Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 26
Filtrar
1.
Phlebology ; 28(7): 353-60, 2013 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-23202144

RESUMEN

OBJECTIVE: Chronic cerebrospinal venous insufficiency (CCSVI) was recently described in patients with multiple sclerosis (MS). The hypothesis of the vascular aetiology provides a new approach in the investigation and treatment of MS. METHODS: Our open-label study included 94 MS patients who fulfilled ultrasound sonographic criteria required for CCSVI. The internal jugular and/or azygous veins by a catheter venography were dilated. RESULTS: In 34.8% of the patients unilateral, in 65.2% bilateral venous abnormalities and in 2.1% no luminal obstructions were demonstrated. The patient group with the higher disability score had a significantly higher number of venous lesions (P < 0.005). Significant improvement of clinical disability in relapsing-remitting patients was (P < 0.001) achieved. In our study no stents were used. Re-stenosis occurred in 21.7% of the patients. CONCLUSION: The number of venous narrowings is higher in more disabled patients. A significant improvement in clinical disability in the relapsing-remitting group was observed.


Asunto(s)
Angioplastia de Balón , Esclerosis Múltiple , Insuficiencia Venosa , Constricción Patológica , Femenino , Humanos , Masculino , Esclerosis Múltiple/complicaciones , Esclerosis Múltiple/diagnóstico por imagen , Esclerosis Múltiple/terapia , Estudios Prospectivos , Ultrasonografía , Insuficiencia Venosa/diagnóstico por imagen , Insuficiencia Venosa/etiología , Insuficiencia Venosa/terapia
2.
Eur J Neurol ; 14(5): 505-9, 2007 May.
Artículo en Inglés | MEDLINE | ID: mdl-17437608

RESUMEN

The aim of this study was to describe the present involvement of neurologists in dementia management in European countries. Data were obtained from a questionnaire that members of The European Federation of Neurological Societies Scientific Panel on Dementia responded to. Information was obtained from 25 countries in Europe. A progressive decrease in the teaching activity from medical school to board-certified neurologists was reported. Teaching of medical students in dementia is obligatory in most countries, whereas there is no formal obligatory education in dementia after graduation from medical school. Further, in only half of the countries that responded to the questionnaire, obligatory courses in dementia are part of the training in neurology. Except for one country, the post-graduate training programs of board-certified neurologists do not include dementia as an obligatory topic. In only 10 of 25 countries, guidelines for neurologists on dementia evaluation have been published in local language. It is recommended to include obligatory teaching and training in dementia in the catalogue of minimum requirements for specialist training in neurology and this teaching should also be part of the ongoing update of certified neurologists.


Asunto(s)
Centros Médicos Académicos/tendencias , Demencia/diagnóstico , Demencia/terapia , Educación Médica Continua/tendencias , Educación de Postgrado en Medicina/tendencias , Neurología/educación , Centros Médicos Académicos/normas , Centros Médicos Académicos/estadística & datos numéricos , Educación Médica Continua/normas , Educación Médica Continua/estadística & datos numéricos , Educación de Postgrado en Medicina/normas , Educación de Postgrado en Medicina/estadística & datos numéricos , Europa (Continente) , Humanos , Comunicación Interdisciplinaria , Internado y Residencia/normas , Internado y Residencia/estadística & datos numéricos , Internado y Residencia/tendencias , Grupo de Atención al Paciente , Encuestas y Cuestionarios
3.
Electromyogr Clin Neurophysiol ; 40(3): 131-4, 2000.
Artículo en Inglés | MEDLINE | ID: mdl-10812534

RESUMEN

The psychophysically assessed thermal specific, thermal pain and vibration sensitivities were correlated to somatosensory evoked potentials in eighteen patients with definite multiple sclerosis. In the psychophysical tests, modality specific stimuli were used. Somatosensory potentials were electrically evoked. The abnormalities of both the temperature and the vibration sensitivity were to same extent related to the somatosensory evoked potentials. Dorsal columns-medial lemnisc and anterolateral-spinothalamic demyelinating lesions were presumed. The psychophysical tests supplement the clinical, laboratory, neuroradiologic and electrophysiological tests. These should be included in the battery of diagnostic tests in multiple sclerosis.


