. Mayor hincapié en pacientes con factores de riesgo como malnutrición, irradiación o sexo masculino. Considerar estudio dirigido anastomótico previo al inicio de bevacizumab. Dar relevancia a los tiempos de suspensión y reinicio de bevacizumab para evaluación de posibles complicaciones isquémicas.

Objective: To present two cases of late anastotomotic breakdown by bevacizumab and compare it with the current literature. Case report: Two patients with metastatic rectal cancer, with neoadjuvant, surgical and adjuvant management including bevacizumab, presenting anastomotic ischemic complications, evidenced with endoscopy, images and directed biopsies, surgically resolved and taking biopsy of perianastomotic sites with ischemic changes. Discussion: There is evidence in the literature reporting late anastomotic ischemia and leaks with the use of bevacizumab. It seems prudent to consider and suspect this complication in a timely manner, especially in patients with risk factors. Conclusions: Ischemic events in surgical territories should be considered when using bevacizumab. Greater emphasis on patients with risk factors such as malnutrition, irradiation or male sex. Anastomotic-directed study prior to initiation of bevacizumab should be considered. To highlight bevacizumab suspension and restart times for the evaluation of possible ischemic complications.

Comparing RNA extraction methods to face the variations in RNA quality using two human biological matrices.

BACKGROUND: Nucleic acids, RNA among them, are widely used in biomedicine and Biotechnology. Because of their susceptibility to degradation by RNases, the handling and extraction process of RNA from cells and tissues require specialized personnel and standardized methods to guarantee high purity and integrity. Due to the diversity of techniques found in the market, a comparative study between different RNA extraction methods is useful to facilitate the best choice for the researcher or in research service platforms such as biobanks to see the traceability of the samples. METHODS AND RESULTS: In this study, we have compared seven different RNA extraction methods: manual (TRIzol™), semiautomated (QIAGEN™, Bio-Rad, Monarch®, and Canvax™), and fully automated (QIAcube™ and Maxwell®) processes, from two biological matrices: human Jurkat T cells and peripheral blood mononuclear cells (PBMC). Results showed marked differences in the RNA quality and functionality according to the method employed for RNA extraction and the matrix used. DISCUSSION: QIAcube™ and semi-automated extraction methods were perceived as the best options because of their lower variability, good functionality, and lower cost (P < 0.001). These data contribute to facilitating researchers or research service platforms (Biobanks) in decision-making practices and emphasize the relevance of the selection of the RNA extraction method in each experimental procedure or traceability study to guarantee both quality standards and its reproducibility.

Valoración de la cicatriz postquirúrgica de pacientes operados por quiste pilonidal según técnicas abiertas versus cerradas

Introducción: El quiste pilonidal puede ser abordado según técnicas quirúrgicas abiertas y cerradas, con distintos resultados estéticos. La cicatriz es un factor importante y representa un indicador de satisfacción. Una herramienta para valorar cicatrices es el cuestionario POSAS 2.0, adaptado transculturalmente para Chile. Objetivo: Conocer la valoración subjetiva de los pacientes operados de quiste pilonidal respecto a su cicatriz, según la técnica quirúrgica. Material y Método: Estudio es de carácter retrospectivo, observacional, transversal, analítico y de cohorte. Se aplica la escala de evaluación por el paciente del cuestionario POSAS 2.0, con una calificación desde 1 a 10, con puntaje total entre 7 y 70. Se recolectaron variables clínico-demográficas. Se aplicó estadística analítica, se compararon los resultados obtenidos entre técnicas abiertas y cerradas. Resultados. Se encuestaron 101 pacientes operados de quiste pilonidal entre 2013 y 2019, de los cuales 59 (59,4%) fueron de sexo masculino. La edad promedio fue de 23 años (DS 7,2). Del total, 22 (21,8%) de los pacientes fueron manejados con técnicas cerradas y 79 con técnicas abiertas (78,2%). El promedio del puntaje total de la escala fue 20 (DS 11,4), 22 en técnicas cerradas y 19,6 en técnicas abiertas. No se encontraron diferencias estadísticamente significativas. Conclusión: La cicatriz postoperatoria es valorada positivamente, con un puntaje que denota características similares a la piel normal. No existen diferencias significativas de la percepción de los pacientes respecto a su cicatriz. Esta es la primera comunicación chilena que evalúa la valoración subjetiva de pacientes sobre la cicatriz postoperatoria de quiste pilonidal.

