RESUMEN
BACKGROUND AND PURPOSE: The impact of various radiologic and clinical features on the long-term outcome in spinal dural arteriovenous fistulas is still unclear; thus, they are the purpose of this study. MATERIALS AND METHODS: We retrospectively analyzed our medical data base for all patients treated for spinal dural arteriovenous fistula in our institution between 2006 and 2016. Patient age, neurologic status at the time of diagnosis, the duration of symptoms from onset to diagnosis, and follow-up information were evaluated. The extent of medullary T2WI hyperintensity, intramedullary contrast enhancement, and elongation of perimedullary veins on MR imaging at the time of diagnosis were additionally analyzed. RESULTS: Data for long-term outcome analysis were available in 40 patients with a mean follow-up of 52 months (median, 50.5 months; range, 3-159 months). The mean age at the time of diagnosis was 69.27 ± 9 years (median, 71 years; range, 53-84 years) with a male predominance (n = 32; 80%). The mean duration of symptoms was 20.2 months (median, 10 months; range, 1-120 months). Shorter duration of symptoms at the time of diagnosis was significantly correlated with better outcome of symptoms (P < .05). CONCLUSIONS: Spinal dural arteriovenous fistulas are characterized by interindividually variable clinical presentations, which make a determination of specific predictors for long-term outcome more difficult. Fast and sufficient diagnosis might result in a better outcome after treatment. The diagnosis of spinal dural arteriovenous fistula remains markedly delayed, reflecting an ongoing lack of knowledge and awareness among treating physicians of this rare-but-serious disease.
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Malformaciones Vasculares del Sistema Nervioso Central/diagnóstico , Malformaciones Vasculares del Sistema Nervioso Central/terapia , Diagnóstico Tardío , Enfermedades de la Médula Espinal/diagnóstico , Enfermedades de la Médula Espinal/terapia , Anciano , Anciano de 80 o más Años , Femenino , Humanos , Masculino , Persona de Mediana Edad , Recuperación de la Función , Estudios Retrospectivos , Médula Espinal/irrigación sanguínea , Médula Espinal/patologíaRESUMEN
OBJECTIVE: Deep lumbosacral dural arteriovenous fistulas (lsDAVF) are rare and present serious diagnostic and treatment difficulties. In our current analysis we present our treatment strategy and the long-term clinical outcome of nineteen patients with lsDAVF. PATIENTS AND METHODS: We retrospectively analyzed our radiological and medical records for patients presenting with SDAVF between 1990 and 2018 at the University Hospital Aachen. We identified twenty patients with a lsDAVF. All patients were treated surgically. One patient died of pulmonary embolism three months after treatment and was excluded from our outcome analysis. Clinical data at time of admission, discharge, one year after discharge and at the last follow-up were evaluated according to modified Aminoff-Logue disability score (AL-score) for this analysis. RESULTS: Mean age was 65⯱â¯7 years (median, 67; range, 53-78), sixteen patients (84 %) were male. After surgery, four patients developed a recurrent fistula in the same shunt zone and were re-treated microsurgically. Follow-up data one year after treatment was available in 15 patients. No relevant changes in AL-score were observed within this period. For the long-term follow-up analysis, data of 13 patients were available; 38.5 % of patients developed late functional deterioration. CONCLUSION: In our cohort, patients with deep lumbosacral dural arteriovenous fistula had a higher risk of early recurrence compared to patients with thoracolumbar SDAVF, with a considerable percentage of late functional deterioration. Thus strict clinical and radiologic long-term follow-up examinations are recommended in those patients.
