Evaluation of Pregnancy, Younger Age, and Old Age as Independent Risk Factors for Poor Hospitalization Outcomes in Influenza A (H1N1)pdm09 Virus a Decade After the Pandemic.

Introduction The influenza A (H1N1)pdm09 virus infection was first reported in Mexico in 2009 and quickly became the first flu pandemic of the 21st century. Statistics show that the prevalence of H1N1 infection was higher among young adults during the pandemic while the elderly were at more risk of death. However; many studies have shown a gradual change over the years, with attack rates increasing in older adults as compared to young adults. The other significant vulnerable group for this infection seems to be pregnant women. Over the years, many authors have found that pregnancy may not be a significant risk factor for increased hospitalization and poorer outcomes. This study aims to perform a comparative analysis and thereby assess pregnancy, younger age, and old age as independent risk factors for poor hospitalization outcomes. Materials and methods The hospital records of all patients with H1N1 infection admitted between January 1, 2018, to December 31, 2018, were screened. The patients included in the study were young adults (18-31 years), pregnant women, and the elderly (≥65 years). Comparative analysis was done between them. Nominal variables were compared using the chi-square test. Results A total of 379 patients were admitted to our hospital with H1N1 infection from January 1, 2018, to December 31, 2018. There were 75 elderly (19.7%), 224 (59%) middle-aged adults, 55 (14.5%) young adults, and 25 (6.5%) pregnant women. Fever (90%, 84%, and 96%) and cough with expectoration (72%, 67.3%, and 40%) were the most prevalent symptoms. The elderly reported more dyspnoea (28% vs. 5.5%, 4 %). Diabetes mellitus was found in 73.3 % of the elderly, 3.6% of the young adults, and 12% of pregnant women. Hypertension was present in 45% of the elderly, 1.8% of young adults, and 4% of pregnant women. Coronary artery disease was seen in 22.7% of the elderly and 1.8% of young adults. Chronic kidney disease (5.3%) and chronic obstructive pulmonary disease (13.3%) were seen only in the elderly group. Relative lymphopenia was prevalent in all groups and was more in pregnant women (76% vs. 61.8% and 41.8%) as compared to other groups. Serum creatinine was elevated in 38% of the elderly, 2% of young adults, and 0% of pregnant women. Abnormal chest radiograph was reported for 48% of the elderly, 30.9% of young adults, and 12% of pregnant women. Twenty-six point seven percent (26.7%) of the elderly needed more than a weeks' stay as compared to 7.3% of young adults and 20% of pregnant women. Thirty-two percent (32%) of the elderly required intensive care as compared to 1.5% of young adults and none of the pregnant women. More of the elderly (26.7%) required ventilator support than other groups (7.3% and 4%). About 25.3% of the elderly had a superinfection. Eight percent (8%) of the elderly died in the study while none died in the other groups. Conclusion Age representation and poor hospitalization outcomes due to H1N1 seem to have shifted from young adults to older age groups. The elderly are at more risk for a prolonged stay, intensive care, ventilator support, and death as compared to young adults and pregnant women. Pregnancy may not be associated with poor hospitalization outcomes for H1N1 as has been earlier thought.

Investigation on Effect of Material Hardness in High Speed CNC End Milling Process.

This research paper analyzes the effects of material properties on surface roughness, material removal rate, and tool wear on high speed CNC end milling process with various ferrous and nonferrous materials. The challenge of material specific decision on the process parameters of spindle speed, feed rate, depth of cut, coolant flow rate, cutting tool material, and type of coating for the cutting tool for required quality and quantity of production is addressed. Generally, decision made by the operator on floor is based on suggested values of the tool manufacturer or by trial and error method. This paper describes effect of various parameters on the surface roughness characteristics of the precision machining part. The prediction method suggested is based on various experimental analysis of parameters in different compositions of input conditions which would benefit the industry on standardization of high speed CNC end milling processes. The results show a basis for selection of parameters to get better results of surface roughness values as predicted by the case study results.

Protective effect of dietary squalene supplementation on mitochondrial function in liver of aged rats.

Mitochondria are an important intracellular source and target of reactive oxygen species. The life span of a species is thought to be determined, in part, by the rate of mitochondrial damage inflicted by oxygen free radicals during the course of normal cellular metabolism. In the present study, we have investigated the protective effect of squalene supplementation for 15 days and 30 days on energy status and antioxidant defense system in liver mitochondria of 18 young and 18 aged rats. The dietary supplementation of 2% squalene significantly minimized aging associated alterations in mitochondrial energy status by maintaining the activities of TCA cycle enzymes (isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase and malate dehydrogenase) and respiratory marker enzymes (NADH dehydrogenase and cytochrome-c-oxidase) at higher level in the liver mitochondria of aged rats compared with unsupplemented controls. It exerted an antioxidant effect by inhibiting mitochondrial lipid peroxidation (malondialdehyde) in liver of young and aged rats. Supplementation with squalene also maintained the mitochondrial antioxidant defense system at higher rate by increasing the level of reduced glutathione and the activities of glutathione-dependent antioxidant enzymes (glutathione peroxidase and glutathione-S-transferase) and antiperoxidative enzymes (superoxide dismutase and catalase) in the liver of young and aged rats. The results of this study provide evidence that dietary supplementation with squalene can improve liver mitochondrial function during aging and minimize the age-associated disorders in which reactive oxygen species are a major cause.

Air quality modelling of vehicular emissions under GIS environment, for Coimbatore Corporation (west zone).

Environment pollution is simply a consequence of the anthropogenic activities of mankind. Emissions from the motor vehicles have been shown to be the major contribution to air pollution in the urban environment. The major pollutants are SO2, No(x) and CO. Of these pollutants carbon monoxide is of utmost importance as the pollutant has serious toxicological effects and proves fatal on mankind. In this study, the concentration of Carbon-Monoxide (CO) along and near the major roads at Coimbatore west zone due to vehicular emission is predicted using the Air Quality Modelling Software Called CALINE4 model. Using MAPINFO GIS environment, thematic maps of the CO pollution at different receptor heights were prepared. Also, the concentration of CO for the year 2004 at 1.8 m height and 5 m height were predicted. In addition, to create awareness about the air quality, suggestions had been given to take suitable measures from engineering and environmental point of view.