Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 29
Filtrar
1.
J Ment Health ; : 1-9, 2022 May 03.
Artículo en Inglés | MEDLINE | ID: mdl-35502838

RESUMEN

Purpose: Adolescents are the least likely to seek help for their mental health problems. School may be an important route to improve early recognition of adolescents with mental health problems in need for support, but little is known about the barriers to school support.Materials and methods: Data were collected in a longitudinal cohort study of Dutch adolescents (age 12-16) in secondary school (n = 956). We assessed the relation between level of psychosocial problems at the beginning of the school year (T1) and the support used in school at the end of that school year (T2), whether the willingness to talk to others (measured at T1) mediates this relation, and whether stigma towards help-seeking (T1) moderates this mediation.Results: Adolescents with more psychosocial problems were more likely to use support in school and were less willing to talk to others about their problems, but the willingness to talk to others was not a mediator. Stigma moderated the relationship between psychosocial problems and willingness to talk to others.Conclusions: Most adolescents with psychosocial problems get support in Dutch secondary school regardless of their willingness to talk to others about their problems. However, perceiving stigma towards help-seeking makes it less likely for someone to talk about their problems.

2.
J Nephrol ; 35(6): 1709-1719, 2022 07.
Artículo en Inglés | MEDLINE | ID: mdl-34985613

RESUMEN

BACKGROUND: Health literacy is the ability to deal with information related to one's health. Patients with low health literacy have poor disease-management skills for chronic diseases, such as chronic kidney disease (CKD). This could influence the number and combination of their diseases. METHODS: We included adult patients with CKD stages 1-5 from the Lifelines Study (n = 2,742). We assessed the association between low health literacy and the number and patterns of comorbidities, considering them globally and stratified by age and sex, using multinomial logistic regression and latent class analysis, respectively. RESULTS: Low health literacy was associated with a higher number of comorbidities in the crude models, and after adjustment for age, sex, eGFR, smoking, and BMI. In the crude model, the OR for low health literacy increased from 1.71 (1.25-2.33) for two comorbidities to 2.71 (2.00-3.68) for four comorbidities. In the fully-adjusted model, the associations remained significant with a maximum OR of 1.70 (1.16-2.49) for four comorbidities. The patterns of multimorbidity were similar for low and adequate health literacy, overall and by sex, bur tended to be different for patients older than 65. Older patients with low health literacy had higher comorbidity prevalence and a relatively greater share of cardiovascular, psychiatric, and central nervous system diseases. CONCLUSIONS: Among CKD patients, low health literacy is associated with more multimorbidity. Health literacy is not associated with patterns of multimorbidity in younger patients, but a difference was observed in older ones. Improving low health literacy could be an intervention efficient also in decreasing multimorbidity in CKD patients.


Asunto(s)
Alfabetización en Salud , Insuficiencia Renal Crónica , Adulto , Anciano , Enfermedad Crónica , Comorbilidad , Humanos , Multimorbilidad , Prevalencia , Insuficiencia Renal Crónica/diagnóstico , Insuficiencia Renal Crónica/epidemiología , Insuficiencia Renal Crónica/terapia
3.
Eur Child Adolesc Psychiatry ; 29(11): 1547-1554, 2020 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-31925546

RESUMEN

Although among adolescents with psychosocial problems low health literacy may increase the risk of poor treatment outcomes, the contributing mechanisms within treatment remain unclear. A better understanding of these mechanisms could contribute to improved treatment processes and outcomes. This study aims to examine the relationship between functional health literacy, treatment processes (treatment adherence, learning processes), and treatment outcome (level of psychosocial problems) in adolescents in psychosocial care. We used data from a prospective cohort study among adolescents aged 12-18 (N = 390), collected in four successive measurements: at entry into care, and 3, 12, and 24 months thereafter. We used a mixed effect model to investigate the association between level of functional health literacy (adequate vs. inadequate) and treatment processes (treatment adherence, learning processes) and treatment outcome (level of psychosocial problems). Between adolescents with adequate and inadequate functional health literacy, we found no differences or change over time in adherence or learning processes. The level of psychosocial problems significantly declined over time (ß = - 1.70, 95% CI [- 2.72, - 0.69], p = .001) to a similar degree in both groups, though, in all measurements, the level was consistently higher for adolescents with inadequate health literacy. We conclude that health literacy levels did not affect change in treatment processes nor in outcomes of psychosocial treatment. However, the consistently higher level of psychosocial problems among adolescents with inadequate health literacy suggests an unaddressed need in psychosocial care.