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Fístula Arteriovenosa/cirugía , Malformaciones Vasculares del Sistema Nervioso Central/cirugía , Microcirugia/métodos , Procedimientos Neuroquirúrgicos/métodos , Anciano , Fístula Arteriovenosa/diagnóstico por imagen , Malformaciones Vasculares del Sistema Nervioso Central/diagnóstico por imagen , Femenino , Humanos , Vértebras Lumbares , Región Lumbosacra , Angiografía por Resonancia Magnética , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Recurrencia , Reoperación , SacroRESUMEN
BACKGROUND AND PURPOSE: The purpose of this study was to discuss the clinical and radiologic characteristics of spinal epidural arteriovenous fistulas (SEAVF) and demonstrate their specific angiomorphology in a single-center series. MATERIALS AND METHODS: Thirteen consecutive patients were diagnosed with SEAVF at RWTH Aachen University Hospital between 2006 and 2018 and were included in this study. All patients had MR imaging and DSA before treatment; 10 of these 13 patients received contrast-enhanced MRA (CE-MRA). RESULTS: The mean patient age was 72 ± 8 years. Paraparesis was present in 12 (92%) patients. Sphincter dysfunction and sensory symptoms were observed in 7 (54%) and 6 (46%) patients, respectively. The mean duration of symptoms was 6 ± 8 months. Congestive myelopathy on MR imaging was present in all patients. Prominent arterialized perimedullary veins were demonstrated in only 3 cases. CE-MRA revealed arterialized perimedullary veins and an arterialized epidural pouch in 9/10 (90%) patients, mostly located ventrolaterally. DSA demonstrated a multisegmental extension of the arterialized ventrolateral epidural pouch in 6 (46%) cases. An intradural radicular drainage vein was localized distant from the original fistula point in 3 (23%) patients. CONCLUSIONS: Congestive myelopathy with an acute/subacute clinical course was the dominant finding in spinal epidural arteriovenous fistulas. CE-MRA is a powerful diagnostic tool for identifying arterialized perimedullary veins as well as an arterialized epidural pouch. While arterialized perimedullary veins frequently present with only mild enlargement and elongation in spinal epidural arteriovenous fistulas, the arterialized epidural pouch is frequently located ventrolaterally and may extend over several vertebral levels. DSA remains the criterion standard to precisely visualize a spinal epidural arteriovenous fistula and its intradural radicular drainage vein, which may be located distant from the fistulous point.
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Fístula Arteriovenosa/diagnóstico por imagen , Fístula Arteriovenosa/patología , Neuroimagen/métodos , Anciano , Anciano de 80 o más Años , Angiografía de Substracción Digital/métodos , Fístula Arteriovenosa/complicaciones , Espacio Epidural/diagnóstico por imagen , Espacio Epidural/patología , Femenino , Humanos , Angiografía por Resonancia Magnética/métodos , Imagen por Resonancia Magnética/métodos , Masculino , Persona de Mediana Edad , Enfermedades de la Médula Espinal/etiologíaRESUMEN
AIM: The differentiation between epileptic and non-epileptic episodes can be challenging. Our aim was to compare lactate, anion gap (AG), bicarbonate and the Denver Seizure Score (DSS) as point-of-care test (POCT) markers for episodes of transient alterations of consciousness. METHODS: The blood serum parameters were drawn at arrival in the emergency department (ED) within 2 h of the episode. After calculating AG and DSS values, the four parameters were compared retrospectively between patients with generalized tonic-clonic seizures (GTCS) (n = 165) and patients with other disorders of consciousness [syncopes (n = 43), and psychogenic non-epileptic seizures (n = 15)]. Additionally, we compared all values among men and women. RESULTS: In GTCS patients, all four parameters differed significantly compared to non-epileptic episode patients (p < 0.001). Serum lactate showed significant additional benefit over the remaining values, with an AUC of 0.947 (95% CI 0.92-0.975) and a high sensitivity and specificity for an optimal cut-off value of 2.45 mmol/l. For DSS, the AUC was 0.857 (95% CI 0.808-0.906; cut-off: 0.35), and for AG 0.836 (95% CI 0.783-0.889; cut-off: 12.45 mmol/l). In the case of serum bicarbonate, the AUC was 0.831 (95% CI 0.775-0.886; cut-off: 22.75 mmol/l). In the sex-dependent comparison, the results were similar. Men showed more significant differences in the compared values than women. CONCLUSIONS: Serum lactate is best suited as POCT marker in the differential diagnosis of epileptic and non-epileptic episodes and is superior to AG, DSS and bicarbonate. The differences among sexes may pose a challenge in their implementation and interpretation.