Introduction: The pilonidal cyst can be approached according to open and closed surgical techniques, with different aesthetic results. The scar is an important factor and represents an indicator of satisfaction. A tool to assess scars is the POSAS 2.0 questionnaire, adapted cross-culturally for Chile. Objective: To know the subjective assessment of patients operated on for pilonidal cyst with respect to their scar, according to the surgical technique. Material and Method: This is a retrospective, observational, cross-sectional, analytical, and cohort study. The patient evaluation scale of the POSAS 2.0 questionnaire is applied, with a score from 1 to 10, with a total score between 7 and 70. Clinical-demographic variables were collected. Analytical statistics were applied, the results obtained between open and closed techniques were compared. Results: We surveyed 101 patients operated on for pilonidal cyst between 2013 and 2019, of which 59 (59.4%) were male. The mean age was 23 years (SD 7.2). Of the total, 22 (21.8%) of the patients were managed with closed techniques and 79 with open techniques (78.2%). The mean total score of the scale was 20 (SD 11.4), 22 in closed techniques and 19.6 in open techniques. No statistically significant differences were found. Conclusion: The postoperative scar is positively valued, with a score that denotes similar characteristics to the normal skin. There are no significant differences in patient's perception of their scar. This is the first chilean communication that evaluates the subjective assessment of patients on the postoperative scar of pilonidal cyst.

Vertebral osteomyelitis after spine instrumentation surgery: risk factors and management.

BACKGROUND: Vertebral osteomyelitis after spine instrumentation surgery (pVOM) is a rare complication. Most cases of infection occur early after surgery that involve skin and soft tissue and can be managed with debridement, antibiotics, and implant retention (DAIR). AIM: To identify pVOM risk factors and evaluate management strategies. METHODS: From a multicentre cohort of deep infection after spine instrumentation (IASI) cases (2010-2016), pVOM cases were compared with those without vertebral involvement. Early and late infections were defined (<60 days and >60 days after surgery, respectively). Multivariate analysis was used to explore risk factors. FINDINGS: Among 410 IASI cases, 19 (4.6%) presented with pVOM, ranging from 2% (7/347) in early to 19.1% (12/63) in late IASIs. After multivariate analysis, age (adjusted odds ratio (aOR): 1.10; 95% confidence interval (CI): 1.03-1.18), interbody fusion (aOR: 6.96; 95% CI: 2-24.18) and coagulase-negative staphylococci (CoNS) infection (aOR: 3.83; 95% CI: 1.01-14.53) remained independent risk factors for pVOM. Cases with pVOM had worse prognoses than those without (failure rate; 26.3% vs 10.8%; P = 0.038). Material removal was the preferred strategy (57.9%), mainly in early cases, without better outcomes (failure rate; 33.3% vs 50% compared with DAIR). Late cases managed with removal had greater success compared with DAIR (failure rate; 0% vs 40%; P = 0.067). CONCLUSION: Risk factors for pVOM are old age, use of interbody fusion devices and CoNS aetiology. Although the diagnosis leads to a worse prognosis, material withdrawn should be reserved for late cases or when spinal fusion is achieved.

Nuclear shell-model simulation in digital quantum computers.

The nuclear shell model is one of the prime many-body methods to study the structure of atomic nuclei, but it is hampered by an exponential scaling on the basis size as the number of particles increases. We present a shell-model quantum circuit design strategy to find nuclear ground states by exploiting an adaptive variational quantum eigensolver algorithm. Our circuit implementation is in excellent agreement with classical shell-model simulations for a dozen of light and medium-mass nuclei, including neon and calcium isotopes. We quantify the circuit depth, width and number of gates to encode realistic shell-model wavefunctions. Our strategy also addresses explicitly energy measurements and the required number of circuits to perform them. Our simulated circuits approach the benchmark results exponentially with a polynomial scaling in quantum resources for each nucleus. This work paves the way for quantum computing shell-model studies across the nuclear chart and our quantum resource quantification may be used in configuration-interaction calculations of other fermionic systems.

Preoperative oral practices and incidence of postoperative complications in hospital medical-surgical procedures: A meta-analysis.

