RESUMEN
A new isoflavanone compound, ficustikounone A (1), together with 22 known flavones, was isolated from Ficus tikoua Bur. The structures of these isolates were determined by UV, ECD, HRESIMS, 1D and 2D spectral analyses.
Asunto(s)
Ficus/química , Isoflavonas/aislamiento & purificación , Células A549 , Línea Celular Tumoral , Flavonas , Células Hep G2 , Humanos , Isoflavonas/química , Estructura Molecular , Fitoquímicos/química , Fitoquímicos/aislamiento & purificación , Plantas Medicinales/químicaRESUMEN
The aerial parts of Epilobium plants are widely used as folk medicine and food around the world. The present study was aimed to investigate the antioxidant activities and active chemical constituents from Epilobium angustifolium L. The results revealed that the EtOAc extract, rich in phenolic compounds and flavonoids (16.81 ± 0.67 g GAE/100 g extract and 4.95 ± 0.21 g QE/100 g extract, respectively), possessed significantly antioxidant activities in reducing power, DPPH radical scavenging activity, ABTS radical scavenging activity and highly in inhibiting lipid peroxidation activity. Simultaneously, active fractions F to H from EtOAc extracts showing potent in vitro antioxidant activities also contained high content of total phenolic and flavonoid. Twenty-eight compounds were identified as phenolic compounds and flavonoids by LC-MS/MS. The results illustrate that the E. angustifolium L., which is rich in phenolics, could be used as a natural resource of antioxidant ingredient.
Asunto(s)
Antioxidantes/farmacología , Epilobium/química , Fenoles/análisis , Extractos Vegetales/farmacología , Antioxidantes/química , Cromatografía Líquida de Alta Presión/métodos , Flavonoides/análisis , Flavonoides/química , Depuradores de Radicales Libres/química , Depuradores de Radicales Libres/farmacología , Peroxidación de Lípido/efectos de los fármacos , Fenoles/química , Componentes Aéreos de las Plantas/química , Extractos Vegetales/análisis , Extractos Vegetales/química , Espectrometría de Masa por Ionización de Electrospray/métodos , Espectrometría de Masas en Tándem , Sustancias Reactivas al Ácido Tiobarbitúrico/metabolismoRESUMEN
Phytochemical investigation on the stems of Kadsura renchangiana led to the isolation of two new sesquiterpenoids, renchangianins F and G (1 and 2). Their structures were elucidated by spectroscopic methods, including 2D NMR techniques. The in vitro cytotoxic activities of the isolates were studied against HepG2, A549, and LN229 cancer cell lines.
Asunto(s)
Antineoplásicos Fitogénicos/aislamiento & purificación , Kadsura/química , Sesquiterpenos/aislamiento & purificación , Antineoplásicos Fitogénicos/química , Antineoplásicos Fitogénicos/farmacología , Ensayos de Selección de Medicamentos Antitumorales , Células Hep G2 , Humanos , Estructura Molecular , Resonancia Magnética Nuclear Biomolecular , Tallos de la Planta/química , Sesquiterpenos/química , Sesquiterpenos/farmacologíaRESUMEN
One new triterpenoid (1) and 13 known compounds (2-14) were isolated from Schisandra pubescens stems. The structure of the new compound was established on the basis of 1D/2D NMR and HRESIMS spectroscopic analyses. The isolated compounds were evaluated for their hepatoprotective activities against D-GalN-induced cell injury in QSG7701 cells. Compounds 1, 13 and 14 at 10 µM showed hepatoprotective activities, with survival rates of 60.5, 50.4 and 48.9%, respectively.
Asunto(s)
Lignanos/farmacología , Sustancias Protectoras/química , Sustancias Protectoras/farmacología , Schisandra/química , Línea Celular , Evaluación Preclínica de Medicamentos/métodos , Hepatocitos/efectos de los fármacos , Humanos , Lignanos/química , Lignanos/aislamiento & purificación , Espectroscopía de Resonancia Magnética , Estructura Molecular , Tallos de la Planta/química , Triterpenos/química , Triterpenos/farmacologíaRESUMEN
One new compound, himalain A (1), together with 12 known compounds were isolated from Mirabilis himalaica. Their structures were determined by spectroscopic methods, including 2D NMR techniques, and the absolute configuration of the 1,2-diol moiety in 1 was defined through Riguera's method. All isolated compounds were tested for their cytotoxic and antibacterial activities.
Asunto(s)
Mirabilis/química , Éteres Fenílicos/aislamiento & purificación , Antibacterianos/farmacología , Antineoplásicos Fitogénicos/farmacología , Línea Celular Tumoral , Humanos , Éteres Fenílicos/química , Éteres Fenílicos/farmacologíaRESUMEN
A new isocoumarin, chamerilactone A(1) was isolated from the ethanol extract of Chamerion angustifolium with normal phase silica column chromatography, Sephadex LH-20, MCI CHP-20 and semi- preparative HPLC methods. Its structure and stereochemistry were elucidated by spectroscopic methods, including 2D-NMR and optical rotation techniques.
Asunto(s)
Isocumarinas/aislamiento & purificación , Onagraceae/química , Cromatografía Líquida de Alta Presión , Estructura MolecularRESUMEN
Phytochemical investigation on the seeds of Herpetospermum caudigerum afforded two new coumarin glycosides A and B (1 and 2), together with a known compound herpetolide A (3). Their structures were determined by spectroscopic methods, including 2D NMR techniques. Compound 3 exhibited cytotoxicity against HepG2 cells with IC50 value of 6.47 µg/ml. Compound 2 showed anti-hepatitis B virus activity with HBsAg secretion by 33.1% at 200 µg/ml.
Asunto(s)
Antivirales/aislamiento & purificación , Cumarinas/aislamiento & purificación , Cucurbitaceae/química , Glicósidos/aislamiento & purificación , Antivirales/química , Antivirales/farmacología , Cumarinas/química , Cumarinas/farmacología , Glicósidos/química , Glicósidos/farmacología , Células Hep G2 , Virus de la Hepatitis B/efectos de los fármacos , Humanos , Concentración 50 Inhibidora , Estructura Molecular , Semillas/químicaRESUMEN
A new dibenzocyclooctadiene lignan, renchangianin E (1) was isolated from the stems of Kadsura renchangiana. Its structure and stereochemistry were elucidated by spectroscopic methods, including 2D-NMR techniques.