Asunto(s)
Equilibrio Ácido-Base , Bicarbonatos/sangre , Análisis de los Gases de la Sangre/normas , Trastornos de la Conciencia/diagnóstico , Epilepsia Tónico-Clónica/diagnóstico , Ácido Láctico/sangre , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Trastornos de la Conciencia/sangre , Diagnóstico Diferencial , Epilepsia Tónico-Clónica/sangre , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Sensibilidad y Especificidad , Adulto JovenRESUMEN
BACKGROUND: Laboratory parameters can help in the differential diagnostics of acute episodes of transient loss of consciousness. Especially serum lactate and serum creatine kinase (CK) levels may provide valuable hints to distinguish generalized tonic-clonic seizures (GTCS) from syncope. MATERIAL AND METHODS: Serum lactate levels at admission and CK levels 10-48â¯h after the episodes that led to admission were compared between patients with GTCS (nâ¯= 30) and those with syncope (nâ¯= 15). In addition, sensitivity and specificity of lactate and CK as diagnostic markers for syncope and GTCS were determined. RESULTS: The serum lactate and serum CK levels were significantly increased in patients with GTCS as compared to syncope patients (serum lactate: pâ¯< 0.001; CK: pâ¯< 0.005). The area under the curve (AUC) for serum lactate as an indicator for GTCS was 0.94 (95% confidence interval [CI] 0.88-1.0). For CK the receiver operating characteristics (ROC) analysis produced an AUC of only 0.77 (95% CI: 0.63-0.9). CONCLUSION: The determination of the lactate value as point-of-care diagnostics appears to be highly relevant in the rapid clarification of unclear episodes with transient loss of consciousness. The CK level at follow-up is also suitable for distinguishing GTCS from syncope but is inferior to the serum lactate value.
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Creatina Quinasa , Lactatos , Convulsiones , Inconsciencia , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Creatina Quinasa/sangre , Femenino , Humanos , Lactatos/sangre , Masculino , Persona de Mediana Edad , Convulsiones/sangre , Convulsiones/diagnóstico , Síncope/sangre , Síncope/diagnóstico , Inconsciencia/sangre , Inconsciencia/diagnóstico , Adulto JovenRESUMEN
BACKGROUND AND PURPOSE: Spinal dural arteriovenous fistulas located in the deep lumbosacral region are rare and the most difficult to diagnose among spinal dural arteriovenous fistulas located elsewhere in the spinal dura. Specific clinical and radiologic features of these fistulas are still inadequately reported and are the subject of this study. MATERIALS AND METHODS: We retrospectively evaluated all data of patients with spinal dural arteriovenous fistulas treated and/or diagnosed in our institution between 1990 and 2017. Twenty patients with deep lumbosacral spinal dural arteriovenous fistulas were included in this study. RESULTS: The most common neurologic findings at the time of admission were paraparesis (85%), sphincter dysfunction (70%), and sensory disturbances (20%). Medullary T2 hyperintensity and contrast enhancement were present in most cases. The filum vein and/or lumbar veins were dilated in 19/20 (95%) patients. Time-resolved contrast-enhanced dynamic MRA indicated a spinal dural arteriovenous fistula at or below the L5 vertebral level in 7/8 (88%) patients who received time-resolved contrast-enhanced dynamic MRA before DSA. A bilateral arterial supply of the fistula was detected via DSA in 5 (25%) patients. CONCLUSIONS: Clinical symptoms caused by deep lumbosacral spinal dural arteriovenous fistulas are comparable with those of spinal dural arteriovenous fistulas at other locations. Medullary congestion in association with an enlargement of the filum vein or other lumbar radicular veins is a characteristic finding in these patients. Spinal time-resolved contrast-enhanced dynamic MRA facilitates the detection of the drainage vein and helps to localize deep lumbosacral-located fistulas with a high sensitivity before DSA. Definite detection of these fistulas remains challenging and requires sufficient visualization of the fistula-supplying arteries and draining veins by conventional spinal angiography.
Asunto(s)
Angiografía de Substracción Digital/métodos , Malformaciones Vasculares del Sistema Nervioso Central/diagnóstico por imagen , Angiografía por Resonancia Magnética/métodos , Médula Espinal/anomalías , Médula Espinal/diagnóstico por imagen , Adulto , Anciano , Femenino , Humanos , Región Lumbosacra , Masculino , Persona de Mediana Edad , Estudios RetrospectivosRESUMEN
PURPOSE: The diagnostic classification of disorders of consciousness is often challenging, particularly the distinction between epileptic and non-epileptic seizures. The aim of the study was to examine serum lactate as a diagnostic marker of transient loss of consciousness. METHOD: Serum lactate levels in blood samples drawn within 2h of the event were compared retrospectively between patients with generalized tonic-clonic seizures (n=195) and patients with other seizures (syncopes [n=52], psychogenic non-epileptic seizures [n=17], and complex focal seizures [n=37]), respectively. RESULTS: Serum lactate in patients with generalized tonic-clonic seizures was significantly (p<0.001, Mann-Whitney-U test) increased in comparison to other forms of seizure incidences. The area under the ROC-curve was 0.94 (95% CI 0.91-0.96). For a cut-off concentration of 2.45mmol/l, the sensitivity was 0.88 and the specificity 0.87. CONCLUSIONS: Serum lactate levels in the acute diagnosis were an excellent biomarker for the discrimination of generalized seizures from psychogenic non-epileptic and syncopal events, corroborating its importance for the standard work-up of acute disturbances of consciousness.
