Surgical management of left heart endocarditis.

Between 1981 and 1987, 29 patients (20 men and 9 women, mean age 46 +/- 15) underwent a valvular replacement for endocarditis (19 aortic and 10 mitral). There were 25 native and 4 prosthetic valves. In 85% of cases, underlying valvular lesions were present. The oropharyngeal and the respiratory tracts were the most common sources of infection. In 81%, the infecting microorganism was gram-positive. In 21% of cases, a gram-negative was detected, always mixed with a gram-positive. One infection was caused by a Candida. Indications for surgery were severe valvular insufficiency or cardiac failure (90%), refractory sepsis (21%), thromboembolic events (11%). In 22%, multiple factors were present. A biologic valve was chosen in 12 cases (40%). Simultaneously with the valvular replacement, 4 ventricular septal perforations were occluded and 3 valvular annulus abscesses debrided. The operative mortality was 10% (3/29). The one-year survival is 96%. Two patients required reoperation at 6 months and 2 years, for partial dehiscence, with good subsequent evolution. The authors concluded that surgical operation is the most suitable treatment for unstable or complicated endocarditis, in case of cardiac failure, iterative thromboembolic events or refractory sepsis.

[Serum appearance kinetics of human menopausal gonadotropin (HMG) after intramuscular administration in women]. / Cinétique d'apparition sérique de la gonadotrophine ménopausique humaine (HMG) après administration intra-musculaire chez la femme.

Intramuscularly administered HMG in women induces an increase of serum FSH after 2 hours. Maximal values are reached between the 6 th and the 24 th hour and remain statistically increased until the 48 th hour. An important individual variability is however observed. The modifications of serum LH are inconstant.