A rare case of retained metallic foreign body in liver: case report and review of literature.

Introduction and importance: Foreign bodies in the liver are uncommon but can lead to severe conditions like liver abscess and sepsis. They typically enter through direct penetration, migration from the gastrointestinal tract, or through the blood. Common foreign objects include metal pins, or sewing needles swallowed accidentally. Case presentation: A 25-year-old male presented to our OPD with pain over the right abdomen with a prior history of projectile injury causing laceration over the right anterior abdomen with primary suturing. On radiological investigation, a retained foreign body was revealed. The metallic foreign body was embedded in the liver for 5 months. Removal of the foreign body was performed without any complications. Clinical discussion: Intrahepatic foreign bodies (FBs) in the liver can result from penetrating injuries, iatrogenic causes, or ingestion, particularly in children. Clinical presentations vary, and complications such as abscess formation may occur. Diagnosis involves imaging modalities like X-rays, ultrasonography, and computed tomography (CT) scans. The presented case highlights the importance of meticulous follow-up, as chronic pain manifested despite conservative management. The management of intrahepatic FBs depends on factors like size, location, and symptoms, with conservative approaches for stable patients. Surgical removal remains the mainstay of the treatment. Long-term monitoring is crucial to detect potential complications, and imaging studies play a key role in regular follow-up. Conclusion: Hepatic foreign bodies are rare, and symptoms vary based on size, type, and location, ranging from asymptomatic to complications such as abscess formation. Surgical removal is the main treatment, but in cases of noncomplicated hepatic foreign bodies, close follow-up is necessary.

Non-covalent interactions in molecular architectures and solvent-free catalytic activity towards CO2 fixation of mononuclear Co(III) complexes installed on modified Schiff base ligands.

A set of mononuclear cobalt(III) octahedral complexes {[Co(LH)(acac)] (Co-1H), [Co(LBr)(acac)] (Co-1Br), and [Co(LNO2)(acac)] (Co-1NO2)} were synthesized using new-generation N/O donors, maleonitrile-tethered, tetradentate heteroscorpionate half-reduced Schiff base ligands, 2-((E)-2-hydroxybenzylideneamino)-3-(pyridin-2-ylmethylamino)maleonitrile (H2LH), 2-((E)-(5-bromo-2-hydroxybenzylidene)amino)-3-((pyridin-2-ylmethyl)amino)maleonitrile (H2LBr), and 2-((E)-2-hydroxy-5-nitrobenzylideneamino)-3-(pyridin-2-ylmethylamino)maleonitrile (H2LNO2). All the compounds were well characterized spectroscopically and structurally. The non-covalent interactions present in the lattice of Co-complexes were studied in detail to explain the molecular architecture using the Hirshfeld surface (HS) analysis. The catalytic activity of CO2 fixation towards epoxides under mild and solvent-free conditions was demonstrated. The synthesized complexes are catalysts that are well-active towards the CO2 activation under ambient conditions, whereas most of the reported catalysts require harsh conditions.

A Rare Case of Primary Adenocarcinoma of the Gallbladder With Lymphoid Stroma.

Adenocarcinoma of the gallbladder is the most common gallbladder carcinoma. But lymphoid stroma in gallbladder carcinoma is one of the rarest presentations. A unique case of gallbladder adenocarcinoma with lymphoid stroma in a 47-year-old female is presented in this report. The surgically resected gallbladder demonstrated invasive adenocarcinoma with lymphoid stroma, though it was radiologically diagnosed as xanthogranulomatous cholecystitis. Adenocarcinoma was immunohistochemically positive for pancytokeratin (AE1/AE3), cytokeratin 7 (CK7), cytokeratin 20 (CK20), and carcinoembryonic antigen (CEA). Lymphoid stroma was positive for CD45, where B-cell zones were CD20 and CD79a positive, and T-cell zones were CD3 positive, with a larger T-cell subset being positive for CD4 than CD8. This is the fourth reported case of gallbladder adenocarcinoma with lymphoid stroma, which needs to be studied for pathogenesis, prognosis, and future therapy, if any.

Rigid N3O2-Pentadentate Ligand-Assisted Octacoordinate Mononuclear Ln(III) Complexes: Syntheses, Characterization, and Slow Magnetization Relaxation.