Asunto(s)
Alfabetización en Salud/métodos , Psicoterapia/métodos , Adolescente , Niño , Preescolar , Femenino , Humanos , Masculino , Estudios Prospectivos , Resultado del Tratamiento
4.
Zookeys ; 840: 21-34, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-31065226

RESUMEN

Enneanigeriensis sp. n. is described from southeastern Nigeria on the basis of external and internal shell morphology. Following Pilsbry's formal criteria of a single palatal fold and corresponding external furrow, the new species may be assigned to Parennea. Enneanigeriensis sp. n. exhibits substantial similarity with E.serrata, a species from Cameroon, in the cylindrical shell shape, crenulate suture, and internal shell morphology, indicating that the two species are closely related. CT scanning confirmed the presence of only a single palatal fold in E.nigeriensis sp. n. and two in E.serrata. In spite of this, the Nigerian species is provisionally assigned to Ennea rather than Parennea, suggesting that the characters used to define Ennea and Parennea are insufficient to delimit natural groups of species. The holotype of E.serrata is examined for the first time since its description in 1896 and a redescription of the species is provided based on the two shells hitherto known. Study of the original specimens recorded as Ptychotrema (Parennea) sulciferum by Degner from Liberia reveals these to belong to Enneacf.thompsonae. The Nigerian shell recorded by van Bruggen as Ptychotrema (Parennea) aequatoriale proved to be a specimen of Enneacf.perforata. As a result, no species attributable to Parennea now appear to be known in West Africa; in contrast, numerous species are known from central and eastern Africa.

5.
Ned Tijdschr Geneeskd ; 160: D294, 2016.
Artículo en Holandés | MEDLINE | ID: mdl-27484423

RESUMEN

In the Netherlands, almost 30 percent of adults have limited levels of health literacy. They have difficulties finding, understanding and using health information. Comprehensible health information is extra important for people with low health literacy. A systematic review revealed that narrative health communication is a promising strategy to increase comprehension. We have investigated which interventions may improve comprehensibility of health-related documents for older adults with different levels of health literacy. We are currently exploring if and how photo stories on care and health topics can support people with low health literacy.


Asunto(s)
Alfabetización en Salud , Educación del Paciente como Asunto , Fotograbar , Comprensión , Humanos , Narración , Países Bajos
6.
Artículo en Alemán | MEDLINE | ID: mdl-26122363

RESUMEN

Health literacy has been defined as the degree to which people are able to access, understand, appraise, and communicate information to make informed decisions about their health. It is therefore essential to be able to engage with the demands of different health contexts and to stay healthy. The topic of health literacy is thus receiving growing political and scientific attention and is becoming increasingly important in Germany too. Results of a survey on health literacy in Germany that were published by the AOK's scientific research institute, WidO, in 2014, stress the need for health literacy improvement. These results are briefly summarized. At a European level, the IROHLA (Intervention Research on Health Literacy among Ageing population) project was started in December 2012. IROHLA is aimed at introducing evidence-based guidelines for policy and practice to improve health literacy among the ageing population in the member states of the European Union (EU). The project consortium is led by the University Medical Center Groningen (UMCG) and consists of 22 partners from nine EU member states. German partners in the project are the Federal Centre for Health Education (Bundeszentrale für gesundheitliche Aufklärung-BZgA), the Federal Association of the AOK (AOK-Bundesverband), liveonline coaching, and Jacobs University Bremen. The purpose of this article is to present the major findings of the IROHLA project and to point out approaches to improving health literacy among older adults. A key aspect within IROHLA is the comprehensive approach, which targets multiple groups, i.e., individuals and their social environment, in addition to professionals and the health system.


Asunto(s)
Educación en Salud/organización & administración , Alfabetización en Salud/organización & administración , Promoción de la Salud/organización & administración , Modelos Organizacionales , Anciano , Anciano de 80 o más Años , Europa (Continente) , Femenino , Alemania , Educación en Salud/métodos , Alfabetización en Salud/métodos , Promoción de la Salud/métodos , Humanos , Masculino , Persona de Mediana Edad
7.
J Abnorm Child Psychol ; 40(6): 923-31, 2012 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-22427248

