Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Más filtros











Base de datos
Intervalo de año de publicación
2.
Calcif Tissue Int ; 80(2): 103-10, 2007 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-17308992

RESUMEN

Most previous studies to identify loci involved in bone mineral density (BMD) regulation have used inbred strains with high and low BMD in generating F(2) mice. However, differences in BMD may not be a requirement in selecting parental strains for BMD quantitative trait loci (QTL) studies. In this study, we intended to identify novel QTL using a cross of two strains, MRL/MpJ (MRL) and CAST/EiJ (CAST), both of which exhibit relatively high BMD when compared to previously used strains. In addition, CAST was genetically distinct. We generated 328 MRL x CAST F(2) mice of both sexes and measured femur BMD and periosteal circumference (PC) using peripheral quantitative computed tomography. Whole-genome genotyping was performed with 86 microsatellite markers. A new BMD QTL on chromosome 10 and another suggestive one on chromosome 15 were identified. A significant femur PC QTL identified on chromosome 9 and a suggestive one on chromosome 2 were similar to those detected in MRL x SJL. QTL were also identified for other femur and forearm bone density and bone size phenotypes, some of which were colocalized within the same chromosomal positions as those for femur BMD and femur PC. This study demonstrates the utility of crosses involving inbred strains of mice which exhibit a similar phenotype in QTL identification.


Asunto(s)
Densidad Ósea/genética , Huesos/anatomía & histología , Cruzamientos Genéticos , Sitios de Carácter Cuantitativo , Animales , Mapeo Cromosómico , Cromosomas de los Mamíferos , Femenino , Fémur/anatomía & histología , Escala de Lod , Masculino , Ratones , Ratones Endogámicos , Tamaño de los Órganos
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA