Electrical production data of a domestic grid-connected rooftop PV plant in normal and shading faults conditions associated with solar and meteorological data in a tropical climate.

The proposed measured data combines PV plant electrical data with associated solar and meteorological data during normal and faulty conditions. Data are collected regarding a domestic rooftop PV plant of 4 kW, located in the La Réunion Island, in the South-West of Indian Ocean. The present dataset includes healthy behavior and different types of shading faults, identified and labelled by means of a numeric variable. The electrical data (voltage, current and power at AC and DC side as well as produced energy and grid frequency) are collected thanks to PV inverters. Global and diffuse irradiance, PV temperature and ambient temperature are acquired thanks to additional sensors. Electrical and meteorological data sampling frequencies are set to 0.2 Hz and 1 Hz respectively. At present, 12 months of data are available and the database is still being updated. The data streams from each connected device require proper techniques to ensure their persistence. To be able to provide both efficient ingestion and retrieval of these time series collections, the NoSQL database management system InfluxDB has been implemented. The whole dataset is available on Zenodo repository, and can be used, for instance, for PV modeling, PV plant behavior analysis, PV production forecasting and PV Fault Detection and Diagnosis (FDD) tool development.

PV System Failures Diagnosis Based on Multiscale Dispersion Entropy.

Photovoltaic (PV) system diagnosis is a growing research domain likewise solar energy's ongoing significant expansion. Indeed, efficient Fault Detection and Diagnosis (FDD) tools are crucial to guarantee reliability, avoid premature aging and improve the profitability of PV plants. In this paper, an on-line diagnosis method using the PV plant electrical output is presented. This entirely signal-based method combines variational mode decomposition (VMD) and multiscale dispersion entropy (MDE) for the purpose of detecting and isolating faults in a real grid-connected PV plant. The present method seeks a low-cost design, an ease of implementation and a low computation cost. Taking into account the innovation of applying these techniques to PV FDD, the VMD and MDE procedures as well as parameters identification are carefully detailed. The proposed FFD approach performance is assessed on a real rooftop PV plant with experimentally induced faults, and the first results reveal the MDE approach has good suitability for PV plants diagnosis.

Non-linearity of Metabolic Pathways Critically Influences the Choice of Machine Learning Model.

The use of machine learning (ML) in life sciences has gained wide interest over the past years, as it speeds up the development of high performing models. Important modeling tools in biology have proven their worth for pathway design, such as mechanistic models and metabolic networks, as they allow better understanding of mechanisms involved in the functioning of organisms. However, little has been done on the use of ML to model metabolic pathways, and the degree of non-linearity associated with them is not clear. Here, we report the construction of different metabolic pathways with several linear and non-linear ML models. Different types of data are used; they lead to the prediction of important biological data, such as pathway flux and final product concentration. A comparison reveals that the data features impact model performance and highlight the effectiveness of non-linear models (e.g., QRF: RMSE = 0.021 nmol·min-1 and R2 = 1 vs. Bayesian GLM: RMSE = 1.379 nmol·min-1 R2 = 0.823). It turns out that the greater the degree of non-linearity of the pathway, the better suited a non-linear model will be. Therefore, a decision-making support for pathway modeling is established. These findings generally support the hypothesis that non-linear aspects predominate within the metabolic pathways. This must be taken into account when devising possible applications of these pathways for the identification of biomarkers of diseases (e.g., infections, cancer, neurodegenerative diseases) or the optimization of industrial production processes.

Identification of flux checkpoints in a metabolic pathway through white-box, grey-box and black-box modeling approaches.

Metabolic pathway modeling plays an increasing role in drug design by allowing better understanding of the underlying regulation and controlling networks in the metabolism of living organisms. However, despite rapid progress in this area, pathway modeling can become a real nightmare for researchers, notably when few experimental data are available or when the pathway is highly complex. Here, three different approaches were developed to model the second part of glycolysis of E. histolytica as an application example, and have succeeded in predicting the final pathway flux: one including detailed kinetic information (white-box), another with an added adjustment term (grey-box) and the last one using an artificial neural network method (black-box). Afterwards, each model was used for metabolic control analysis and flux control coefficient determination. The first two enzymes of this pathway are identified as the key enzymes playing a role in flux control. This study revealed the significance of the three methods for building suitable models adjusted to the available data in the field of metabolic pathway modeling, and could be useful to biologists and modelers.

Flux prediction using artificial neural network (ANN) for the upper part of glycolysis.

The selection of optimal enzyme concentration in multienzyme cascade reactions for the highest product yield in practice is very expensive and time-consuming process. The modelling of biological pathways is a difficult process because of the complexity of the system. The mathematical modelling of the system using an analytical approach depends on the many parameters of enzymes which rely on tedious and expensive experiments. The artificial neural network (ANN) method has been successively applied in different fields of science to perform complex functions. In this study, ANN models were trained to predict the flux for the upper part of glycolysis as inferred by NADH consumption, using four enzyme concentrations i.e., phosphoglucoisomerase, phosphofructokinase, fructose-bisphosphate-aldolase, triose-phosphate-isomerase. Out of three ANN algorithms, the neuralnet package with two activation functions, "logistic" and "tanh" were implemented. The prediction of the flux was very efficient: RMSE and R2 were 0.847, 0.93 and 0.804, 0.94 respectively for logistic and tanh functions using a cross validation procedure. This study showed that a systemic approach such as ANN could be used for accurate prediction of the flux through the metabolic pathway. This could help to save a lot of time and costs, particularly from an industrial perspective. The R-code is available at: https://github.com/DSIMB/ANN-Glycolysis-Flux-Prediction.