Asunto(s)
Ácido Láctico/sangre , Trastornos Psicofisiológicos/sangre , Convulsiones/sangre , Inconsciencia/sangre , Adulto , Anciano , Anciano de 80 o más Años , Biomarcadores/sangre , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Síncope/sangreRESUMEN
In clinical practice, secondary infections of the central nervous system (CNS) represent rare yet severe complications of their respective primary infections. In this case report, we describe a 22-year-old patient with a medical history of Asthma bronchiale, who developed significant neurological deficits after a respiratory infection. The neurological symptoms progressed despite antibiotic therapy with vancomycin, ampicillin and ceftriaxone. The patient's cerebrospinal fluid and a cranial magnetic resonance imaging (MRI) furnished evidence of acute meningoencephalitis. Microbiological assessment confirmed an acute mycoplasma pneumonia infection. Changing the patient's antibiotic regimen to minocycline and prednisolone led to significant clinical improvement. Pathomechanisms and therapeutic options to treat meningoencephalitis will be discussed in the following.
Asunto(s)
Meningoencefalitis/etiología , Mycoplasma pneumoniae , Neumonía por Mycoplasma/complicaciones , Ampicilina/uso terapéutico , Antibacterianos/uso terapéutico , Asma/complicaciones , Ceftriaxona/uso terapéutico , Femenino , Humanos , Imagen por Resonancia Magnética , Meningoencefalitis/tratamiento farmacológico , Meningoencefalitis/microbiología , Neumonía por Mycoplasma/tratamiento farmacológico , Neumonía por Mycoplasma/microbiología , Vancomicina/uso terapéutico , Adulto JovenRESUMEN
The kinematics of hand transport and grasp formation when reaching for and grasping cubes of different sizes were investigated in subjects with blepharospasm, subjects with torticollis and healthy subjects. Patients scaled peak grasp aperture accurately to object size, reflecting accurate sensorimotor integration of the intrinsic object characteristics. Likewise, the timing of peak grasp aperture in relation to the time of hand transport did not differ between patients and controls. In contrast, patients with blepharospasm and torticollis produced longer movement times and smaller peak velocities of hand transport. Increased movement times and slowed hand transport correlated significantly with symptom severity as assessed by the Unified Dystonia Rating Scale. The observation that the processing of peak grasp aperture was unaffected by blepharospasm or torticollis does not support the current concept of impaired sensorimotor integration. The slowing of hand transport appears to reflect a strategic response to compensate for insecurities in the execution of reaching movements to be found in focal dystonia of the face and neck.
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Trastornos Distónicos/patología , Trastornos Distónicos/fisiopatología , Cara/fisiopatología , Fuerza de la Mano/fisiología , Cuello/fisiopatología , Adulto , Anciano , Anciano de 80 o más Años , Análisis de Varianza , Fenómenos Biomecánicos , Lateralidad Funcional , Humanos , Persona de Mediana Edad , Desempeño Psicomotor , Índice de Severidad de la Enfermedad , Estadística como AsuntoRESUMEN
Drug-induced seizures are in view of a constantly ageing population and increasingly frequent polypharmacotherapy an increasing problem in daily routine praxis. Identification of potentially seizure-inducing drugs may help generating risk profiles for individual patients. Drug-induced seizures have often been seen as a complication of psychopharmacological therapy, but its occurrence has also been described in response to a great diversity of compounds such as antibiotics, sympathomimetics and anaesthetics. The present article outlines a synopsis of the most prevalent seizure-inducing drugs as well as strategies how to deal with a patient suffering from a drug-induced seizure.
Asunto(s)
Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Convulsiones/inducido químicamente , Analgésicos Opioides/efectos adversos , Anestésicos/efectos adversos , Antibacterianos/efectos adversos , Anticonvulsivantes/efectos adversos , Antidepresivos/efectos adversos , Antipsicóticos/efectos adversos , Baclofeno/efectos adversos , Estimulantes del Sistema Nervioso Central/efectos adversos , Medios de Contraste/efectos adversos , Humanos , Relajantes Musculares Centrales/efectos adversos , Inhibidores de Fosfodiesterasa/efectos adversos , Convulsiones/epidemiologíaRESUMEN
We report on the case of a 63-year-old patient with a meningoencephalitis, presenting itself with headache and a general neuropsychological retardation. Additionally, a reddening and swelling of both auricles could be seen. Magnetic resonance imaging showed confluent, contrast-uptaking lesions. In the cerebrospinal fluid an aseptic lymphocytic pleocytosis was found. A biopsy of the ear revealed a chronic lymphoplasmacellular inflammatory reaction. We diagnosed a relapsing polychrondritis, an inflammatory disease of the cartilage, which can in rare cases affect the central nervous system. Typically, the patients complain about red swollen ears, the "red puffy ear sign". After initiation of steroid and azathioprin therapy the patient recovered fully.
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Oído Externo/patología , Meningoencefalitis/diagnóstico , Meningoencefalitis/patología , Policondritis Recurrente/diagnóstico , Policondritis Recurrente/patología , Antiinflamatorios/uso terapéutico , Azatioprina/uso terapéutico , Biopsia , Cefalea/etiología , Humanos , Inmunosupresores/uso terapéutico , Leucocitosis/líquido cefalorraquídeo , Imagen por Resonancia Magnética , Masculino , Persona de Mediana Edad , Prednisolona/uso terapéuticoRESUMEN
Drug-induced tremor is an important differential diagnosis for tremor syndromes. In view of a constantly ageing population and increasingly frequent polypharmacotherapy, identification of potentially tremor-inducing drugs may help generating risk profiles for individual patients. Drug-induced tremor has often been seen as a complication of antipsychotic therapy, but its occurrence has also been described in response to a great diversity of compounds such as antidepressants, sympathomimetics, antiarrhythmics, antiepileptics and other drugs. The present article presents a synopsis of the most prevalent tremor-inducing drugs as well as strategies to overcome drug-induced tremor, either by replacement of the causative drug or by symptomatic therapies.
Asunto(s)
Temblor/inducido químicamente , Agonistas de Receptores Adrenérgicos beta 2/efectos adversos , Antagonistas Adrenérgicos beta/efectos adversos , Animales , Anticonvulsivantes/efectos adversos , Antidepresivos/efectos adversos , Antipsicóticos/efectos adversos , Broncodilatadores/efectos adversos , Cimetidina/efectos adversos , Antagonistas de los Receptores H2 de la Histamina/efectos adversos , Humanos , Inmunosupresores/efectos adversos , Lamotrigina , Compuestos de Litio/efectos adversos , Pindolol/efectos adversos , Teofilina/efectos adversos , Temblor/terapia , Triazinas/efectos adversos , Ácido Valproico/efectos adversosRESUMEN
AIM: Imaging of presynaptic dopamine transporters (DAT) by single-photon emission computed tomography (SPECT) and [(123)I]FP-CIT is an established method for differentiating between neurodegenerative and non-neurodegenerative parkinsonism. Whereas a region-of-interest (ROI) analysis is the method of choice for analyzing [(123)I]FP-CIT SPECT studies, visual image interpretations can also provide highly accurate results. The present study was undertaken to validate a visual reading system for parametric volume of distribution (DVR) [(123)I]FP-CIT SPECT images that combines the quantitative nature of ROI analyses and the simplicity of visual readings. METHODS: A 9-step linear visual rating template for semi-quantitative DVR ratings of caudate nucleus and putamen was developed (VRDVR). The conventional 4-step visual reading system that is mainly based on the [(123)I]FP-CIT uptake pattern was used for comparison (VRP method). Six independent observers retrospectively rated the [(123)I]FP-CIT scans of 30 consecutive parkinsonism and tremor patients (N.=16 neurodegenerative, N.=14 non-neurodegenerative) using VRDVR and VRP. In addition, a highly trained investigator performed manual ROI analyses. RESULTS: The ROI analysis provided complete separation of both patient groups by comparing the lower DAT binding of both putamina (i.e., putamen contralateral to clinically most affected side in neurodegenerative parkinsonism). Using VRP, the two most experienced observers correctly classified all patients while 20 false-positive ratings occurred in the less experienced observers (mean area under the receiver operating characteristic curve [AUCROC] of all observers 0.93±0.07). The VRDVR ratings of the two most experienced observers did not overlap between patient groups, although at different VRDVR score cut-offs. Using the same VRDVR score cut-off for all observers, only six false-negative and one false-positive ratings occurred in total (AUCROC 0.99±0.01). Inter-observer agreement was good for VRP and VRDVR. Moreover, semi-quantitative VRDVR and quantitative ROI analyses showed a strong correlation in all observers (Spearman's rho, 0.85-0.91). CONCLUSIONS: The proposed VRDVR method offers a very promising visual analysis method for [(123)I]FP-CIT SPECT studies in parkinsonism. The accuracy of VRDVR readings was found to be superior to conventional VRP, while it provided a diagnostic accuracy in less experienced observers that is comparable to manual ROI analyses by a highly trained investigator.