BACKGROUND:  Oral decay prior to a hospital medical-surgical procedure is a risk factor for the development of postoperative complications. However, perioperative oral practices as a protective factor have not been studied. This review aims to evaluate the effectiveness of perioperative oral practices in the reduction of risk of developing postoperative complications in in-hospital medical surgical procedures. MATERIAL AND METHODS: This review and meta-analysis was conducted according to Cochrane guidelines. Medline, Scopus, Scielo, and Cochrane were consulted. Articles of the previous 10 years concerning adult patients undergoing perioperative oral practices prior to hospital medical-surgical procedures, were included. Data of the type of perioperative oral practice, type of postoperative complication and measures of effect on the development of complications were extracted. RESULTS: Of a pool of 1470 articles, 13 were included for systematic review and 10 for meta-analysis. The most common perioperative oral procedures were focalized approach (FA), referred to only the elimination of infectious foci in the oral cavity and comprehensive approach (CA), referred to a integral approach of the patient's oral health, both of which were mainly performed in oncologic surgeries, both were effective in the reduction of postoperative complications (RR=0.48, [95% CI 0.36 - 0.63]). The most reported postoperative complication was postoperative pneumonia. CONCLUSIONS: Perioperative oral management proved to be a protective factor against the development of postoperative complications.

Epidemiological and clinicopathological findings in 15 fatal outbreaks of salmonellosis in dairy calves and virulence genes in the causative Salmonella enterica Typhimurium and Dublin strains.

Salmonella enterica is a major food-borne pathogen that affects cattle-rearing systems worldwide. Little information is available on the epidemiology and pathology of salmonellosis and the virulence genes (VGs) carried by Salmonella in spontaneous outbreaks in cattle. We describe epidemiological findings in 15 fatal outbreaks of salmonellosis in Uruguayan dairy farms and the age, clinical signs, and pathology in 20 affected calves. We also describe the serotypes and frequencies of 17 VGs in the causative Salmonella strains and explore their associations with epidemiological, clinical, and pathological findings. Salmonella Typhimurium and Dublin were identified in 11/15 and 4/15 outbreaks, respectively. The most frequent reason for consultation was digestive disease (8 outbreaks caused by S. Typhimurium), followed by sudden death (4 outbreaks, 3 caused by S. Dublin). Morbidity, mortality, and lethality ranged 4.8-100%, 3.8-78.9%, and 10-100%, without significant differences between serotypes. Diarrhea, the most common clinical sign (14 cases), was associated with the Typhimurium serotype (OR = 26.95), especially in ≤ 30-day-old calves with fibrinous enteritis as the main autopsy finding. The Dublin serotype affected ≥ 50-day-old calves and was associated with fibrinosuppurative splenitis (p = 0.01) and tubulointerstitial nephritis (OR = 48.95). The chances of the Dublin serotype increased significantly with age. There was low variability of VG across serotypes. The pefA gene was associated with the Typhimurium serotype (OR = 21.95), macroscopic enteritis (p = 0.03), and microscopic fibrinosuppurative splenitis (p = 0.04). Understanding the epidemiology, pathology, and virulence of S. enterica at the farm level is key to delineating prevention and control strategies to mitigate its impact on animal and human health.

Algoritmo para el Manejo del Trauma Balístico Maxilofacial. Caso Clínico y Revisión de la Literatura

RESUMEN: El trauma maxilofacial por proyectil balístico corresponde a un escenario desafiante para los servicios de alta complejidad debido a su alta mortalidad y morbilidad, asociando gran costo en insumos, hospitalización y recursos, en contraste con la funcionalidad hacia una inserción laboral eficiente. En este sentido la cirugía de reconstrucción se relaciona con el daño presentado en los tejidos blandos y duros, siendo clasificada en etapa inmediata (reducción abierta y fijación con osteosintesis) y/o mediata en donde el uso de tutores externos continúa siendo una propuesta válida. Reporte de un paciente masculino de 38 años, que ingresa por trauma balístico maxilofacial con daño extenso en tejido blando y conminución en cuerpo de mandíbula, siendo tratado de manera mediata por estabilización de tutores externos y posterior reconstrucción con injerto autólogo no vascularizado; presentándose complicación intraoperatoria de comunicación de acceso extraoral con intraoral; cerrado con injerto loco regional de cuerpo adiposo de mejilla. Paciente presenta evolución favorable. Se realizó una revisión de literatura en relación al uso de cuerpo adiposo de mejilla en cirugía maxilofacial reconstructiva. El uso de tutores externos se presenta como una alternativa válida y favorable para traumatismos con daño extenso en tejido blando y duro. El uso de cuerpo adiposo de mejilla se reporta en variados usos en cirugía oral y maxilofacial, sin embargo, su uso como injerto locoregional para cierre de procesos que requieren ser injertados es escaso; planteándose como una propuesta en este reporte.

