RESUMEN
The presence of laryngeal disease affects vocal fold(s) dynamics and thus causes changes in pitch, loudness, and other characteristics of the human voice. Many frameworks based on the acoustic analysis of speech signals have been created in recent years; however, they are evaluated on just one or two corpora and are not independent to voice illnesses and human bias. In this article, a unified wavelet-based paradigm for evaluating voice diseases is presented. This approach is independent of voice diseases, human bias, or dialect. The vocal folds' dynamics are impacted by the voice disorder, and this further modifies the sound source. Therefore, inverse filtering is used to capture the modified voice source. Furthermore, the fundamental frequency independent statistical and energy metrics are derived from each spectral sub-band to characterize the retrieved voice source. Speech recordings of the sustained vowel /a/ were collected from four different datasets in German, Spanish, English, and Arabic to run the several intra and inter-dataset experiments. The classifiers' achieved performance indicators show that energy and statistical features uncover vital information on a variety of clinical voices, and therefore the suggested approach can be used as a complementary means for the automatic medical assessment of voice diseases.
RESUMEN
Harlequin ichthyosis (HI) is a rare and severe form of ichthyosis and is characterized by thickened, hard, armor-like plates of skin that cover the entire body. This disease is caused by mutations in the adenosine triphosphate-binding cassette transporter protein A12 gene, and the pattern of inheritance is autosomal recessive. Prenatal sonographic diagnosis of HI has not been frequently reported. Here, we report a case of HI detected at 28 weeks of gestation and discuss with the sonographic findings and a brief review of literature. The diagnosis was reached mainly based on 2-dimensional and 3-dimensional ultrasound findings. Three-dimensional ultrasound applications help recognize facial morphology, and thus, greatly contributes to prenatal diagnoses.
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