A generative adversarial model of intrusive imagery in the human brain.

The mechanisms underlying the subjective experiences of mental disorders remain poorly understood. This is partly due to long-standing over-emphasis on behavioral and physiological symptoms and a de-emphasis of the patient's subjective experiences when searching for treatments. Here, we provide a new perspective on the subjective experience of mental disorders based on findings in neuroscience and artificial intelligence (AI). Specifically, we propose the subjective experience that occurs in visual imagination depends on mechanisms similar to generative adversarial networks that have recently been developed in AI. The basic idea is that a generator network fabricates a prediction of the world, and a discriminator network determines whether it is likely real or not. Given that similar adversarial interactions occur in the two major visual pathways of perception in people, we explored whether we could leverage this AI-inspired approach to better understand the intrusive imagery experiences of patients suffering from mental illnesses such as post-traumatic stress disorder (PTSD) and acute stress disorder. In our model, a nonconscious visual pathway generates predictions of the environment that influence the parallel but interacting conscious pathway. We propose that in some patients, an imbalance in these adversarial interactions leads to an overrepresentation of disturbing content relative to current reality, and results in debilitating flashbacks. By situating the subjective experience of intrusive visual imagery in the adversarial interaction of these visual pathways, we propose testable hypotheses on novel mechanisms and clinical applications for controlling and possibly preventing symptoms resulting from intrusive imagery.

Memories with a blind mind: Remembering the past and imagining the future with aphantasia.

Our capacity to re-experience the past and simulate the future is thought to depend heavily on visual imagery, which allows us to construct complex sensory representations in the absence of sensory stimulation. There are large individual differences in visual imagery ability, but their impact on autobiographical memory and future prospection remains poorly understood. Research in this field assumes the normative use of visual imagery as a cognitive tool to simulate the past and future, however some individuals lack the ability to visualise altogether (a condition termed "aphantasia"). Aphantasia represents a rare and naturally occurring knock-out model for examining the role of visual imagery in episodic memory recall. Here, we assessed individuals with aphantasia on an adapted form of the Autobiographical Interview, a behavioural measure of the specificity and richness of episodic details underpinning the memory of events. Aphantasic participants generated significantly fewer episodic details than controls for both past and future events. This effect was most pronounced for novel future events, driven by selective reductions in visual detail retrieval, accompanied by comparatively reduced ratings of the phenomenological richness of simulated events, and paralleled by quantitative linguistic markers of reduced perceptual language use in aphantasic participants compared to those with visual imagery. Our findings represent the first systematic evidence (using combined objective and subjective data streams) that aphantasia is associated with a diminished ability to re-experience the past and simulate the future, indicating that visual imagery is an important cognitive tool for the dynamic retrieval and recombination of episodic details during mental simulation.

A cognitive profile of multi-sensory imagery, memory and dreaming in aphantasia.

For most people, visual imagery is an innate feature of many of our internal experiences, and appears to play a critical role in supporting core cognitive processes. Some individuals, however, lack the ability to voluntarily generate visual imagery altogether - a condition termed "aphantasia". Recent research suggests that aphantasia is a condition defined by the absence of visual imagery, rather than a lack of metacognitive awareness of internal visual imagery. Here we further illustrate a cognitive "fingerprint" of aphantasia, demonstrating that compared to control participants with imagery ability, aphantasic individuals report decreased imagery in other sensory domains, although not all report a complete lack of multi-sensory imagery. They also report less vivid and phenomenologically rich autobiographical memories and imagined future scenarios, suggesting a constructive role for visual imagery in representing episodic events. Interestingly, aphantasic individuals report fewer and qualitatively impoverished dreams compared to controls. However, spatial abilities appear unaffected, and aphantasic individuals do not appear to be considerably protected against all forms of trauma symptomatology in response to stressful life events. Collectively, these data suggest that imagery may be a normative representational tool for wider cognitive processes, highlighting the large inter-individual variability that characterises our internal mental representations.

The role of masculinity in men's help-seeking for depression: A systematic review.

AIM: Conformity to traditional masculine gender norms may deter men's help-seeking and/or impact the services men engage. Despite proliferating research, current evidence has not been evaluated systematically. This review summarises findings related to the role of masculinity on men's help-seeking for depression. METHOD: Six electronic databases were searched using terms related to masculinity, depression and help-seeking. Titles and abstracts were reviewed and data systematically extracted and examined for methodological quality. RESULTS: Of 1927 citations identified, 37 met inclusion criteria. Seventeen (46%) studies reported qualitative research; eighteen (49%) employed quantitative methods, and two (5%) mixed methods. Findings suggest conformity to traditional masculine norms has a threefold effect on men experiencing depression, impacting: i) their symptoms and expression of symptoms; ii) their attitudes to, intention, and, actual help-seeking behaviour; and, iii) their symptom management. CONCLUSION: Results demonstrate the problematic impact of conformity to traditional masculine norms on the way men experience and seek help for depression. Tailoring and targeting clinical interventions may increase men's service uptake and the efficacy of treatments. Future research examining factors associated with men's access to, and engagement with depression care will be critical to increasing help-seeking, treatment uptake, and effectual self-management among men experiencing depression.