Asunto(s)
Erupciones por Medicamentos/etiología , Piperidinas/efectos adversos , Pirimidinas/efectos adversos , Pirroles/efectos adversos , Urticaria/inducido químicamente , Alopecia/tratamiento farmacológico , Humanos , Masculino , Piperidinas/administración & dosificación , Inhibidores de Proteínas Quinasas/administración & dosificación , Inhibidores de Proteínas Quinasas/efectos adversos , Pirimidinas/administración & dosificación , Pirroles/administración & dosificación , Adulto JovenRESUMEN
Lichen planus (LP) is an incompletely understood T-cell mediated auto-immune dermatosis. When LP involves the genitalia it may present as painful, pruritic erosions that can be exquisitely tender, causing distress and genitourinary and sexual dysfunction. Management of erosive genital LP is often suboptimal. Despite higher order evidence demonstrating the efficacy of oral acitretin in the management of cutaneous and oral LP, it still features below other immunosuppressive and immunomodulatory therapies in many clinicians' therapeutic ladder. We present a case of severe erosive penile LP, successfully treated with oral acitretin after topical and oral corticosteroids failed to induce remission.
Asunto(s)
Acitretina/uso terapéutico , Queratolíticos/uso terapéutico , Liquen Plano/tratamiento farmacológico , Enfermedades del Pene/tratamiento farmacológico , Humanos , Masculino , Adulto JovenRESUMEN
Acute generalised exanthematous pustulosis (AGEP) or toxic pustuloderma (TP) is an uncommon though well-recognised cutaneous hypersensitivity reaction that is usually drug-induced. It presents with a triad of scattered sterile pustules, fever and malaise. Acute localised exanthematous pustulosis (ALEP) is a rare and unusual variant of AGEP. We describe a case of ALEP triggered by oral clindamycin that occurred during pregnancy.
