The efficacy of "IOL-Vip Revolution" telescopic intraocular lens in age-related macular degeneration cases with senile cataract.

PURPOSE: To evaluate the efficacy of the IOL-Vip Revolution telescopic intraocular lens in age-related macular degeneration patients. METHODS: A total of 13 eyes of 12 age-related macular degeneration patients with senile cataract were enrolled. Selection of the patients was done by means of a low vision diagnostic and rehabilitative program (IOL-Vip software) that evaluates residual visual function. After standard phacoemulsification surgery, the incision site was enlarged and the IOL-Vip Revolution system was implanted in the capsular bag. The outcome measures were best corrected visual acuity, contrast sensitivity, anterior chamber depth, endothelial cell density, central corneal thickness, and quality-of-life questionnaire. RESULTS: The mean age of the subjects was 72.3 ± 8.5 years. The mean positive power of the intraocular lens was 59 ± 2 D and the negative intraocular lens power was standard (-46 D). Pre- and postoperative best corrected visual acuity were 1.08 ± 0.14 and 0.81 ± 0.16 logMAR in the operated eye and 1.13 ± 0.36 and 1.01 ± 0.40 logMAR in the unoperated eye, respectively. The best corrected visual acuity was increased significantly in both operated and unoperated eyes (p = 0.005 and 0.021, respectively). Quality of life and anterior chamber depth increased significantly (p = 0.018 and 0.008, respectively), while endothelial cell density decreased (p = 0.002). No significant differences were detected in central corneal thickness or contrast sensitivity (p = 0.133 and 0.684, respectively). CONCLUSION: The results showed that IOL-Vip Revolution telescopic intraocular lens is a promising treatment option in age-related macular degeneration patients. The rehabilitation program may have an important role in the restored clinical results, which also provided visual improvement in the unoperated eyes.

The effects of Valsalva manoeuvre on Ocular Response Analyzer measurements.

BACKGROUND: The aim was to evaluate the effects of the Valsalva manoeuvre on Ocular Response Analyzer (ORA) measurements. METHODS: A total of 152 eyes of 76 healthy individuals were included. The biomechanical properties of cornea, including corneal hysteresis (CH), corneal resistance factor (CRF) and intraocular pressure (IOP) parameters, namely, cornea compensated IOP (IOPcc) and Goldmann correlated IOP (IOPg) as measured with ORA were obtained before and during the Valsalva manoeuvre. Wilcoxon test for group analysis, Mann-Whitney test for intergroup analysis, Generalized Estimating Equation, and Spearman's test for correlation analysis were used. RESULTS: The mean age of the 76 subjects (52 female) was 34.18 ± 10.20 years (range, 21 to 58 years). The mean IOPcc was 14.50 ± 0.30 mmHg before and 19.80 ± 0.60 mmHg during the Valsalva manoeuvre (p < 0.001). The mean IOPg before the Valsalva manoeuvre was 15.02 ± 0.33 mmHg and during was 20.18 ± 0.63 mmHg (p < 0.001). The mean corneal hysteresis was 11.40 ± 0.15 mmHg before Valsalva manoeuvre, and 10.60 ± 0.16 mmHg during Valsalva manoeuvre (p < 0.001). Pre-Valsalva manoeuvre mean corneal resistance factor was 11.97 ± 0.16 mmHg, whereas during the Valsalva manoeuvre, the mean corneal resistance factor was 12.06 ± 0.20 mmHg (p < 0.001). There was no correlation between age and either pre- or during-Valsalva manoeuvre measurements. The change in IOPcc and corneal hysteresis before and during Valsalva manoeuvre showed no intersexual difference; however, IOPg and corneal resistance factor change before and during Valsalva manoeuvre were significantly higher in male subjects. A negative correlation between pre-Valsalva manoeuvre corneal hysteresis and pre- and during-corneal resistance factor difference (r = -0.167) was detected. CONCLUSIONS: Valsalva manoeuvre causes a statistically significant increment in IOPcc, IOPg and corneal resistance factor and statistically significant decrement in corneal hysteresis. For this reason, to obtain reliable results, ORA measurements should be performed in suitable positions and with clothes that do not increase thoracic or abdominal pressure.