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1.
Nutrients ; 11(5)2019 May 22.
Artículo en Inglés | MEDLINE | ID: mdl-31121859

RESUMEN

BACKGROUND: Holder pasteurization (HoP) is the recommended method of pasteurization for donor human milk (DHM). The aim of the present study was to compare nutritional and microbiological impact on DHM of a new technique of pasteurization based on technical changes of HoP. METHODS: We analyzed milk samples from 25 donors. Each sample, derived from one breast milk expression, was subdivided into three aliquots according to pasteurization: The first was not pasteurized, the second pasteurized by HoP, and the third was pasteurized by modified HoP (MHoP). Each aliquot was assessed as to its microbiological and nutritional profile. Nutritional profile included calcium and triglycerides concentrations detected by spectrophotometry and amino acid levels assessed by high-performance liquid chromatography (HPLC). RESULTS: Triglycerides were significantly lower in pasteurized, by both methods, than in not pasteurized aliquots, while calcium and amino acids concentration were similar. Microbiological profile did not differ between HoP and MHoP aliquots. CONCLUSIONS: HoP and MHoP seem to have similar efficacy in preserving some nutritional characteristics of DHM and to confer similar microbiological safety. MHoP is time-saving and potentially costs-effective when compared to HoP, and it is; therefore, potentially of more interest from a practical point of view. Further studies are needed to confirm these findings.


Asunto(s)
Leche Humana/química , Leche Humana/microbiología , Valor Nutritivo , Pasteurización/métodos , Donantes de Tejidos , Aminoácidos/análisis , Calcio/análisis , Femenino , Humanos , Bancos de Leche Humana , Datos Preliminares , Triglicéridos/análisis
2.
Clin Chem Lab Med ; 52(11): 1569-77, 2014 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-24897399

RESUMEN

BACKGROUND: Point-of-care testing (POCT) is a successful methodology for meeting clinical expectations of rapid and accurate results. Scientific literature has moreover highlighted and confirmed the necessity of individuating the best technological solution, in accordance with clinical requirements and contextualized to the whole health organization, where it will be implemented. Health Technology Assessment (HTA) can assist in reaching an appropriate and contextualized decision on a health technology. The aim of this study is to adapt a HTA core model for improving the evaluation of a POCT technology: blood gas analyzers. METHODS: The European Network for Health Technology Assessment (EUnetHTA) core model for diagnostic technologies was applied for evaluating globally marketed blood gas analyzers. Evaluation elements were defined according to available literature and validated using the Delphi method. RESULTS: A HTA model of 71 issues, subdivided into 26 topics and 10 domains, was obtained by interviewing 11 healthcare experts over two rounds of Delphi questionnaires. Ten context parameters were identified in order to define the initial scenario from which the technology assessment was to begin. CONCLUSIONS: The model presented offers a systematic and objective structure for the evaluation of blood gas analyzers, which may play a guidance role for healthcare operators approaching the evaluation of such technologies thus improving, in a contextualized fashion, the appropriateness of purchasing.


Asunto(s)
Análisis de los Gases de la Sangre/métodos , Gases/sangre , Modelos Teóricos , Evaluación de la Tecnología Biomédica , Análisis de los Gases de la Sangre/instrumentación , Técnica Delphi , Europa (Continente) , Humanos , Cooperación Internacional , Entrevistas como Asunto , Sistemas de Atención de Punto , Encuestas y Cuestionarios
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