Intra-operative electron beam radiotherapy for newly dignosed and recurrent malignant gliomas: feasibility and lon-term outcomes

INTRODUCTION: Intra-operative electron beam radiotherapy (IOERT) is an alternative to dose escalation for the treatment of central nervous system tumors. The objective of this study was to describe the feasibility and long-term outcomes of IOERT in the treatment of primary and recurrent gliomas. MATERIALS AND METHODS: From January 1992 through December 2002, all patients treated with IOERT at the Hospital San Francisco de Asis, Madrid/Spain were retrospectively reviewed. The selection criteria included patients with superficial tumors, KPS >70 % and lesions <6 cm. Irradiation was administered in one section. The prescribed dose considered the amount of post-resection residual tumor, previous radiotherapy and the tolerance level of brain structures exposed to IOERT. RESULTS: There were 17 patients (53 %) with newly diagnosed malignant brain gliomas and 15 patients with recurrent tumors. The delivered dose varied from 8 to 20 Gy (median 12.5 Gy) for primary and from 8 to 16 Gy (median 10 Gy) for recurrent tumors. The median overall survival for the entire cohort was 13 months (14 and 10.4 months for the primary and recurrent, respectively). Three patients presented with radionecrosis, one patient with osteomyelitis at the craniotomy bone flap, one with intracerebral hemorrhage, and another patient experienced a pulmonary embolism. CONCLUSIONS: IOERT is a feasible technique and can be viewed as a tool in the treatment of newly diagnosed or recurrent brain gliomas (AU)

Quistes del rafe medio escrotal / Median raphe cyst of the scrotum

Los quistes del rafe medio escrotal son lesiones producidas por un defecto de cierre del rafe durante la embriogénesis. A pesar de tratarse de alteraciones congénitas, su curso silente determina su diagnóstico infrecuente durante la infancia y, por tanto, su desconocimiento por gran parte de los pediatras que, en ocasiones, los confunden con otras lesiones de origen quístico, tumoral o infeccioso. Debido a su naturaleza benigna y su carácter silente, no precisan ningún tratamiento. En los casos en que produzcan sintomatología, generalmente desencadenada por traumatismos o infecciones, es recomendable la exéresis quirúrgica de los quistes. Con el objetivo de facilitar el diagnóstico y el manejo de dichas lesiones, presentamos el caso de un varón que a los 8 meses de vida presentaba tres lesiones en el rafe medio escrotal, compatibles con quistes del rafe medio, uno de los cuales se complicó 5 años más tarde con la formación de un absceso(AU)

The scrotal median raphe cysts are injuries produced because of a default in the process of fusion of the raphe during embryogenesis. Despite of being congenital anomalies, its silent progress makes its diagnosis infrequent during childhood and, therefore, the ignorance of a lot of pediatricians who sometimes mistake these anomalies with others cystic, tumor or infectious damages. Because of its benign nature and that they are usually asymptomatic, it isn’t necessary any treatment. In symptomatic cases, usually produced because of trauma or infection, it is advisable to remove the cysts. In order to facilitate the diagnosis and management of these lesions, we present the case of an 8 months old male who had three injuries in median raphe of the scrotum consistent with median raphe cysts, one of which complicated five years later with the formation of an abscess(AU)

Tromboembolismo pulmonar masivo: una rara causa de prolongación del QT / Massive pulmonary thromboembolism: a rare case of QT prolongation

No disponible

Salmonella Tyfhi como agente excepcional de pericarditis infecciosa: a propósito de un caso / Salmonella Typhi as an excepcional agent in infectious pericarditis

Presentamos , dado la infrecuente del caso, un cuadro de pericarditis infecciosa producida por S. typhi en un paciente pluripatológico, confirmado por la clínica, exploración, pruebas complementarias y estudio microbiológico, que fueron compatibles con dicha entidad. Una lesión pericárdica o la presencia de un pequeño derrame pericardio aséptico previo, podría haber servido de excelente caldo de cultivo para este microorganismo, en este caso favorecido por la comorbilidad asociada. El drenaje pericardio y el tratamiento antibiótico parenteral llevado a cabo, es la mejor medida terapéutica, siendo innecesaria el recurso del tratamiento intrapericárdico (AU)

Given the infrequency of the case, we present a medical profile of infectious pericarditis due to S. typhi in a patient with several pathologies, confirmed by clinical examination, complementary tests and microbiological study compatible with said entity. Pericardial injury, or the presence of a small previous aseptic pericardial effusion, may have been useful as an excellent culture medium for this microorganism, helped in this case by associated comorbididity. Pericardial drainage and parenteral antibiotic treatment carried out are the best therapeutic measures being unnecessary resorting to intrapericardial treatment (AU)

Personalidad y uso-abuso de cocaína / No disponible

Objetivos: determinar los rasgos de personalidad asociados al consumo de cocaína. Método: 3634 reclutas y 2841estudiantes de secundaria cumplimentaron el EPQ-A y la Escala de Búsqueda de Sensaciones. Cada muestra fue dividida en 3 grupos; G1: no consumidores de sustancias ilegales, G2: consumidores de sustancias ilegales diferentes de la cocaína, G3: consumidores de cocaína más otras sustancias legales e ilegales. Resultados: Neuroticismo: reclutas y estudiantes mujeres: G2 y G3 puntuaron significativamente más alto que el otro grupo; estudiantes varones: sin diferencias entre grupos. Intro-extroversión: reclutas: G2 obtuvo puntuaciones significativamente más elevadas; estudiantes varones y mujeres: G1 puntuó significativamente más bajo que los otros dos grupos. Psicoticismo: en las tres muestras diferencias significativas entre los 3 grupos, G3 obtuvo las puntuaciones más altas. Búsqueda de sensaciones: las tres muestras obtienen los mismos resultados que en psicoticismo. Conclusiones: existen diferencias de personalidad en función del consumo de cocaína (AU)

Objective: to determine the personality traits associated with cocaine consumption. Methods: 3634 military recruits and 2841 secondary school students completed the EPQ-A and the Sensation Seeking Scale. Each sample was divided into three groups: G1: non consumption of illegal substances; G2: consumption of illegal substances different from cocaine; G3: consumption of cocaine plus other legal and illegal substances. Results: Neuroticism: recruits and female students: G2 and G3 scored significantly higher than the other group; male students: no significant differences among groups. Introextroversion: recruits: G2 scored significantly higher than the other two groups; male and female students: G1 scored significantly lower. Psychoticism: in all samples significant differences were found among the three groups, G3 obtained the highest score. Sensation seeking: the three samples obtained the same results as those obtained in pscyhoticism. Conclusions: consumption of cocaine is associated with specific personality traits (AU)