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1.
Sci Rep ; 10(1): 17846, 2020 10 20.
Artículo en Inglés | MEDLINE | ID: mdl-33082472

RESUMEN

In order to understand the clinical manifestations and incidence of gastrointestinal symptoms of coronavirus disease (COVID-19) in children and discuss the importance of fecal nucleic acid testing.We retrospectively analyzed studies on gastrointestinal symptoms and fecal nucleic acid detection in pediatric COVID-19 patients from January 1, 2020 to August 10, 2020, including prospective clinical studies and case reports. The results of fecal nucleic acid detection were analyzed systematically. Stata12.0 software was used for meta-analysis.The results showed that the most common gastrointestinal symptoms in children with COVID-19 were vomiting and diarrhea, with a total incidence of 17.7% (95% Cl 13.9-21.5%). However, the prevalence of gastrointestinal symptoms in other countries (21.1%, 95% CI 16.5-25.7%) was higher compared to China (12.9%, 95% CI 8-17.7%). In Wuhan, the pooled prevalence was much higher (41.3%, 95% CI 3.2-79.4%) compared to areas outside Wuhan in China (7.1%, 95% CI 4.0-10.3%). The positive rate of fecal nucleic acid testing in COVID-19 children was relatively high at 85.8% (91/106). Additionally, 71.2% (52/73) were still positive for fecal nucleic acid after respiratory tract specimens turned negative. One and two weeks after the respiratory tract specimens turned nucleic acid-negative, 45.2% (33/73) and 34.2% (25/73) patients, respectively, remained fecal nucleic acid-positive. The longest interval between the respiratory tract specimens turning negative and fecal specimens turning negative exceeded 70 days. Conclusions and relevance: gastrointestinal symptoms in pediatric COVID-19 are relatively common. Attention should be paid to the detection of fecal nucleic acids in children. Fecal nucleic acid-negative status should be considered as one of the desegregation standards.


Asunto(s)
Betacoronavirus/genética , Infecciones por Coronavirus/diagnóstico , Heces/virología , Enfermedades Gastrointestinales/diagnóstico , Neumonía Viral/diagnóstico , Betacoronavirus/aislamiento & purificación , COVID-19 , Niño , Infecciones por Coronavirus/complicaciones , Infecciones por Coronavirus/epidemiología , Infecciones por Coronavirus/virología , Diarrea/complicaciones , Diarrea/diagnóstico , Diarrea/epidemiología , Enfermedades Gastrointestinales/complicaciones , Enfermedades Gastrointestinales/epidemiología , Humanos , Pandemias , Neumonía Viral/complicaciones , Neumonía Viral/epidemiología , Neumonía Viral/virología , Prevalencia , Pronóstico , ARN Viral/metabolismo , SARS-CoV-2
2.
Artículo en Chino | MEDLINE | ID: mdl-18038813

RESUMEN

Mice were divided into 3 groups: heavy infection group with 80 mice each was fed with 400 muscle larvae of Trichinella spiralis, light infection group with 60 mice each was fed by 200 larvae, and uninfected control (60 mice) . The content of Cu, Zn and Fe in the dorsal hair samples was measured in the week of 1, 3, 5, 7, 9, 11, 13 and 15 after infection. Results indicated that the content of Zn, Cu and Fe in the two experimental groups reduced considerably in comparison to the control (P < 0.05), especially for that of Zn and Cu. Lower content was found in the heavily infected mice than in those with light infection (P < 0.05).


Asunto(s)
Cabello/química , Oligoelementos/análisis , Trichinella spiralis/fisiología , Triquinelosis/metabolismo , Animales , Cobre/análisis , Cabello/parasitología , Interacciones Huésped-Parásitos , Hierro/análisis , Ratones , Ratones Endogámicos , Triquinelosis/parasitología , Zinc/análisis
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