Asunto(s)
Potenciales Evocados Somatosensoriales/fisiología , Esclerosis Múltiple/diagnóstico , Umbral Sensorial/fisiología , Sensación Térmica/fisiología , Vibración , Adolescente , Adulto , Vías Aferentes/fisiopatología , Mapeo Encefálico , Femenino , Humanos , Masculino , Persona de Mediana Edad , Esclerosis Múltiple/fisiopatología , Umbral del Dolor/fisiología , Psicofísica , Piel/inervación
4.
Electroencephalogr Clin Neurophysiol ; 109(3): 274-80, 1998 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-9741795

RESUMEN

OBJECTIVES: Small and large, somatic and autonomic nerve fibre functions were neurophysiologically evaluated in 33 asymptomatic neurologically free type I diabetic children and 69 age-matched healthy controls. METHODS: The evaluation of large and small somatic nerve fibre function was performed by conventional nerve conduction studies, thermal specific and thermal pain sensitivity tests, as well as autonomic nerve fibre functions by sympathetic skin response and R-R interval variation assessment. RESULTS: A significant difference was established between the healthy and the diabetic group. Neurophysiologically determined subclinical neuropathy was found in 87% of type I diabetic children. The majority of abnormal recordings were found on the lower limbs. The dysfunction of the somatic motor large nerve fibre type in the lower limbs was altered in 57% of patients, somatic sensory large in 39%, somatic sensory small in 45%, and sympathetic in 45%. The leading abnormal measure was a delayed sympathetic skin response on the foot (42% of diabetic children) followed by a reduced amplitude of sural nerve action potential (36%). The whole spectrum of recordings showed scattered involvement of nerve functions. There was no selective susceptibility of nerve fibre types exposed to a noxious factor. CONCLUSION: A complex neurophysiological assessment, including standard nerve conduction studies as well as psychophysical examination and autonomic nerve function tests, evaluating the function of small and large nerve fibres, is recommended for evaluating the subclinical neuropathy in asymptomatic type I diabetic children.


Asunto(s)
Diabetes Mellitus Tipo 1/fisiopatología , Neuropatías Diabéticas/diagnóstico , Neuropatías Diabéticas/fisiopatología , Examen Neurológico , Adolescente , Niño , Femenino , Frecuencia Cardíaca/fisiología , Calor/efectos adversos , Humanos , Masculino , Neuronas Motoras/fisiología , Fibras Nerviosas/fisiología , Conducción Nerviosa/fisiología , Neuronas Aferentes/fisiología , Umbral del Dolor/fisiología , Piel/inervación , Piel/fisiopatología , Sistema Nervioso Simpático/fisiopatología
8.
J Neurol ; 244(6): 383-7, 1997 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-9249624

RESUMEN

We report three female patients, 43, 47, and 50 years old, with a rare asymmetric form of clinically pure sensory neuropathy associated with primary Sjögren's syndrome. In all three patients glandular involvement was accompanied by peripheral nerve disease. Sensory conduction studies showed completely normal results in two of three patients. Yet assessment of thermal-specific thresholds and thermal pain thresholds, combined with autonomic function tests (sympathetic skin response and R-R interval variation) supported the clinical suspicion of peripheral nerve disorder. Sjögren's syndrome must be considered in asymmetric sensory neuropathies of unknown cause.