A series of air-stable mononuclear octacoordinate Ln(III) complexes, [(L)Ln(TPPO)3]OTf (Ln = Y (1·Y); Gd (1·Gd); Tb (1·Tb); Dy (1·Dy); Ho (1·Ho); and Er (1·Er)) and [(L)Ln(TPPO)(NO3)] (Ln = Y (2·Y) and Dy (2·Dy)), are synthesized employing a rigid N3O2-pentadentate chelating ligand as the basis ligand and meridional ancillary ligands (where H2L = 2,6-diacetylpyridine bis-benzoylhydrazone, TPPO = triphenylphosphine oxide, and OTf- = trifluoromethanesulfonate). All the complexes are synthesized under aerobic conditions and characterized comprehensively by spectroscopic and X-ray crystallographic techniques. Magnetic property investigation on the polycrystalline solid samples of 1·Ln (Ln = Gd, Tb, Dy, Ho, and Er) and 2·Dy are reported. A field-induced single-molecule magnet behavior was observed for the Dy derivatives. 1·Dy exhibits the highest effective energy barrier of magnetization reversal, U eff/k B = 47 K under H dc = 1 kOe among the complexes presented herein.

The effectiveness of contact tracing in mitigating COVID-19 outbreak: A model-based analysis in the context of India.

The ongoing pandemic situation due to COVID-19 originated from the Wuhan city, China affects the world in an unprecedented scale. Unavailability of totally effective vaccination and proper treatment regimen forces to employ a non-pharmaceutical way of disease mitigation. The world is in desperate demand of useful control intervention to combat the deadly virus. This manuscript introduces a new mathematical model that addresses two different diagnosis efforts and isolation of confirmed cases. The basic reproductive number, R 0 , is inspected, and the model's dynamical characteristics are also studied. We found that with the condition R 0 < 1 , the disease can be eliminated from the system. Further, we fit our proposed model system with cumulative confirmed cases of six Indian states, namely, Maharashtra, Tamil Nadu, Andhra Pradesh, Karnataka, Delhi and West Bengal. Sensitivity analysis carried out to scale the impact of different parameters in determining the size of the epidemic threshold of R 0 . It reveals that unidentified symptomatic cases result in an underestimation of R 0 whereas, diagnosis based on new contact made by confirmed cases can gradually reduce the size of R 0 and hence helps to mitigate the ongoing disease. An optimal control problem is framed using a control variable u ( t ) , projecting the effectiveness of diagnosis based on traced contacts made by a confirmed COVID patient. It is noticed that optimal contact tracing effort reduces R 0 effectively over time.

Enantio- and regioselective asymmetric allylic substitution using a chiral aminophosphinite ruthenium complex: an experimental and theoretical investigation.

The design and synthesis of a new chiral aminophosphinite-ligated ruthenium complex is described. The ruthenium complex, [Ru(AMP)2(CH3CN)2][BPh4]2 {AMP = (S)-tert-butyl 1-(diphenylphosphinooxy)-3-methylbutan-2-ylcarbamate}, has been found to catalyze nucleophilic addition of phenol and carboxylic acid to allyl chloride in a highly regioselective fashion with enantiomeric excess ranging from 12 to 90.

Controlling the regioselectivity of the ring opening of spiro-epoxyoxindoles for efficient synthesis of C(3)-N(1')-bisindoles and C(3)-N(1')-diindolylmethane.

An efficient strategy for the construction of both C(3)-N(1') bisindoles and C(3)-N(1') diindolylmethane has been explored via proper tuning of the nucleophilicity of indoline/indole to spiro-epoxyoxindole. Lewis acid-catalyzed highly regio- as well as chemoselective coupling at the C-3 centre of spiro-epoxyoxindoles with indolines furnishes C(3)-N(1') bisindoles whereas base mediated and Lewis acid-catalyzed regioselective coupling at the less hindered site of spiro-epoyoxindoles with indoles via the SN2 mechanism provides C(3)-N(1') diindolylmethane.

Catalyst-Free "On-Water" Regio- and Stereospecific Ring-Opening of Spiroaziridine Oxindole: Enantiopure Synthesis of Unsymmetrical 3,3'-Bisindoles.

A catalyst-free water-mediated regio- and stereospecific ring-opening reaction of nonracemic spiroaziridine oxindoles and indoles has been developed with retention of configuration. This method provides direct access to enantiopure 3,3'-mixed bisindoles with excellent yield and enantioselectivity (up to 98% ee).

Synthesis of Chiral Spiro-Aziridine Oxindoles via Aza-Corey-Chaykovsky Reaction of Isatin Derived N-tert-Butanesulfinyl Ketimines.

A general and direct strategy for the synthesis of chiral spiro-aziridine oxindoles has been developed via an aza-Corey-Chaykovsky reaction of isatin-derived N-tert-butanesulfinyl ketimines with excellent selectivity (dr = 98:2 to >99:1). The method is explored for the synthesis of chiral 3-substituted spiro-aziridine oxindoles with high (2S,3S)-selectivity over (2S,3R).