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1.
BMC Pediatr ; 24(1): 82, 2024 Jan 26.
Artículo en Inglés | MEDLINE | ID: mdl-38279097

RESUMEN

BACKGROUND: Severe neonatal hyperbilirubinemia could lead to kernicterus and neonatal death. This study aimed to analyze the association between single nucleotide polymorphisms in genes involved in bilirubin metabolism and the incidence of severe hyperbilirubinemia. METHODS: A total of 144 neonates with severe hyperbilirubinemia and 50 neonates without or mild hyperbilirubinemia were enrolled in 3 institutions between 2019 and 2020. Twelve polymorphisms of 5 genes (UGT1A1, SLCO1B1, SLCO1B3, BLVRA, and HMOX1) were analyzed by PCR amplification of genomic DNA. Genotyping was performed using an improved multiplex ligation detection reaction technique based on ligase detection reaction. RESULTS: The frequencies of the A allele in UGT1A1-rs4148323 and the C allele in SLCO1B3-rs2417940 in the severe hyperbilirubinemia group (30.2% and 90.6%, respectively) were significantly higher than those in the controls (30.2% vs.13.0%, 90.6% vs. 78.0%, respectively, both p < 0.05). Haplotype analysis showed the ACG haplotype of UGT1A1 were associated with an increased hyperbilirubinemia risk (OR 3.122, p = 0.001), whereas the GCG haplotype was related to a reduced risk (OR 0.523, p = 0.018). CONCLUSION: The frequencies of the A allele in rs4148323 and the C allele in rs2417940 are highly associated with the incidence of severe hyperbilirubinemia in Chinese Han neonates. TRIAL REGISTRATION: Trial registration number:ChiCTR1800020424; Date of registration:2018-12-29.


Asunto(s)
Hiperbilirrubinemia Neonatal , Polimorfismo de Nucleótido Simple , Recién Nacido , Humanos , Transportador 1 de Anión Orgánico Específico del Hígado/genética , Alelos , Hiperbilirrubinemia Neonatal/genética , Glucuronosiltransferasa/genética , China/epidemiología , Miembro 1B3 de la Familia de los Transportadores de Solutos de Aniones Orgánicos/genética , Hemo-Oxigenasa 1/genética , Hemo-Oxigenasa 1/metabolismo
2.
Zhongguo Dang Dai Er Ke Za Zhi ; 25(7): 672-677, 2023 Jul 15.
Artículo en Chino | MEDLINE | ID: mdl-37529947

RESUMEN

In December 2022, the American Academy of Pediatrics released a clinical guideline for point-of-care ultrasonography (POCUS) in the neonatal intensive care unit (NICU). The guideline outlined the development and current status of POCUS in the NICU, and summarized the key elements and implementation guidelines for successful implementation of POCUS in the NICU. This article provides an overview of the key points of the clinical guideline and analyzes the current status of POCUS in China, providing a reference for the implementation of POCUS in neonatal care in China.


Asunto(s)
Unidades de Cuidado Intensivo Neonatal , Sistemas de Atención de Punto , Recién Nacido , Humanos , Estados Unidos , Niño , Ultrasonografía , China
3.
Pediatr Int ; 65(1): e15476, 2023 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-36651813

RESUMEN

BACKGROUND: Fever is a common symptom in children with infectious mononucleosis (IM). However, the significance of the duration of a fever is poorly understood. This study aimed to analyze the risk factors for persistent fever in children with IM. METHODS: Patients diagnosed with IM (aged <18 years; except those with concomitant hematological malignancies or tumor diseases) in a high-volume academic hospital in 2019 were reviewed from a prospectively maintained database. Children with transient fever (≤7 days) were compared with those with persistent fever (>7 days). The risk factors for persistent fever in children with IM were examined using binary logistic regression. Furthermore, the predictive ability of these risk factors was assessed and presented using a receiver operating characteristic (ROC) curve. RESULTS: Of the 184 children included in this study, 131 (71.96%) belonged to the transient fever group and 53 (28.04%) belonged to the persistent fever group (median age: 49 and 64 months, respectively; p = 0.093). Statistical significance was observed in hepatomegaly, alanine aminotransferase level, blood triglyceride level, and blood Epstein-Barr virus polymerase chain reaction (EBV-PCR) copy number (all p < 0.05). Binary logistic regression revealed that high blood triglyceride level was the risk factor for persistent fever in children with IM. High blood triglyceride level predicted persistent fever duration with an area under the ROC curve of 0.73 and an optimal cutoff value of 1.315 mmol/L. CONCLUSION: High blood triglyceride level was the risk factor for persistent fever in children with IM. Thus, children with elevated levels of blood triglycerides need additional care. To diagnose IM, a blood EBV-PCR is more useful than a throat-swab EBV-PCR.


Asunto(s)
Infecciones por Virus de Epstein-Barr , Mononucleosis Infecciosa , Niño , Humanos , Preescolar , Mononucleosis Infecciosa/complicaciones , Mononucleosis Infecciosa/diagnóstico , Mononucleosis Infecciosa/epidemiología , Infecciones por Virus de Epstein-Barr/complicaciones , Infecciones por Virus de Epstein-Barr/diagnóstico , Infecciones por Virus de Epstein-Barr/epidemiología , Herpesvirus Humano 4 , Factores de Riesgo , Fiebre/etiología
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