Asunto(s)
Trastornos Parkinsonianos/diagnóstico por imagen , Tomografía Computarizada de Emisión de Fotón Único , Anciano , Encéfalo/diagnóstico por imagen , Encéfalo/metabolismo , Núcleo Caudado/diagnóstico por imagen , Proteínas de Transporte de Dopamina a través de la Membrana Plasmática/metabolismo , Humanos , Radioisótopos de Yodo , Persona de Mediana Edad , Variaciones Dependientes del Observador , Trastornos Parkinsonianos/diagnóstico , Trastornos Parkinsonianos/metabolismo , Putamen/diagnóstico por imagen , Radiofármacos , Estudios Retrospectivos , TropanosRESUMEN
The wrist drop, also called carpoptosis or drop hand, is a common clinical presentation in case of peripheral damage to the radial nerve. But what about the picture of a bilateral finger/wrist drop?! We report the case of a 61-year-old female patient who was admitted to the hospital for myocardial infarction. Subsequently she developed a right dominant bilateral wrist drop. Further neurological examination revealed a positive Wartenberg sign pointing towards a central motoric dysfunction. The following native cerebral CT scan demonstrated bilateral hypodense lesions in both hand knobs in the precentral gyri. Subsequent MRI confirmed acute cerebral infarction in these two but also several other, clinically silent, locations. Further diagnostic work-up revealed a hypokinetic cardiac apex suggesting cardiac embolism to be the cause for cerebral thrombembolism and the clinically leading symptom of right-dominant bilateral finger/wrist drop. Besides the case presentation also the differential diagnosis and clinical test for diagnostic work-up of wrist drops are presented and discussed.
Asunto(s)
Sistema Nervioso Central/patología , Nervios Periféricos/patología , Neuropatía Radial/patología , Muñeca/patología , Angiografía , Infarto Cerebral/complicaciones , Diagnóstico Diferencial , Electrodiagnóstico , Femenino , Humanos , Embolia Intracraneal/complicaciones , Imagen por Resonancia Magnética , Persona de Mediana Edad , Infarto del Miocardio/complicaciones , Examen Neurológico , Neuropatía Radial/diagnóstico , Tomografía Computarizada por Rayos XRESUMEN
Psychogenic tremor is the most common psychogenic movement disorder. Its prognosis is widely held to be poor and strongly depends on the patient's insight into the psychogenicity of the syndrome. The clinical value of transcranial magnetic stimulation (TMS) for (i) establishing the diagnosis with a high level of certainty, (ii) modulating symptom severity and (iii) facilitating patients' insight into psychogenicity was tested in 11 patients with psychogenic tremor of the upper limb. After explaining the psychogenic origin of the syndrome and providing a neurobiological model, 30 TMS pulses were applied over the hand area of the primary motor cortex contralateral to the affected hand(s) at a rate of 0.2 Hz. 15 pulses were administered at intensities of 120 % and 140 % of the resting motor threshold, respectively. Kinematic motion analysis was used to document the effectiveness of the TMS procedure. All patients met the diagnostic criteria of conversion disorder. Time elapsed since symptom onset was on average 48 to 57 months. Tremor affected both hands in 8 patients, one patient had additional head tremor. The TMS procedure caused a significant reduction of tremor frequency and thus established the diagnosis of documented psychogenic tremor according to the criteria proposed by Fahn and Williams (1988) in each patient. The duration of symptom relief was transient in 7 patients, 4 patients had lasting symptom relief. The present pilot study demonstrates that TMS is a helpful tool to (i) establish the diagnosis of psychogenic hand tremor with a high level of certainty, (ii) reduce tremor intensity and (iii) facilitate the patient's insight into the psychogenic origin of the syndrome as a prerequisite to obtain adherence to psychotherapy.