RESUMEN

The present study examined the joint development of substance use and externalizing problems in early and middle adolescence. First, it was tested whether the relevant groups found in previous studies i.e., those with an early onset, a late onset, and no onset or low levels of risk behavior could be identified, while using a developmental model of a single, underlying construct of risk behavior. Second, departing from Moffitt's taxonomy of antisocial behavior, it was tested if early, but not late, onset risk behavior is predicted by a problematic risk profile in childhood. Data were used from TRAILS, a population based cohort study, starting at age 11 with two follow-ups at mean ages of 13.6 and 16.3 years. Latent transition analyses demonstrated that, both in early and middle adolescence, a single underlying construct of risk behavior, consisting of two classes (labeled as low and high risk behavior), adequately represented the data. Respondents could be clearly classified into four possible transition patterns from early to middle adolescence, with a transition from high to low being almost non-existent (2.5 %), low to low (39.4 %) and low to high (41.8 %) being the most prevalent, and high to high (16.2 %) substantial. As hypothesized, only the high-high group was characterized by a clear adverse predictor profile in late childhood, while the low-high group was not. This study demonstrates that the development of substance use is correlated with externalizing problems and underscores the theory that etiologies of early and later onset risk behavior are different.


Asunto(s)
Consumo de Bebidas Alcohólicas/psicología , Síntomas Conductuales/etiología , Fumar/psicología , Adolescente , Factores de Edad , Femenino , Humanos , Estudios Longitudinales , Masculino , Fumar Marihuana/psicología , Países Bajos , Factores de Riesgo , Asunción de Riesgos
8.
Eur J Pain ; 16(1): 150-9, 2012 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-21705247

RESUMEN

Investigating possible psychosocial predictors of unexplained chronic pain in adolescents is crucial in understanding its development and prevention. A general population sample of adolescents (n = 2230) from the TRAILS cohort study was investigated longitudinally to assess the influence of maternal vulnerability, in terms of anxiety, depression and stress, and parenting stress at age 10-12 years, on the presence of chronic pain at age 12-15 years. Of these adolescents, 269 (12.9%) reported experiencing chronic pain, of which 77% reported severe chronic pain and 22% reported multiple chronic pain. Maternal anxiety, maternal stress and higher levels of parenting stress were related to chronic pain at a later age. Subgroup analyses showed similar results for adolescents with severe chronic pain. Mediation analyses indicated that parenting stress mediates the effect between maternal anxiety, or stress, and chronic pain. The findings suggest that interventions to diminish maternal feelings of anxiety and stress, while in turn adjusting maternal behaviour, may prevent the development of chronic pain in adolescence.


Asunto(s)
Dolor Crónico/epidemiología , Dolor Crónico/psicología , Madres/psicología , Responsabilidad Parental/psicología , Estrés Psicológico/psicología , Adolescente , Ansiedad/psicología , Niño , Estudios de Cohortes , Recolección de Datos , Depresión/psicología , Femenino , Encuestas Epidemiológicas , Humanos , Modelos Logísticos , Masculino , Pruebas Neuropsicológicas , Oportunidad Relativa , Manejo del Dolor , Dimensión del Dolor , Escalas de Valoración Psiquiátrica , Estrés Psicológico/etiología , Resultado del Tratamiento
9.
J Thromb Haemost ; 9(11): 2268-77, 2011 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-21883886

RESUMEN

BACKGROUND: Because activated thrombin activatable fibrinolysis inhibitor (TAFIa) has very powerful antifibrinolytic properties, co-administration of t-PA and a TAFIa inhibitor enhances t-PA treatment. OBJECTIVE: We aimed to generate nanobodies specifically inhibiting the TAFIa activity and to test their effect on t-PA induced clot lysis. RESULTS: Five nanobodies, raised towards an activated more stable TAFIa mutant (TAFIa A(147) -C(305) -I(325) -I(329) -Y(333) -Q(335) ), are described. These nanobodies inhibit specifically TAFIa activity, resulting in an inhibition of up to 99% at a 16-fold molar excess of nanobody over TAFIa, IC(50) 's range between 0.38- and > 16-fold molar excess. In vitro clot lysis experiments in the absence of thrombomodulin (TM) demonstrate that the nanobodies exhibit profibrinolytic effects. However, in the presence of TM, one nanobody exhibits an antifibrinolytic effect whereas the other nanobodies show a slight antifibrinolytic effect at low concentrations and a pronounced profibrinolytic effect at higher concentrations. This biphasic pattern was highly dependent on TM and t-PA concentration. The nanobodies were found to bind in the active-site region of TAFIa and their time-dependent differential binding behavior during TAFIa inactivation revealed the occurrence of a yet unknown intermediate conformational transition. CONCLUSION: These nanobodies are very potent TAFIa inhibitors and constitute useful tools to accelerate fibrinolysis. Our data also demonstrate that the profibrinolytic effect of TAFIa inhibition may be reversed by the presence of TM. The identification of a new conformational transition provides new insights into the conformational inactivation of the unstable TAFIa.