ABSTRACT: Ballistic projectile maxillofacial trauma corresponds to a challenging scenario for highly complex services due to high mortality and morbidity, associating high cost in supplies, hospitalization and resources, in contrast to the functionality towards efficient labor insertion. In this sense, reconstruction surgery is related to the damage presented in the soft and hard tissues, being classified in the immediate stage (open reduction and fixation with osteosynthesis) and / or mediate where the use of external tutors continues to be a valid proposal. Report of a 38-year-old male patient admitted for maxillofacial ballistic trauma with extensive soft tissue damage and comminution in the mandible body, being treated mediate by stabilization of external tutors and subsequent reconstruction with a non- autologous graft. vascularized; presenting intraoperative complication of communication between extraoral and intraoral access; closed with a locoregional flap of the adipose body of the cheek. The patient presents a favorable evolution. A literature review was carried out in relation to the use of the adipose body of the cheek in reconstructive maxillofacial surgery. The use of external tutors is presented as a valid and favorable alternative for trauma with extensive damage to soft and hard tissue. The use of the adipose body of the cheek is reported in various uses in oral and maxillofacial surgery, however, its use as a locoregional graft for closing processes that require grafting is scarce; it is presented as a proposal in this report.

Suprapatellar tibial nailing, why have we changed? / Enclavado de tibia suprapatelar, ¿por qué hemos cambiado?

INTRODUCTION: Endomedullary nailing using the infrapatellar approach (IP) is considered the gold standard for the treatment of tibial diaphyseal fractures, however, it has been associated with greater difficulty in reduction and complications such as malalignment in procurvatum and anterior knee pain. The suprapatellar approach (SP) arises as an alternative to solve these aspects, also being associated with a shorter intraoperative time and a lower dose and fluoroscopy time. MATERIAL AND METHODS: Retrospective comparative study between a group of 22 fractures treated by SP approach and another of 30 fractures intervened by IP transtendinous approach. Perioperative variables were analyzed, as well as clinical, radiological, and functional aspects in outpatient visits at 3, 6 and 12 months. RESULTS: No differences were found between groups in terms of intraoperative time, anemization, quality of reduction or complications during follow-up, among others. At 12 months, 12 (54.5%) SP cases and 16 (53.3%) IP presented anterior knee pain, without significant differences. In the evaluation scales, significant differences were recorded in the IKDC (International Knee Documentation Committee) in favor of the SP technique 88.45 (76.44-91.1) vs. IP 69 (49.95-80) (p=.006), with no significant differences in other functional scales analyzed. CONCLUSIONS: According to what has been described so far in the literature, the present study supports the tendency toward SP nailing by improving the functional results (IKDC) in the medium term compared to the traditional IP technique, without increasing complications. Likewise, surgeons perceive greater technical ease for reduction and simplicity in obtaining intraoperative radiological images.

Enclavado de tibia suprapatelar, ¿por qué hemos cambiado? / Suprapatellar tibial nailing, why have we changed?

Introducción: El enclavado endomedular mediante abordaje infrapatelar (IP) se considera el gold estándar del tratamiento de las fracturas diafisarias de tibia, sin embargo, se ha asociado a mayor dificultad para la reducción y complicaciones como la mala alineación en procurvatum y al dolor anterior de rodilla. El abordaje suprapatelar (SP) surge como alternativa para solventar estos aspectos, asociándose también con un menor tiempo intraoperatorio y menor dosis y tiempo de fluoroscopia. Material y métodos: Estudio retrospectivo comparativo entre: un grupo de 22 fracturas intervenidas mediante abordaje SP y otro de 30 fracturas intervenidas por abordaje IP trastendinoso. Se analizaron variables perioperatorias y aspectos clínicos, radiológicos y funcionales en consulta a los 3, 6 y 12 meses. Resultados: No se encontraron diferencias entre grupos en cuanto a tiempo intraoperatorio, anemización, calidad de la reducción, o complicaciones en el seguimiento, entre otros. A los 12 meses, 12 (54,5%) casos SP y 16 (53,3%) IP presentaban dolor anterior de rodilla, sin diferencias significativas. En las escalas de evaluación, se registraron diferencias significativas en la IKDC (International Knee Documentation Committee) a favor de la técnica SP (88,45 [76,44-91,1] vs. IP 69 [49,95-80]) (p=0,006), sin diferencias significativas en otras escalas funcionales analizadas. Conclusiones: En consonancia con lo hasta ahora descrito en la literatura, el presente estudio apoya la tendencia hacia el enclavado SP por mejorar los resultados funcionales (IKDC) a medio plazo respecto a la técnica tradicional IP, sin aumentar las complicaciones. Asimismo se percibe por los cirujanos una mayor facilidad técnica para la reducción y sencillez en la obtención de imágenes radiológicas intraoperatorias.(AU)

Introduction: Endomedullary nailing using the infrapatellar approach (IP) is considered the gold standard for the treatment of tibial diaphyseal fractures, however, it has been associated with greater difficulty in reduction and complications such as malalignment in procurvatum and anterior knee pain. The suprapatellar approach (SP) arises as an alternative to solve these aspects, also being associated with a shorter intraoperative time and a lower dose and fluoroscopy time. Material and methods: Retrospective comparative study between a group of 22 fractures treated by SP approach and another of 30 fractures intervened by IP transtendinous approach. Perioperative variables were analyzed, as well as clinical, radiological, and functional aspects in outpatient visits at 3, 6 and 12 months. Results: No differences were found between groups in terms of intraoperative time, anemization, quality of reduction or complications during follow-up, among others. At 12 months, 12 (54.5%) SP cases and 16 (53.3%) IP presented anterior knee pain, without significant differences. In the evaluation scales, significant differences were recorded in the IKDC (International Knee Documentation Committee) in favor of the SP technique 88.45 (76.44–91.1) vs. IP 69 (49.95–80) (p=.006), with no significant differences in other functional scales analyzed. Conclusions: According to what has been described so far in the literature, the present study supports the tendency toward SP nailing by improving the functional results (IKDC) in the medium term compared to the traditional IP technique, without increasing complications. Likewise, surgeons perceive greater technical ease for reduction and simplicity in obtaining intraoperative radiological images.(AU)

Suprapatellar tibial nailing, why have we changed? / Enclavado de tibia suprapatelar, ¿por qué hemos cambiado?

Introduction: Endomedullary nailing using the infrapatellar approach (IP) is considered the gold standard for the treatment of tibial diaphyseal fractures, however, it has been associated with greater difficulty in reduction and complications such as malalignment in procurvatum and anterior knee pain. The suprapatellar approach (SP) arises as an alternative to solve these aspects, also being associated with a shorter intraoperative time and a lower dose and fluoroscopy time. Material and methods: Retrospective comparative study between a group of 22 fractures treated by SP approach and another of 30 fractures intervened by IP transtendinous approach. Perioperative variables were analyzed, as well as clinical, radiological, and functional aspects in outpatient visits at 3, 6 and 12 months. Results: No differences were found between groups in terms of intraoperative time, anemization, quality of reduction or complications during follow-up, among others. At 12 months, 12 (54.5%) SP cases and 16 (53.3%) IP presented anterior knee pain, without significant differences. In the evaluation scales, significant differences were recorded in the IKDC (International Knee Documentation Committee) in favor of the SP technique 88.45 (76.44–91.1) vs. IP 69 (49.95–80) (p=.006), with no significant differences in other functional scales analyzed. Conclusions: According to what has been described so far in the literature, the present study supports the tendency toward SP nailing by improving the functional results (IKDC) in the medium term compared to the traditional IP technique, without increasing complications. Likewise, surgeons perceive greater technical ease for reduction and simplicity in obtaining intraoperative radiological images.(AU)

Introducción: El enclavado endomedular mediante abordaje infrapatelar (IP) se considera el gold estándar del tratamiento de las fracturas diafisarias de tibia, sin embargo, se ha asociado a mayor dificultad para la reducción y complicaciones como la mala alineación en procurvatum y al dolor anterior de rodilla. El abordaje suprapatelar (SP) surge como alternativa para solventar estos aspectos, asociándose también con un menor tiempo intraoperatorio y menor dosis y tiempo de fluoroscopia. Material y métodos: Estudio retrospectivo comparativo entre: un grupo de 22 fracturas intervenidas mediante abordaje SP y otro de 30 fracturas intervenidas por abordaje IP trastendinoso. Se analizaron variables perioperatorias y aspectos clínicos, radiológicos y funcionales en consulta a los 3, 6 y 12 meses. Resultados: No se encontraron diferencias entre grupos en cuanto a tiempo intraoperatorio, anemización, calidad de la reducción, o complicaciones en el seguimiento, entre otros. A los 12 meses, 12 (54,5%) casos SP y 16 (53,3%) IP presentaban dolor anterior de rodilla, sin diferencias significativas. En las escalas de evaluación, se registraron diferencias significativas en la IKDC (International Knee Documentation Committee) a favor de la técnica SP (88,45 [76,44-91,1] vs. IP 69 [49,95-80]) (p=0,006), sin diferencias significativas en otras escalas funcionales analizadas. Conclusiones: En consonancia con lo hasta ahora descrito en la literatura, el presente estudio apoya la tendencia hacia el enclavado SP por mejorar los resultados funcionales (IKDC) a medio plazo respecto a la técnica tradicional IP, sin aumentar las complicaciones. Asimismo se percibe por los cirujanos una mayor facilidad técnica para la reducción y sencillez en la obtención de imágenes radiológicas intraoperatorias.(AU)

Dolor, calidad de vida y salud mental en pacientes con gonalgia por gonartrosis: estudio de casos y controles / Pain, quality of life and mental health in patients with gonalgia due to gonarthrosis: Cases and controls study

Objetivo: Evaluar el dolor, la calidad de vida y el estado psicológico en pacientes con gonalgia por gonartrosis. Material y métodos: Estudio epidemiológico, multicéntrico, de casos y controles. Se incluyeron 1.152 pacientes (576 con artrosis y 576 sin artrosis) apareados por edad y sexo, procedentes de 63 centros de salud de España. Se les administró la escala visual analógica de dolor de Huskisson y los cuestionarios EuroQol y Goldberg. Se realizó un análisis descriptivo y comparativo de los datos en ambos grupos. Se estudiaron los factores que influían en la CV y salud mental de los pacientes artrósicos con modelos de regresión logística. Resultados: Se incluyeron 576 pacientes casos y 576 controles. El 70,3% eran mujeres en ambos grupos. La puntuación media en la escala visual analógica de los artrósicos fue 65,2±4,9mm correspondiente a una intensidad moderada. El cuestionario EuroQol indicó peor estado de salud (p<0,05) en los pacientes con artrosis en todas sus dimensiones. El cuestionario Goldberg mostró la presencia de psicopatología en el 36,5% (n=209) de los casos, frente a un 14,0% (n=80) en los controles (p<0,001). El dolor fue la variable que afectó a la CV en todas las dimensiones (p<0,001). Conclusiones: Los pacientes con artrosis manifiestan dolor moderado, limitación de la movilidad, del cuidado personal y de las actividades cotidianas que repercute negativamente en su CV y psicológicamente se encuentran más afectados. Es prioritario desarrollar estrategias de autocuidado y tratamiento en estos pacientes para mejorar globalmente su CV (AU)

Objective: To evaluate pain, quality of life and psychological state in patients with gonalgia due to gonarthrosis. Material and methods: Epidemiological, multicenter, case–control study. 1.152 patients were included (576 with arthrosis and 576 without arthrosis) matched by age and sex, from 63 health centers in Spain. The Huskisson Pain Scale (VAS), the EuroQol and Goldberg questionnaires were administered. A descriptive and comparative analysis of the data was carried out in both groups. Factors influencing the quality of life and mental health of arthritic patientes were studied with logistic regression models. Results: 576 case patients and 576 controls were included. 70.3% were women in both groups. The mean score in the VAS score of the arthritic patients was 65±4.9mm corresponding to a moderate intensity. The EQ-5D questionnaire indicated a worse state of health (P<.05) in patients with osteoarthritis in each of its dimensions. In the GHQ-12 questionnaire, the presence of psychopathology was detected in 36.5% (n=209) of patients with osteoarthritis compared to 14.0% (n=80) in controls (P<.001). Pain was the variable that affected quality of life in all dimensions (P<.001). Conclusions: Patients with arthrosis manifest moderate pain due to this disease. They present a limitation of mobility, personal care and daily activities that negatively affects their quality of life and psychologically they are more affected. It is a priority to develop self-care and treatment strategies in this group of subjects to globally improve their quality of life (AU)