RESUMEN
During COVID19 and other viral pandemics, rapid generation of host and pathogen genomic data is critical to tracking infection and informing therapies. There is an urgent need for efficient approaches to this data generation at scale. We have developed a scalable, high throughput approach to generate high fidelity low pass whole genome and HLA sequencing, viral genomes, and representation of human transcriptome from single nasopharyngeal swabs of COVID19 patients.
RESUMEN
BACKGROUND: Large, compressive thyroid masses are usually removed as an elective procedure. Rarely is a patient's condition allowed to progress to severe respiratory distress before surgical intervention is recommended. When allowed to progress, management of the airway can be problematic. METHODS: A case report of a patient with a neglected thyroid lymphoma is presented. RESULTS: The natural progression of the disease, leading to impending airway collapse, necessitated emergency management of the airway. Due to supraglottic edema and a large neck mass, traditional methods of securing the airway were not feasible. Initiation of femoral-femoral cardiopulmonary bypass, under local anesthesia, ensured adequate oxygenation and allowed a controlled tracheotomy to be performed. CONCLUSIONS: The result obtained suggests that this approach provides a safe solution for airway control when intubation or a surgically created airway is either unsuccessful or too hazardous.
Asunto(s)
Obstrucción de las Vías Aéreas/etiología , Puente Cardiopulmonar , Linfoma/complicaciones , Linfoma/cirugía , Neoplasias de la Tiroides/complicaciones , Neoplasias de la Tiroides/cirugía , Anciano , Femenino , Humanos , TraqueotomíaRESUMEN
A case of papillary carcinoma of the thyroid occurring in association with systemic sarcoidosis is reported. Although benign thyroid disorders occurring in conjunction with sarcoidosis have previously been documented, a search of the literature found no report of thyroid carcinoma occurring in association with sarcoidosis. Diagnosis and therapeutic management prove difficult when thyroid carcinoma and sarcoidosis co-exist. Transbronchial biopsy of lung lesions is warranted in staging thyroid carcinoma in order to exclude the possibility of unknown co-existent disease. The management of cervical lymphadenopathy in thyroid carcinoma should not be altered because of the presence of sarcoidosis, and should include a neck dissection.
Asunto(s)
Adenocarcinoma Papilar/complicaciones , Enfermedades Pulmonares/complicaciones , Sarcoidosis/complicaciones , Neoplasias de la Tiroides/complicaciones , Adenocarcinoma Papilar/patología , Adulto , Biopsia , Diagnóstico Diferencial , Femenino , Humanos , Pulmón/patología , Enfermedades Pulmonares/patología , Ganglios Linfáticos/patología , Metástasis Linfática , Sarcoidosis/patología , Glándula Tiroides/patología , Neoplasias de la Tiroides/patologíaRESUMEN
Criteria for the definition and classification of retrosternal goiter are described. The management of retrosternal goiter, including the surgical approaches available, is discussed on the basis of clinical experience with 12 cases.
Asunto(s)
Bocio Subesternal/diagnóstico , Anciano , Diagnóstico Diferencial , Femenino , Bocio Subesternal/diagnóstico por imagen , Bocio Subesternal/patología , Bocio Subesternal/cirugía , Humanos , Masculino , Neoplasias del Mediastino/diagnóstico , Persona de Mediana Edad , RadiografíaRESUMEN
Three cases are reported of brachial plexus tumors that presented as a lump in the neck. Problems that arise when faced with such a diagnosis are discussed. A suggested protocol of management of these cases is described. The possibility of a brachial plexus tumor should be included in the differential diagnosis of a patient presenting with a mass in the neck.