Asunto(s)
Anticuerpos/farmacología , Carboxipeptidasa B2/inmunología , Fibrinólisis/efectos de los fármacos , Fibrinolíticos , Anticuerpos/uso terapéutico , Carboxipeptidasa B2/química , Carboxipeptidasa B2/genética , Humanos , Proteínas Mutantes/inmunología , Biblioteca de Péptidos , Conformación Proteica
10.
Psychol Med ; 35(12): 1825-35, 2005 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-16300695

RESUMEN

BACKGROUND: We investigated the links between familial loading, preadolescent temperament, and internalizing and externalizing problems in adolescence, hereby distinguishing effects on maladjustment in general versus dimension-specific effects on either internalizing or externalizing problems. METHOD: In a population-based sample of 2230 preadolescents (10-11 years) familial loading (parental lifetime psychopathology) and offspring temperament were assessed at baseline by parent report, and offspring psychopathology at 2.5-years follow-up by self-report, teacher report and parent report. We used purified measures of temperament and psychopathology and partialled out shared variance between internalizing and externalizing problems. RESULTS: Familial loading of internalizing psychopathology predicted offspring internalizing but not externalizing problems, whereas familial loading of externalizing psychopathology predicted offspring externalizing but not internalizing problems. Both familial loadings were associated with Frustration, low Effortful Control, and Fear. Frustration acted as a general risk factor predicting severity of maladjustment; low Effortful Control and Fear acted as dimension-specific risk factors that predicted a particular type of psychopathology; whereas Shyness, High-Intensity Pleasure, and Affiliation acted as direction markers that steered the conditional probability of internalizing versus externalizing problems, in the event of maladjustment. Temperament traits mediated one-third of the association between familial loading and psychopathology. Findings were robust across different composite measures of psychopathology, and applied to girls as well as boys. CONCLUSIONS: With regard to familial loading and temperament, it is important to distinguish general risk factors (Frustration) from dimension-specific risk factors (familial loadings, Effortful Control, Fear), and direction markers that act as pathoplastic factors (Shyness, High-Intensity Pleasure, Affiliation) from both types of risk factors. About one-third of familial loading effects on psychopathology in early adolescence are mediated by temperament.


Asunto(s)
Trastornos Mentales/epidemiología , Trastornos Mentales/psicología , Desarrollo de la Personalidad , Temperamento , Adolescente , Niño , Femenino , Estudios de Seguimiento , Humanos , Masculino , Vigilancia de la Población , Prevalencia , Encuestas y Cuestionarios
12.
Psychoneuroendocrinology ; 30(5): 483-95, 2005 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-15721059

RESUMEN

The hypothalamic-pituitary-adrenal (HPA)-axis is a central component of the body's neuroendocrine response to stress. Its major end-product cortisol has profound effects on mood and behavior. Although it has often been suggested, it remains unknown whether differences in HPA-axis physiology are part of an individual's vulnerability to psychopathology, and constitute a causal factor in its development. In order to study the contribution of HPA-axis physiology to the development of psychopathology, we measured HPA-axis physiology in a community-cohort of 1768 10-12 year-old children. The aims of the here presented study were twofold: (1) to obtain data on HPA-axis function in a large cohort of pre- and early-adolescent children, both in terms of total hormonal output and in terms of the dynamics of cortisol secretion (by means of the cortisol awakening response); and (2) to study potential confounders of the cortisol-psychopathology relationship in this age group, such as season of sampling, age, gender, pubertal development, perinatal variables and BMI. We found a wide interindividual variability in HPA-axis function. An increase in cortisol in the first 30 min after awakening was present in 70.7% of children, but the increase appears lower in children than in adults. In addition, this study suggests that season of sampling and gender may act as potential confounders in the cortisol-psychopathology relationship. We will follow these children longitudinally for the development of psychopathology in the period from childhood into adulthood. This period covers adolescence, which is a critical time for the appearance and development of psychiatric disorders.