Asunto(s)
Enfermedades del Sistema Nervioso Autónomo/patología , Conducción Nerviosa/fisiología , Neuronas Aferentes/patología , Síndrome de Sjögren/patología , Nervio Trigémino/patología , Edad de Inicio , Regulación de la Temperatura Corporal/fisiología , Femenino , Lateralidad Funcional/fisiología , Humanos , Persona de Mediana Edad , Síndrome de Sjögren/complicaciones , Termómetros
9.
Nervenarzt ; 68(6): 509-14, 1997 Jun.
Artículo en Alemán | MEDLINE | ID: mdl-9312685

RESUMEN

Quantitative assessment of thermal and pain sensitivity (Marstock method on a SOMEDIC Thermotest, Somedic AB Stockholm, Schweden) was made and the function of autonomic nervous system (sympathetic skin response and R-R interval variation) indicating the function of small nerve fibres (A-delta and C) was determined in 44 patients with symptoms of the presumed sensory neuropathy. The function of the large nerve fibres was evaluated by the classic nerve conduction study. The methods of small nerve fibres evaluation exhibited greater sensitivity as the classic nerve conduction study. The dysfunction of small nerve fibre function was morphologically proved by sural nerve biopsy.


Asunto(s)
Fibras Nerviosas Mielínicas/fisiología , Fibras Nerviosas/fisiología , Conducción Nerviosa/fisiología , Umbral del Dolor/fisiología , Parestesia/fisiopatología , Sensación Térmica/fisiología , Adulto , Anciano , Anciano de 80 o más Años , Sistema Nervioso Autónomo/patología , Sistema Nervioso Autónomo/fisiopatología , Axones/patología , Electrodiagnóstico , Femenino , Frecuencia Cardíaca/fisiología , Humanos , Masculino , Persona de Mediana Edad , Fibras Nerviosas/patología , Fibras Nerviosas Mielínicas/patología , Parestesia/etiología , Parestesia/patología , Nervios Periféricos/patología , Nervios Periféricos/fisiopatología , Células de Schwann/patología
10.
Electromyogr Clin Neurophysiol ; 36(4): 231-5, 1996 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-8803495

RESUMEN

Sympathetic skin response (SSR) was recorded in 23 patients with idiopathic Parkinson's disease (IPD) using mechanical as well as electrical stimuli. Significant delay of SSR latencies and decrease in amplitude of SSR compared to healthy volunteers were found (p < 0.05). Furthermore the clinical parameters of the autonomic impairment correlated well with the Webster score. Central mechanisms might be responsible for these findings and the role of central sympathetic pathway damage in parkinsonian patients is discussed.


Asunto(s)
Enfermedad de Parkinson/fisiopatología , Piel/inervación , Sistema Nervioso Simpático/fisiopatología , Adulto , Anciano , Electrofisiología , Femenino , Humanos , Masculino , Persona de Mediana Edad
12.
Pflugers Arch ; 431(6 Suppl 2): R305-6, 1996.
Artículo en Inglés | MEDLINE | ID: mdl-8739386

RESUMEN

In healthy volunteers thermal specific, thermal pain and vibration thresholds were assessed and correlated to each other and to sympathetic nervous system parameters. Additionally, different factors such as temperature, diazepam and ischemia affecting perception thresholds were evaluated. The thresholds assessed did not correlate significantly to each other and to sympathetic skin response latency or amplitude. Diazepam influenced the thermal specific, thermal pain and vibration thresholds assessed. The preingestion and postingestion (after 30, 60 and 90 minutes) thresholds did not differ significantly, meanwhile the scatter of thermal and vibration thresholds increased obviously. The skin temperature within the range of naturally occurring values of control subjects in a state of "thermal comfort" affected neither the warm-cold difference limen nor the heat and cold pain thresholds. Considerable temperature changes (the warming for 5 degrees C and cooling for 10 degrees C) influenced the vibration thresholds measured. Warming increased and cooling decreased the values recorded. Tourniquet-induced ischemia influenced only the vibration disappearance thresholds. Vibration perception and vibration thresholds varied but differences were not significant.


