1.
J Infect Dis
; 224(10): 1690-1693, 2021 11 22.
Artículo
en Inglés
| MEDLINE
| ID: mdl-34514509
RESUMEN
Short-term humoral and cellular immune responses are diminished after BNT162b2 messenger ribonucleic acid coronavirus disease 2019 (COVID-19) vaccination in COVID-19-naive nursing home residents, a population particularly vulnerable to the disease. We found both responses to decline after 4 weeks and remain lower than those of healthcare workers after 24 weeks, with an estimated half-life of the antibody response of 47 days. At 4 weeks, older age was significantly associated with a decreased humoral response, and diabetes mellitus and active malignancy were associated with a decreased cellular response. Our results imply that COVID-19-naive nursing home residents are a target group for booster vaccination trials.
Asunto(s)
COVID-19 , Inmunidad Humoral , Anticuerpos Antivirales , Vacuna BNT162 , COVID-19/prevención & control , Humanos , Casas de Salud , ARN , Vacunación
2.
Clin Infect Dis
; 73(11): 2145-2147, 2021 12 06.
Artículo
en Inglés
| MEDLINE
| ID: mdl-33825869