Asunto(s)
Hidrocortisona/metabolismo , Sistema Hipotálamo-Hipofisario/metabolismo , Saliva/metabolismo , Envejecimiento/fisiología , Área Bajo la Curva , Peso al Nacer/fisiología , Composición Corporal/fisiología , Niño , Ritmo Circadiano , Estudios Cruzados , Femenino , Humanos , Individualidad , Masculino , Países Bajos/epidemiología , Pruebas Neuropsicológicas , Población , Embarazo , Pubertad/fisiología , Valores de Referencia , Estaciones del Año , Caracteres Sexuales
13.
Cochrane Database Syst Rev ; (1): CD001250, 2002.
Artículo en Inglés | MEDLINE | ID: mdl-11869597

RESUMEN

BACKGROUND: Ultrasound is used in the treatment of a wide variety of musculoskeletal disorders. OBJECTIVES: To evaluate the effects of ultrasound therapy in the treatment of acute ankle sprains. SEARCH STRATEGY: We searched the Cochrane Musculoskeletal Injuries Group specialised register (November 15th 2001), the Cochrane Controlled Trials Register (The Cochrane Library Issue 3, 2001), MEDLINE (1966 to October 2001), EMBASE (1983 to 2001 week 45), CINAHL (1982 to October week 4 2001), and PEDro - The Physiotherapy Evidence Database (http://ptwww.cchs.usyd.edu.au/pedro/ accessed 15.11.01). We also searched the Cochrane Rehabilitation and Related Therapies Field database, reference lists of articles, and contacted colleagues. SELECTION CRITERIA: Randomised or pseudo-randomised trials were included in the review if the following conditions were met: at least one study group was treated with active ultrasound; the study included patients with acute lateral ankle sprains; and outcome measures included general improvement, pain, swelling, functional disability, or range of motion. Final selection of papers was conducted by two independent reviewers. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed trial quality using a standardised checklist, and extracted data. Whenever possible, the results were analysed on an intention-to-treat basis. Relative risks together with 95 per cent confidence intervals were calculated for dichotomous outcomes, and weighted or, where different scales were used, standardised mean differences together with 95 per cent confidence intervals for continuous outcome measures. Pooling of data was undertaken where there was clinical homogeneity in terms of subjects, treatments, outcomes, and follow-up time points. MAIN RESULTS: Five trials were included, involving 572 patients. Four of these trials were only of modest methodological quality and one placebo-controlled trial was considered to be of good quality. None of the four placebo-controlled trials (sham ultrasound) could demonstrate statistically significant differences between true and sham ultrasound therapy for any outcome measure at seven to 14 days of follow-up. The pooled relative risk for general improvement was 1.04 (random effects model, 95% confidence interval 0.92 to 1.17) for the comparison between ultrasound and sham ultrasound. The differences between intervention groups were generally small, between zero and six per cent for most dichotomous outcomes. However, one trial reported relatively large differences for pain free status (20%) and swelling (25%) in favour of ultrasound treatment. REVIEWER'S CONCLUSIONS: The extent and quality of the available evidence for the effects of ultrasound therapy for acute ankle sprains is limited. The results of four placebo-controlled trials do not support the use of ultrasound in the treatment of ankle sprains. The magnitude of most reported treatment effects appeared to be small, and may be of limited clinical importance. As yet, only few trials are available and no conclusions can be made regarding an optimal and adequate dosage schedule for ultrasound therapy, and whether such a schedule would improve on the reported effectiveness of ultrasound for ankle sprains.


Asunto(s)
Traumatismos del Tobillo/terapia , Esguinces y Distensiones/terapia , Terapia por Ultrasonido , Humanos , Ensayos Clínicos Controlados Aleatorios como Asunto
14.
Tijdschr Diergeneeskd ; 126(20): 646-50, 2001 Oct 15.
Artículo en Holandés | MEDLINE | ID: mdl-11699432

RESUMEN

Seven commercially available colostrum replacers were tested for their ability to substitute for goat colostrum as a source of gammaglobulin for goat kids. One hundred kids were fed with goat colostrum or colostrum replacer after separation from their mothers at birth. Blood samples were taken from ten kids at birth, and from all kids at 48 hours after birth. Samples were used to measure the total protein content and gammaglobulin concentration of serum. Kids fed with goat colostrum had higher gammaglobulin concentrations than newborn kids or kids fed with replacer. For three replacers, the gammaglobulin concentrations were the same as those of newborn kids. For three other replacers, the gammablobulin concentrations were similar but higher than those of newborn kids. For one replacer, the levels of gammaglobulin were higher than those of in newborn kids and higher than those measured after feeding of the other replacers. None of the replacers was an adequate substitute for goat colostrum as a source of gammaglobulins.