Asunto(s)
Diazepam/farmacología , Moduladores del GABA/farmacología , Umbral Sensorial/fisiología , Sistema Nervioso Simpático/fisiología , Umbral Auditivo/efectos de los fármacos , Umbral Auditivo/fisiología , Humanos , Isquemia/fisiopatología , Dimensión del Dolor/efectos de los fármacos , Umbral del Dolor/efectos de los fármacos , Umbral del Dolor/fisiología , Umbral Sensorial/efectos de los fármacos , Piel/inervación , Temperatura , Vibración
13.
J Neurol Sci ; 134(1-2): 136-42, 1995 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-8747856

RESUMEN

Vibration perception was quantitatively examined in 92 healthy volunteers (46 females, 36 males, aged 10-71 years). Vibration perception thresholds, vibration disappearance thresholds and vibration thresholds were assessed at the second metacarpal bone, styloid process of ulna, lateral epicondyle of humerus, first phalanx of the big toe, first metatarsal bone, medial malleolus and proximal part of the tibia bilaterally. Vibration sensitivity was found to be age-dependent. Under the age of 60, the correlation was linear. Vibration thresholds depended on body site but they were not related to sex or body side. Temperature and diazepam affect the perception of vibration considerably. Small interindividual variability was found in measurements repeated in 3 consecutive days, after 4 weeks and after a year.


Asunto(s)
Envejecimiento/psicología , Estatura/fisiología , Diazepam/farmacología , Percepción de Movimiento/fisiología , Caracteres Sexuales , Temperatura , Adolescente , Adulto , Anciano , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , Percepción de Movimiento/efectos de los fármacos , Reproducibilidad de los Resultados , Umbral Sensorial/efectos de los fármacos , Umbral Sensorial/fisiología , Vibración
15.
Neuropediatrics ; 26(5): 249-52, 1995 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-8552214

RESUMEN

This paper reports the results of botulinum toxin A treatment in 13 children with cerebral palsy. All patients except one exhibited dynamic deformities in one hand or foot and changes in muscle tone of corticospinal and extrapyramidal origin. The primary purpose of the treatment was to improve the impaired skilled movements which resulted from dystonic limb posture and were the most disabling symptoms in the group studied. The study showed that the botulinum toxin treatment produced a significant improvement in functional disability in terms of amelioration of skilled hand movements and foot posture (p < 0.01). The injections took effect a few days after dystonic muscle infiltration, and the mean duration of improvement was 3.1 months (2.0-4.0 months). Side effects were negligible and transient; transitory muscle weakness was the most frequent. Botulinum toxin A provides a safe and effective adjuvant treatment of dystonic skilled movements and gait disorders in children with cerebral palsy.


Asunto(s)
Antidiscinéticos/uso terapéutico , Toxinas Botulínicas/uso terapéutico , Parálisis Cerebral/terapia , Adolescente , Parálisis Cerebral/fisiopatología , Niño , Evaluación de la Discapacidad , Distonía/terapia , Femenino , Marcha , Humanos , Masculino , Movimiento
17.
Scand J Rheumatol ; 24(4): 257-9, 1995.
Artículo en Inglés | MEDLINE | ID: mdl-7481594

RESUMEN

An morphological confirmation of neurophysiologically assessed small nerve fibre dysfunction in a patient with Sjögren's syndrome was sought. Conventional motor and sensory nerve conduction studies were normal, while examination of the thermal specific and thermal pain sensitivity and an autonomic nervous system evaluation showed striking abnormalities. Sural nerve electron microscopy showed almost normally large nerve fibres and abnormalities in unmyelinated nerve fibres or Schwann cells, and verified morphologically the neurophysiologically supposed small nerve fibre involvement.


Asunto(s)
Fibras Nerviosas/fisiología , Enfermedades del Sistema Nervioso Periférico/patología , Enfermedades del Sistema Nervioso Periférico/fisiopatología , Síndrome de Sjögren/patología , Síndrome de Sjögren/fisiopatología , Femenino , Humanos , Persona de Mediana Edad , Conducción Nerviosa/fisiología , Dimensión del Dolor , Nervio Sural/patología , Nervio Sural/fisiopatología
18.
J Neurol Sci ; 127(2): 164-9, 1994 Dec 20.
Artículo en Inglés | MEDLINE | ID: mdl-7707075

