1.
Antimicrob Agents Chemother
; 45(6): 1886-8, 2001 Jun.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11353644
RESUMEN
The antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates (mean 50% inhibitory concentration of 43 nmol/liter) of Plasmodium falciparum. There was no correlation between the responses to DU-1102 and chloroquine and only a low correlation between the responses to DU-1102 and pyrimethamine, suggesting an independent mode of action of the trioxaquine against the parasites.
Asunto(s)
Aminoquinolinas/farmacología , Antimaláricos/farmacología , Compuestos Bicíclicos Heterocíclicos con Puentes/farmacología , Plasmodium falciparum/efectos de los fármacos , Animales , Cloroquina/farmacología , Pirimetamina/farmacología , Análisis de Regresión
2.
Chembiochem
; 1(4): 281-3, 2000 Nov 17.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11828420