Asunto(s)
Animales Lactantes/inmunología , Calostro/inmunología , Cabras/inmunología , gammaglobulinas/análisis , Alimentación Animal , Animales , Animales Lactantes/sangre , Calostro/metabolismo , Femenino , Alimentos Formulados/normas , Cabras/sangre , Inmunidad Materno-Adquirida , Factores de Tiempo , gammaglobulinas/metabolismo
15.
Occup Environ Med ; 57(7): 433-42, 2000 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-10854494

RESUMEN

OBJECTIVES: To systematically evaluate the available evidence on occupational risk factors of shoulder pain. METHODS: Relevant reports were identified by a systematic search of Medline, Embase, Psychlit, Cinahl, and Current Contents. The quality of the methods of all selected publications was assessed by two independent reviewers using a standardised checklist. Details were extracted on the study population, exposures (physical load and psychosocial work environment), and results for the association between exposure variables and shoulder pain. RESULTS: 29 Studies were included in the review; three case-control studies and 26 cross sectional designs. The median method score was 60% of the maximum attainable score. Potential risk factors related to physical load and included heavy work load, awkward postures, repetitive movements, vibration, and duration of employment. Consistent findings were found for repetitive movements, vibration, and duration of employment (odds ratio (OR) 1.4-46 in studies with method scores >/= 60%). Nearly all studies that assessed psychosocial risk factors reported at least one positive association with shoulder pain, but the results were not consistent across studies for either high psychological demands, poor control at work, poor social support, or job dissatisfaction. Studies with a method score >/=60% reported ORs between 1.3 and 4.0. Substantial heterogeneity across studies for methods used for exposure assessment and data analysis impeded statistical pooling of results. CONCLUSIONS: It seems likely that shoulder pain is the result of many factors, including physical load and the psychosocial work environment. The available evidence was not consistent across studies, however, and the associations were generally not strong. Future longitudinal research should evaluate the relative importance of each individual risk factor and the role of potential confounding variables-such as exposure during leisure time-to set priorities for the prevention of shoulder pain in occupational settings.


Asunto(s)
Exposición Profesional/efectos adversos , Dolor de Hombro/etiología , Sesgo , Estudios de Casos y Controles , Factores de Confusión Epidemiológicos , Estudios Transversales , Interpretación Estadística de Datos , Humanos , Factores de Riesgo
16.
Cochrane Database Syst Rev ; (2): CD001250, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-10796428

RESUMEN

BACKGROUND: Ultrasound is used in the treatment of a wide variety of musculoskeletal disorders. OBJECTIVES: To evaluate the effects of ultrasound therapy in the treatment of acute ankle sprains. SEARCH STRATEGY: MEDLINE and EMBASE up to December 1998 and databases of the Cochrane Rehabilitation and Related Therapies Field and Musculoskeletal Injuries Group were searched. This was supplemented with citation tracking, and contact with colleagues. Date of the most recent search: April 1999. SELECTION CRITERIA: Randomised or pseudo-randomised trials were included in the review if the following conditions were met: at least one study group was treated with active ultrasound; the study included patients with acute lateral ankle sprains; and outcome measures included general improvement, pain, swelling, functional disability, or range of motion. Final selection of papers was conducted by two independent reviewers. DATA COLLECTION AND ANALYSIS: Two reviewers independently assessed trial quality using a standardised checklist, and extracted data. Whenever possible, the results were analysed on an intention-to-treat basis. Fixed odds ratios together with 95% confidence intervals were calculated for dichotomous outcomes, and weighted or, where different scales were used, standardised mean differences together with 95% confidence intervals for continuous outcome measures. Pooling of data was undertaken where there was clinical homogeneity in terms of subjects, treatments, outcomes, and follow-up time points. MAIN RESULTS: The four included trials, involving 514 patients, were only of modest methodological quality. None of the three placebo-controlled trials (sham ultrasound) could demonstrate statistically significant differences between true and sham ultrasound therapy for any outcome measure at seven days of follow-up. The pooled odds ratio for general improvement was 1.19 (Peto fixed effects model, 95% confidence interval 0.73 to 1.93) for the comparison between ultrasound and sham ultrasound. The differences between intervention groups were generally small, between 0 and 6% for most dichotomous outcomes. However, one trial reported relatively large differences for pain free status (20%) and swelling (25%) in favour of ultrasound treatment. REVIEWER'S CONCLUSIONS: The extent and quality of the available evidence for the effects of ultrasound therapy for acute ankle sprains are limited. The results of three placebo-controlled trials do not support the use of ultrasound in the treatment of ankle sprains. The magnitude of most reported treatment effects appeared to be small, and may be of limited clinical importance. As yet, only few trials are available and no conclusions can be made regarding an optimal and adequate dosage schedule for ultrasound therapy, and whether such a schedule would improve on the reported effectiveness of ultrasound for ankle sprains.


Asunto(s)
Traumatismos del Tobillo/terapia , Esguinces y Distensiones/terapia , Terapia por Ultrasonido , Humanos
17.
Neurology ; 54(4): 914-20, 2000 Feb 22.
Artículo en Inglés | MEDLINE | ID: mdl-10690986

RESUMEN

OBJECTIVE: To determine characteristics of brain morphology in children and adolescents with neurofibromatosis type 1 and relate these characteristics to neuropsychological functioning. BACKGROUND: Neurofibromatosis type 1 is associated with numerous CNS abnormalities and cognitive impairment. Abnormal high signal intensity visible on brain MRI, brain tumors, and macrocephaly are common. Research into links between neuroanatomic and cognitive features has been inconclusive. METHODS: Fifty-two children and adolescents with neurofibromatosis type 1 were compared with 19 control subjects on several quantitative neuroanatomic and neuropsychological measures. RESULTS: Total brain volume, especially gray matter, was significantly greater for neurofibromatosis type 1 subjects than the control subjects. Group differences in the ratio of gray matter to white matter were more prominent in younger than in older subjects. Volume of gray matter in the subjects with neurofibromatosis type 1 was related to their degree of learning disability. Corpus callosum size was significantly larger for subjects in the neurofibromatosis type 1 group, and diminished performance on measures of academic achievement and visual-spatial and motor skills were associated with greater regional corpus callosum size. CONCLUSIONS: Neuroanatomic morphology and the developmental pattern of gray matter and white matter in subjects with neurofibromatosis type 1 differed from in control subjects. Some of these differences are related to the neuropsychological status of the neurofibromatosis type 1 group. We propose that delayed developmental apoptosis results in macrocephaly and a delay in the development of appropriate neuronal connections in children with neurofibromatosis type 1. We further propose that these morphologic delays are related to the cognitive profile of neurofibromatosis type 1.


Asunto(s)
Encéfalo/patología , Neurofibromatosis 1/patología , Neurofibromatosis 1/psicología , Adolescente , Distribución por Edad , Niño , Preescolar , Cuerpo Calloso/patología , Glioma/patología , Humanos , Lactante , Pruebas Neuropsicológicas , Neoplasias del Nervio Óptico/patología
18.
Ann Rheum Dis ; 58(5): 272-7, 1999 May.
Artículo en Inglés | MEDLINE | ID: mdl-10225810

RESUMEN

OBJECTIVES: To assess the interobserver agreement on the diagnostic classification of shoulder disorders, based on history taking and physical examination, and to identify the determinants of diagnostic disagreement. METHODS: Consecutive eligible patients with shoulder pain were recruited in various health care settings in the Netherlands. After history taking, two physiotherapists independently performed a physical examination and subsequently the shoulder complaints were classified into one of six diagnostic categories: capsular syndrome (for example, capsulitis, arthritis), acute bursitis, acromioclavicular syndrome, subacromial syndrome (for example, tendinitis, chronic bursitis), rest group (for example, unclear clinical picture, extrinsic causes) and mixed clinical picture. To quantify the interobserver agreement Cohen's kappa was calculated. Multivariate logistic regression analysis was applied to determine which clinical characteristics were determinants of diagnostic disagreement. RESULTS: The study population consisted of 201 patients with varying severity and duration of complaints. The kappa for the classification of shoulder disorders was 0.45 (95% confidence intervals (CI) 0.37, 0.54). Diagnostic disagreement was associated with bilateral involvement (odds ratio (OR) 1.9; 95% CI 1.0, 3.7), chronic complaints (OR 2.0; 95% CI 1.1, 3.7), and severe pain (OR 2.7; 95% CI 1.3, 5.3). CONCLUSIONS: Only moderate agreement was found on the classification of shoulder disorders, which implies that differentiation between the various categories of shoulder disorders is complicated. Especially patients with high pain severity, chronic complaints and bilateral involvement represent a diagnostic challenge for clinicians. As diagnostic classification is a guide for treatment decisions, unsatisfactory reproducibility might affect treatment outcome. To improve the reproducibility, more insight into the reproducibility of clinical findings and the value of additional diagnostic procedures is needed.