RESUMEN

Values for thermal specific and thermal pain thresholds were determined in 150 healthy volunteers, 67 women and 83 men, aged from 10 to 73 years. Warm-cold difference limen, heat pain and cold pain thresholds were assessed at the face, thenar, medial surface of the upper- and forearm, lateral mammary, lateral umbilical, anterior thigh and lateral leg regions, and lateral aspect of the dorsum of the foot. Temperature and pain sensitivity were assessed by the Marstock method. Temperature sensitivity was found obviously age-dependent. The correlation is linear. Women showed greater sensitivity for small temperature changes, reflected as warm-cold difference limen, and for heat pain and cold pain. Great variation of thermal and pain sensitivity of different body parts was significant in all volunteers, irrespective of age and sex. Interindividual variation was also considerable. Small intraindividual variability was found in measurements repeated in 4 consecutive days and after 4 weeks. Body length did not influence thermal and pain perception thresholds. There were no differences found in thermal and pain sensitivity between the left and the right side of the body.


Asunto(s)
Dimensión del Dolor/métodos , Adolescente , Adulto , Anciano , Envejecimiento/fisiología , Niño , Frío , Femenino , Calor , Humanos , Individualidad , Masculino , Persona de Mediana Edad , Dimensión del Dolor/instrumentación , Umbral del Dolor/fisiología , Caracteres Sexuales , Fenómenos Fisiológicos de la Piel
19.
Clin Investig ; 72(11): 822-9, 1994 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-7894206

RESUMEN

Peripheral nervous system complications are rare in patients with primary Sjögren's syndrome. We investigated a group of six women aged 43-64 years who complained of pain and sensory symptoms. Conventional neurophysiological tests reflecting large nerve fiber function revealed normal motor conduction in all patients, whereas sensory nerve action potentials were absent in two. On the other hand, quantitative thermometry and autonomic nerve function tests indicating small nerve fiber function were more sensitive in the assessment of nerve dysfunction; these showed abnormalities in all cases. Vibrametry showed dysfunctions in four patients. The latter methods possess great sensitivity in discovering sensory disturbances. Neurophysiological assessment of the sensory and autonomic nervous system demonstrating sensory neuropathy contributes to early diagnosis of primary Sjögren's syndrome.


Asunto(s)
Enfermedades del Sistema Nervioso Periférico/fisiopatología , Síndrome de Sjögren/fisiopatología , Adulto , Anciano , Anciano de 80 o más Años , Estudios de Evaluación como Asunto , Femenino , Humanos , Persona de Mediana Edad , Dolor/fisiopatología , Enfermedades del Sistema Nervioso Periférico/etiología , Síndrome de Sjögren/complicaciones , Vibración
20.
Ann N Y Acad Sci ; 710: 76-87, 1994 Mar 09.
Artículo en Inglés | MEDLINE | ID: mdl-8154763

RESUMEN

Botulinum toxin therapy is safe and effective in the treatment of different movement disorders, especially focal dystonias. We reviewed botulinum toxin treatment of 97 patients: 36 had blepharospasm, 41 had torticollis, and 20 had diverse movement disorders. Patients with blepharospasm and torticollis improved markedly after botulinum toxin injections. The most common side effect in BS patients was ptosis (44.4%); in TC patients, it was dysphagia (29.3%). The mean duration of the improvement in both groups was 3.4 months. Very promising results were obtained also in the heterogeneous group including patients with other focal dystonias and cerebral palsy. On the basis of these results, we concluded that BTA injections must now be considered the mainstay of therapy for focal dystonias and other involuntary movement disorders.


Asunto(s)
Blefaroespasmo/tratamiento farmacológico , Toxinas Botulínicas/uso terapéutico , Trastornos del Movimiento/tratamiento farmacológico , Tortícolis/tratamiento farmacológico , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Blefaroespasmo/fisiopatología , Toxinas Botulínicas/efectos adversos , Niño , Femenino , Humanos , Masculino , Persona de Mediana Edad , Trastornos del Movimiento/fisiopatología , Tortícolis/fisiopatología
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA