RESUMEN
BACKGROUND & AIMS: Whether maintaining optimal remnant cholesterol (RC) levels later in life may improve metabolic dysfunction-associated steatotic liver disease (MASLD) outcomes remained ambiguous. This study aimed to investigate the relationship between RC and MASLD in the elderly Chinese population. METHODS: A total of 131,868 subjects aged ≥ 65 years were included in this study. The association of RC with MASLD, and severity of MASLD was analyzed by logistic regression. In addition, stratified analysis was conducted to test the potential interaction. RESULTS: MASLD prevalence and RC concentration decreased with age. After adjustment for possible confounders, the odds ratio of MASLD at the highest quartile of RC compared to the lowest quartile was 1.587(95% CI: 1.524-1.652), and this effect remained in MASLD with liver fibrosis. Stratified analysis showed a more prominent effect on the MASLD in males, those aged 65-69 years, those without central obesity, those with diabetes, and normal level of total cholesterol, low-density lipoprotein cholesterol (Pfor interaction<0.05). CONCLUSIONS: In the elderly subset of the Chinese population, higher RC levels achieved a significant risk effect against MASLD. More RC monitoring should be given to older for the prevention and intervention of MASLD.
RESUMEN
It is generally difficult to predict fractures of low-permeability reservoirs under high confining pressures by data statistical method and simplified strain energy density method. In order to establish a series of geomechanical models for the prediction of multi-scale fractures in brittle tight sandstones, firstly, through a series of rock mechanics experiments and CT scanning, we determined 0.85 σc as the key thresholds for mass release of elastic strain energy and bursting of micro-fractures. A correlation between fracture volume density and strain energy density under uniaxial stress state was developed based on the Theory of Geomechanics. Then using the combined Mohr-Coulomb criterion and Griffith's criterion and considering the effect of filling degree in fractures, we continued to modify and deduce the mechanical models of fracture parameters under complex stress states. Finally, all the geomechanical equations were loaded into the finite element (FE) platform to quantitatively simulate the present-day 3-D distributions of fracture density, aperture, porosity, permeability and occurrence based on paleostructure restoration of the Keshen anticline. Its predictions agreed well with in-situ core observations and formation micro-imaging (FMI) interpretations. The prediction results of permeability were basically consistent with the unobstructed flow distributions before and after the reservoir reformation.
