[Primary natural killer/T cell lymphoma of the lung: two cases report and clinical analysis].

OBJECTIVE: To describe the clinical and pathological features of primary NK/T cell lymphoma of the lung. METHODS: Two cases of primary NK/T cell lymphoma of the lung were reported, and the clinical, radiological and pathological characteristics of the disease were discussed with literature review of 3 cases. RESULTS: Most patients presented with fever, cough and dyspnea, and antibiotics were ineffective. Radiographic findings included solitary or multiple nodules and consolidation, unilateral orbilateral pleural effusions (4/5), without hilar or mediastinal adenopathy. Ebstein-Barr virus was positive in cases patients (3/5). Histopathology revealed a great deal of abnormal lymphocyte infiltration, which were angio-centric with marked tissue putrescence and angio-destruction. Immunophenotyping showed CD56(+), CD3(+), perform (+), T-cell intracytoplasmic antigen-1(+) and/or GranB(+), but CD20(-). Most patients died of respiratory failure in half a year (4/5). CONCLUSION: Primary NK/T cell lymphoma of the lung is rare, but should be considered when patients present with lung shadows and fever non-responsive to antibiotics, decreased WBC and increased LDH.

[A high-resolution CT and pathological study of nonspecific interstitial pneumonia].

OBJECTIVE: To describe the characteristics of high-resolution CT(HRCT) findings of nonspecific interstitial pneumonia (NSIP) and the correlation with pathological changes. METHODS: The HRCT features of 9 cases (3 men and 6 women) of histopathologically confirmed NSIP were retrospectively analyzed and correlated with the pathological findings. RESULTS: The predominant HRCT features, found in all the cases, were bilaterally patchy areas of ground-glass opacity with or without areas of consolidation. Irregular linear opacities, traction bronchiectasis, and thickening of bronchovascular bundles were also frequently seen. The abnormalities were distributed over the peripheral zones of the middle and lower lungs in most cases. Honeycombing was not a feature in all the cases. Areas of ground-glass opacity with or without irregular linear opacity or traction bronchiectasis corresponded pathologically to areas of interstitial thickening caused by varying degrees of interstitial inflammation and fibrosis showing temporal uniformity. Areas of consolidation were associated with extensive collagen-type interstitial fibrosis and mild interstitial inflammation at the biopsy sites, and occasionally represented the areas of bronchiolitis obliterans organizing pneumonia, foamy cell collections in alveolar spaces, or microscopic honeycombing with mucin stasis. CONCLUSION: The HRCT manifestations of NSIP are characteristic though not specific. In patients with consistent clinical features, the diagnosis of NSIP can be suspected by typical HRCT findings.

[Experimental study on treatment of pulmonary fibrosis by Chinese drugs and integrative Chinese and Western medicine].

OBJECTIVE: To compare the effects of treatment of pulmonary fibrosis (PF) by the Chinese herbal medicines, Radix Salviae miltiorrhizae (C1), Radix Astragalus membranaceus (C2) and Caulis Tripterygium wilfordii (C3); western drugs, hydrocortisone (W1) and azathioprine (W2), and combined W2 with C3. METHODS: Eighty SD rats were divided into 8 groups. Except the 10 rats in the normal control group, the other 70 rats were made into animal model of PF by bleomycin administration, and treated with various medicines, except the 10 rats in the model control group. The treatment started from the 15th day of modeling, the model animals were perfused with C1, C2, C3, W1, W2 and W2 + C3 respectively for 14 days. Rats were sacrificed by the end of experiment, their lung tissue was taken for pathological section to conduct the pathological examination under light microscope and computerized image quantitative analysis to evaluate the effects of the treatments objectively. RESULTS: The therapeutic effect of C1 was the best, that of W1 the second and C2 the third. W2 showed some effect, but PF worsened after the combined therapy of W2 and C3 was applied. CONCLUSION: Radix Salviae miltiorrhizae shows definite therapeutic effect in treating PF.