Asunto(s)
Artropatías/diagnóstico , Modalidades de Fisioterapia , Articulación del Hombro/patología , Articulación Acromioclavicular , Adolescente , Adulto , Anciano , Artritis/complicaciones , Artritis/diagnóstico , Bursitis/complicaciones , Bursitis/diagnóstico , Enfermedad Crónica , Diagnóstico Diferencial , Femenino , Humanos , Masculino , Persona de Mediana Edad , Variaciones Dependientes del Observador , Sensibilidad y Especificidad , Dolor de Hombro/etiología , Tendinopatía/complicaciones , Tendinopatía/diagnóstico
19.
Public Health Nutr ; 2(1A): 97-103, 1999 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-10933629

RESUMEN

OBJECTIVE: To explore the factors that influence attitudes and beliefs about the effects of body weight and physical activity on health. DESIGN: Cross-sectional survey using a face-to-face interview-assisted questionnaire. SETTING: The survey was conducted between March and April 1997 in the 15 member states of the EU. SUBJECTS: Approximately 1000 adults aged 15 years plus from each country were selected by quota-controlled sampling; the total sample was of 15,239 persons (7162 males and 8077 females). Data were weighted by population size for each country and by age, gender and regional distribution within countries. RESULTS: Overall 27% of men and 35% of women reported not engaging in any form of recreational activity; rates were highest in those with a primary-level education (37% men, 43% women) compared with tertiary-level education (20% men, 25% women). Recreational activity levels declined with age and tended to be lowest in those who were more physically active at work. Eighteen per cent of respondents believed that physical activity was one of the two greatest influences on health; 13% mentioned body weight, 38% mentioned food, 41% mentioned smoking and 33% mentioned stress. Logistic regression was used to assess for the effects of gender, age, educational level, body mass index (BMI), smoking status, activity level and country on beliefs that body weight and physical activity influenced health. Primary-educated, overweight, ex- and non-smoking women were most likely to mention body weight as an influence; young tertiary-educated, thinner, non-smoking and active males were most likely to mention physical activity. There was wide variation across Europe in reported behaviour and beliefs, which persisted after taking account of all of the other factors in the regression model. CONCLUSIONS: Relatively few people in some countries believed body weight and physical activity were important influences on health. Many people mentioned stress and it might be possible to use this interest to motivate changes in physical activity to relieve stress. It may be important to take a more integrated approach to activity patterns that consider the role of work and recreation. Although social and demographic factors were important, after adjusting for these factors there was still wide between-country variation in reported attitudes, beliefs and behaviour. This will need to be taken into account in any activity promotion campaigns.


Asunto(s)
Actitud Frente a la Salud , Peso Corporal , Unión Europea/estadística & datos numéricos , Ejercicio Físico/psicología , Adolescente , Adulto , Anciano , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Percepción Social
20.
Public Health Nutr ; 2(1A): 153-60, 1999 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-10933635

RESUMEN

OBJECTIVE: To examine the attitudes of consumers, in particular their perceived benefits and barriers to physical activity from all EU member states, and having a measure of prevailing levels of activity, inactivity and self-reported body weight and body shape. DESIGN: Cross-sectional survey using an interview-assisted face-to-face questionnaire. SETTING: The survey was conducted between March and April 1997 in the 15 member states of the EU. SUBJECTS: Overall, 15,239 EU subjects, classified according to sex, age (six levels) and highest level of education attained (primary, secondary or tertiary), completed the survey. Sample selection of subjects in each EU member state was quota-controlled to ensure they were nationally representative. RESULTS: The most important motivation for people to participate in physical activity is to maintain good health (42%), to release tension (30%) and to get fit (30%). The importance of the health argument is highest in older persons and in subjects with a primary education level. Only 13% of the EU population (16% of women, 10% of men) perceived losing weight as a benefit of physical exercise. The most important barriers to increase physical activity are work or study commitments (28%) and the subjects' belief that they are not 'the sporty type' (25%). There is considerable between-country variation in the answering pattern within the EU.


Asunto(s)
Actitud Frente a la Salud , Peso Corporal , Ejercicio Físico/psicología , Obesidad/prevención & control , Adolescente , Adulto , Anciano , Estudios Transversales , Dieta/tendencias , Unión Europea/estadística & datos numéricos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Percepción , Encuestas y Cuestionarios
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA
...