RESUMEN
Sweet syndrome (SS), also known as acute febrile neutrophilic dermatosis is a rare cutaneous disorder characterized by specific clinical, biological and microscopic findings. Although the exact cause of SS is still unknown, it may be triggered by infections, malignancies and drugs but also occurring after vaccinations such as bacille calmette guerin vaccination and influenza vaccine. While the recently discovered SARS COV2 vaccines are almost safe, many cutaneous and extracutaneous minor adverse effects are reported. We herein describe the fourth case of Sweet Syndrome induced by SARS-COV2 vaccine.
Asunto(s)
COVID-19 , Vacunas contra la Influenza , Síndrome de Sweet , Vacunas contra la COVID-19/efectos adversos , Humanos , ARN Viral , SARS-CoV-2 , Síndrome de Sweet/diagnóstico , Síndrome de Sweet/etiologíaAsunto(s)
Melanoma/diagnóstico , Sarcoma de Células Claras/diagnóstico , Neoplasias de los Tejidos Blandos/diagnóstico , Adulto , Articulación del Tobillo , Resultado Fatal , Pie , Humanos , Imagen por Resonancia Magnética , Masculino , Melanoma/patología , Sarcoma de Células Claras/patología , Neoplasias de los Tejidos Blandos/patologíaRESUMEN
INTRODUCTION: Pseudoxanthoma elasticum (PXE) is an inherited metabolic disease with many systemic manifestations. We report 5 cases. OBSERVATIONS: The first patient presented cutaneous (yellowish grouped papules with reticulate pigmentation) and ocular manifestations (angioid streaks). The second patient is the sister of the first and presented the same clinical signs. The third is the mother of the two previous patients. The diagnosis of PXE was made on using a skin biopsy of healthy skin during family screening. The fourth patient presented yellow grouped papules with cutaneous hyper-elasticity and angioid streaks. The fifth patient presented essentially cardiovascular symptoms: arterial hypertension, total aortal dilation, arteriopathy and a cerebral vascular accident. DISCUSSION: Cutaneous manifestations are frequent (70 to 85%). Ocular signs are associated with the cutaneous signs in around 90% of PXE. The vascular lesions condition the vital prognosis. The gold standard of diagnosis is skin biopsy taken from damaged skin but it can also be positive even in normal skin (cases 3 and 5). Our series is characterised by the existence of unusual clinic manifestations of PXE: reticulated pigmentation and total aortal dilation. CONCLUSION: The PXE is a rare metabolic disease whose diagnosis is classically histopathological. Nowadays, molecular diagnosis is also possible.
Asunto(s)
Seudoxantoma Elástico/diagnóstico , Adulto , Biopsia , Enfermedades Cardiovasculares/diagnóstico , Enfermedades Cardiovasculares/genética , Enfermedades Cardiovasculares/patología , Aberraciones Cromosómicas , Diagnóstico Diferencial , Diagnóstico por Imagen , Femenino , Francia , Genes Dominantes , Humanos , Persona de Mediana Edad , Fenotipo , Pronóstico , Seudoxantoma Elástico/genética , Seudoxantoma Elástico/patología , Piel/patología , Enfermedades Cutáneas Genéticas/diagnóstico , Enfermedades Cutáneas Genéticas/genética , Enfermedades Cutáneas Genéticas/patologíaRESUMEN
Pityriasis Rotunda is a dermatosis well known in Japan and Black Africa. Its unusual in Europe and North Africa. Several authors consider that Pityriasis Rotunda is an acquired ichtyose and that it represents a real paraneoplastic syndrome. We report the case of Tunisian men suffering from a Pityriasis Rotunda associated to a dilatation of branch.
