Validez y confiabilidad del Inventario de orientación suicida ­ ISO-30 en una población colombiana / Validación de la escala de orientación al suicidio ISO-30 / Validity and reliability of the Inventory of suicide orientation ­ ISO-30 in a colombian population

El presente estudio instrumental evaluó las propiedades psicométricas del Inventario de Orientación Suicida ­ ISO-30 con 1922 adolescentes escolarizados de la ciudad de Bogotá. La validez de constructo del inventario se estableció a través de un análisis factorial confirmatorio, utilizándose el método de mínimos cuadrados generalizados (GLS), dando lugar un modelo factorial sustentable, compuesto por cinco factores, igual al inventario original. La confiabilidad del instrumento se estableció, a través del coeficiente Alfa de Cronbach, obteniéndose una confiabilidad excelente (α= .0915) y un coeficiente Omega (Ω=.742). El análisis de reactivos relativo al poder de discriminación del inventario obtuvo un 57% en las correlaciones ítem-escala total con un nivel de discriminación excelente. Se presenta evidencia respecto a la validez y confiabilidad del ISO-30 para evaluar la orientación al suicidio en adolescentes colombianos

The present instrumental study evaluated the psychometric properties of the Inventory of Suicide Orientation - ISO-30 with 1922 school adolescents from Bogotá. The construct validity of the inventory was established through confirmatory factor analysis, using the generalized least squares (GLS) technique, through which a sustainable factorial model was obtained, composed of five factors equal to the original inventory. The reliability of the instrument was established using Cronbach's Alpha coefficient with an excellent result (α= .915) and an omega coefficient (Ω=.742). The analysis of the items, relative to the discrimination power of the items, obtained 57% in item-total scale correlations with an excellent level of discrimination power. These findings prove ISO-30 to be a valid and reliable instrument for evaluating suicide orientation among Colombian adolescents.

Lisen&Curate: A platform to facilitate gathering textual evidence for curation of regulation of transcription initiation in bacteria.

The number of published papers in biomedical research makes it rather impossible for a researcher to keep up to date. This is where manually curated databases contribute facilitating the access to knowledge. However, the structure required by databases strongly limits the type of valuable information that can be incorporated. Here, we present Lisen&Curate, a curation system that facilitates linking sentences or part of sentences (both considered sources) in articles with their corresponding curated objects, so that rich additional information of these objects is easily available to users. These sources are going to be offered both within RegulonDB and a new database, L-Regulon. To show the relevance of our work, two senior curators performed a curation of 31 articles on the regulation of transcription initiation of E. coli using Lisen&Curate. As a result, 194 objects were curated and 781 sources were recorded. We also found that these sources are useful to develop automatic approaches to detect objects in articles by observing word frequency patterns and by carrying out an open information extraction task. Sources may help to elaborate a controlled vocabulary of experimental methods. Finally, we discuss our ecosystem of interconnected applications, RegulonDB, L-Regulon, and Lisen&Curate, to facilitate the access to knowledge on regulation of transcription initiation in bacteria. We see our proposal as the starting point to change the way experimentalists connect a piece of knowledge with its evidence using RegulonDB.