Asunto(s)
Trastornos Psicofisiológicos/etiología , Trastornos Psicofisiológicos/terapia , Estimulación Magnética Transcraneal , Temblor/etiología , Temblor/terapia , Adulto , Fenómenos Biomecánicos , Femenino , Lateralidad Funcional/fisiología , Mano/fisiología , Cabeza/fisiología , Humanos , Masculino , Trastornos Mentales/complicaciones , Persona de Mediana Edad , Modelos Neurológicos , Corteza Motora/fisiología , Proyectos Piloto , Trastornos Psicofisiológicos/psicología , Psicoterapia , Estimulación Magnética Transcraneal/efectos adversos , Resultado del Tratamiento , Temblor/psicología , Extremidad Superior/fisiología , Adulto JovenRESUMEN
AIM: The effect of electrical somatosensory stimulation on motor performance of the affected hand was investigated in 12 chronic subcortical stroke subjects. METHODS: Subjects performed index finger and hand tapping movements as well as reach-to-grasp movements with both the affected and unaffected hand prior to (baseline conditions) and following (1) 2 h of electrical somatosensory stimulation (trains of five pulses at 10 Hz with 1 ms duration delivered at 1 Hz with an intensity on average 60% above the individual somatosensory threshold) of the median nerve of the affected hand or (2) 2 h of idle time on separate occasions at least 1 week apart. The order of sessions was counterbalanced across subjects. RESULTS: Somatosensory stimulation of the median nerve of the affected hand, but not a period of idle time, enhanced the frequency of index finger and hand tapping movements and improved the kinematics of reach-to-grasp movements performed with the affected hand, compared with baseline. Somatosensory stimulation did not impact on motor performance of the unaffected hand. DISCUSSION: The data suggest that electrical somatosensory stimulation may improve motor function of the affected hand after stroke; however, further studies are needed to test if the implementation of somatosensory stimulation in rehabilitation of hand function also impacts on manual activities of daily life after stroke.
Asunto(s)
Fenómenos Biomecánicos , Mano/inervación , Infarto de la Arteria Cerebral Media/rehabilitación , Nervio Mediano/fisiopatología , Trastornos Psicomotores/rehabilitación , Estimulación Eléctrica Transcutánea del Nervio , Anciano , Enfermedad Crónica , Femenino , Humanos , Infarto de la Arteria Cerebral Media/fisiopatología , Masculino , Persona de Mediana Edad , Destreza Motora/fisiología , Trastornos Psicomotores/fisiopatologíaRESUMEN
Psychogenic tremor is the most common psychogenic movement disorder and accounts for up to 40 % of all psychogenic movement disorders. Patients suffering from psychogenic tremor may show positive clinical criteria like acute onset, distractibility, inconsistent frequency and amplitude of tremor or an intermittent occurrence. Moreover, there exist a few supportive clinical tests and diagnostic tools, which help to suggest a psychogenic origin of the disease, e. g., electromyographic or kinematic recordings. In this review the clinical presentation of psychogenic tremor and diagnostic approaches are discussed. In addition, novel therapeutic approaches, e. g., application of transcranial magnetic stimulation techniques are introduced.
Asunto(s)
Trastornos Somatomorfos/diagnóstico , Trastornos Somatomorfos/terapia , Temblor/diagnóstico , Temblor/terapia , Diagnóstico Diferencial , Humanos , Examen Neurológico , Psicotrópicos/uso terapéutico , Trastornos Somatomorfos/complicaciones , Trastornos Somatomorfos/tratamiento farmacológico , Temblor/tratamiento farmacológico , Temblor/etiologíaRESUMEN
We report on a 41-year old woman with prolonged comatose unresponsiveness following traumatic head injury. Structural MRI showed bilateral midbrain damage and ventriculomegalia. Functional MRI revealed robust cortical responses to visual, auditory and tactile stimulation. Speech stimuli moreover consistently elicited activation in Broca's and Wernicke's areas. Familiar speakers and direct addressing evoked significantly stronger amygdala activation than unfamiliar speakers and neutral phrases. This study hence demonstrates the potential of functional neuroimaging in the investigation of residual higher cortical functions in unresponsive comatose patients.