RESUMEN
In recent years there has been a great improvement in molecular characterization of acute myeloid leukemia (AML) allowing the stratification of patients in different rate of risk. Patients with FLT3 mutated AML have poor prognosis because of resistance to induction chemotherapy or early relapse. Several first and second generation molecules, able to inhibit FLT3 signaling have been developed and many single agent or combination studies are ongoing. Of these, quizartinib seems to have the best clinical activity. Unfortunately, resistance to FLT3 inhibitors has been observed and many scientists are currently investigating new strategy to restore sensitivity to FLT3 inhibitors.
Asunto(s)
Antineoplásicos/farmacología , Leucemia Mieloide Aguda/tratamiento farmacológico , Inhibidores de Proteínas Quinasas/farmacología , Tirosina Quinasa 3 Similar a fms/antagonistas & inhibidores , Antineoplásicos/química , Humanos , Leucemia Mieloide Aguda/metabolismo , Estructura Molecular , Inhibidores de Proteínas Quinasas/química , Tirosina Quinasa 3 Similar a fms/genética , Tirosina Quinasa 3 Similar a fms/metabolismoRESUMEN
T-cell Acute Lymphoblastic Leukemia (T-cell ALL) is a rare haematological neoplasia, that affects children and less commonly adults. Female genital tract and particularly uterus involvement in acute ALL is rare. This report presents the CT features of a 64-year-old woman with uterine relapse of T-cell ALL, occurring 11 months after the diagnosis, as a second, unique relapse of disease. The patient was asymptomatic when a CT examination showed a homogenous thickness of the uterine wall in comparison with the previous CT examination. Histology from biopsy specimens, obtained through hysteroscopy, confirmed T-cell ALL localisation (TdT+, CD10+, CD3c+ and CD2+). The uterus could be a site of relapse in patients suffering from ALL. Even though an MRI examination could better demonstrate the disease in cases of suspected female genital tract involvement by ALL, the comparison of differences between a present and a previous CT examination is sufficient to suspect the diagnosis.
Asunto(s)
Infiltración Leucémica/diagnóstico por imagen , Leucemia-Linfoma Linfoblástico de Células T Precursoras/diagnóstico por imagen , Tomografía Computarizada por Rayos X , Útero/diagnóstico por imagen , Antígenos de Diferenciación de Linfocitos T/análisis , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Biopsia , Neoplasias de la Mama/tratamiento farmacológico , ADN Nucleotidilexotransferasa/análisis , Femenino , Humanos , Histeroscopía , Inmunofenotipificación , Persona de Mediana Edad , Neoplasias Primarias Secundarias , Leucemia-Linfoma Linfoblástico de Células T Precursoras/tratamiento farmacológico , Leucemia-Linfoma Linfoblástico de Células T Precursoras/patología , Linfocitos T/química , Linfocitos T/patologíaAsunto(s)
Antineoplásicos/uso terapéutico , Leucemia Mielógena Crónica BCR-ABL Positiva/tratamiento farmacológico , Recurrencia Local de Neoplasia/diagnóstico , Piperazinas/uso terapéutico , Pirimidinas/uso terapéutico , Benzamidas , Humanos , Mesilato de Imatinib , Leucemia Mielógena Crónica BCR-ABL Positiva/genética , Leucemia Mielógena Crónica BCR-ABL Positiva/patología , Masculino , Persona de Mediana Edad , Proteínas Tirosina Quinasas/antagonistas & inhibidores , Factores de Tiempo , Resultado del TratamientoAsunto(s)
Leucemia Mielógena Crónica BCR-ABL Positiva/patología , Piperazinas/uso terapéutico , Pirimidinas/uso terapéutico , Adulto , Anciano , Benzamidas , Médula Ósea/patología , Recuento de Células , Femenino , Humanos , Mesilato de Imatinib , Leucemia Mielógena Crónica BCR-ABL Positiva/tratamiento farmacológico , Masculino , Persona de Mediana Edad , Inducción de RemisiónRESUMEN
The present study examined the effects of a highly preferred, biologically relevant olfactory stimulus (i.e., home-nest odors) on the startle response in preweanling rats. Although the rats detected the odor (as revealed by reductions in ultrasound vocalizations) it had no effect on either the initial magnitude of the startle response or habituation of this response across 80 test trials. These results are discussed in relation to recent studies on modulation of the startle response in developing rats, the effects of olfactory stimuli on the startle response, and the pleasure-attenuation of startle in nonhuman subjects.
